Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Abstract

Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers. While the use of antibiotics and PPIs remains the primary treatment approach, there is a growing interest in alternative therapies, including botanical extracts, natural products, and traditional medicines. Recent research has also explored the potential of probiotics, phage therapy, and novel antibiotics, such as rifabutin and furazolidone, in the treatment of H. pylori infection. Recent studies have also explored the potential of artificial intelligence (AI) in the diagnosis and management of H. pylori infection. AI-assisted screening methods have identified novel botanical extracts and natural products with anti-H. pylori activity, providing new avenues for therapeutic development. Additionally, AI can improve diagnostic accuracy and treatment outcomes. Although these alternative approaches show promise, further research is needed to confirm their efficacy, safety, and optimal dosing. Novel therapies such as phage therapy and new antibiotics may provide an alternative to traditional treatments and help overcome antimicrobial resistance.

Harnessing Technology to Revolutionize Personalized Therapies for Metrorrhagia

“…Different healing traditions around the world have developed pharmacological treatments for regulating menstruation based on locally available medicinal plants. While the scientific basis for many traditional remedies is lacking, they represent an important cultural backdrop for understanding historical management of menstrual disorders [57][58][59][60][61]. In traditional Chinese medicine, metrorrhagia falls under the categories of "uterine bleeding" and "flooding and spotting. "…”

Transforming Screening, Risk Stratification, and Treatment Optimization in Chronic Liver Disease Through Data Science and translational Innovation

“…54 However, model interpretability, prospective validation in diverse patient populations, and assessment of clinical utility remain critical priorities before the widespread adoption of artificial intelligence tools for guiding the management of this condition in clinical practice. 55 Making the most of emerging technologies will require modernizing infrastructure, including through expanded data interoperability. Electronic health records and regional repositories need to become more dynamic to capitalize on growing sources of clinical data.…”

Molecular Pathways in Sepsis Pathogenesis: Recent Advances and Therapeutic Avenues

“…H. pylori infection has been associated with extra-digestive disorders including cardiovascular, hematological, metabolic, autoimmune, and other diseases. Recent evidence suggests H. pylori may also contribute to sepsis pathogenesis through direct and indirect effects on the host immune response [2]. It can occur in both community and healthcare settings, with hospital-acquired sepsis posing a particular challenge [3].…”