The effect of wavelength on the variability of the flash visual evoked potential P2: A potential biomarker for mild cognitive impairment and Alzheimer's dementia

Arruda, James E.; Steele, James; McInnis, Madison; Rainey, Vanessa R.; Wade, Aaron

doi:10.1016/j.ijpsycho.2021.02.011

Cited by 2 publications

(4 citation statements)

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“…36,37,[38][39][40] In fact, research conducted by our laboratory indicated, unlike Subramanian and colleagues 41 , that the use of a blue optical filter with a transmission peak at 493 nm (ie, the wavelength of blue light only served to decrease the amplitude of the FVEP-P2 latency [response]), making it more difficult to identify the P2 component. 27 Therefore, selectively recruiting either the medium-and/or long-wavelength cones through the use of a red optical filter, combined with a briefer, but brighter strobe presentation, might produce a more precise P2 response and reduce the natural variability often associated with the recording of the FVEP-P2 latency.…”

Section: Discussionmentioning

confidence: 99%

“…As noted previously, laboratory-specific differences in recording parameters, acquisition systems, presentation systems, and stimulus characteristics may affect the latencies and amplitudes obtained from individual clinics. 1,[25][26][27] To control for such effects, Odom et al 25,26 suggested that clinics construct laboratory-based norms to determine whether obtained latencies are within normal limits. Below we demonstrate, by way of example, the process by which an investigator may standardize laboratory-based latencies and compare them to the latencies published previously by other investigators by using FVEP-P2 Conversion Scores.…”

Section: Calculation Of Fvep-p2 Conversion Scores Using Laboratory-ba...mentioning

confidence: 99%

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Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

2022

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Amnestic mild cognitive impairment (aMCI), which is characterized by normal daily activity, but a significant decline in episodic memory, is now widely accepted as a risk factor for the development of Alzheimer's dementia (AD). Research suggests that many of the same neuropathological changes associated with AD also occur in patients diagnosed with aMCI. A recent review of the literature revealed that the latency of the flash visual-evoked potential-P2 (FVEP-P2) may possess pathognomonic information that may assist in the early detection of aMCI. While standards exist for the recording of FVEP-P2, individual clinics often use recording parameters that may differ, resulting in latencies that may not generalize beyond the clinic that produced them. The present article illustrates the process by which the FVEP-P2 latency can be standardized across clinics using FVEP-P2 Conversion Scores. We then demonstrate the diagnostic accuracy of the newly developed scores. Method: In the present investigation, we used the previously unpublished data containing the FVEP-P2 latencies of 45 AD and 60 controls. Result: We were able to demonstrate the process by which individual clinics may first standardize FVEP-P2 latencies and then examine patient performance using FVEP-P2 Conversion Scores, providing clinicians with a richer context from which to examine the patient performance. Conclusion: Consistent with the findings of previous research, the findings of the present investigation support the use of the FVEP-P2 Conversion Scores in the diagnosis of AD. Future directions, including the modification of recording parameters associated with the FVEP-P2, are also discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Calculation Of Fvep-p2 Conversion Scores Using Laboratory-ba...mentioning

confidence: 99%

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

2022

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“…21 It was postulated that this variable could express the reduction of cholinergic functioning in the associative visual areas, where the P2 is thought to be generated. 22,23 However, it did not enter clinical practice because of high inter-individual variability 6 and high intra-individual variability of the P2 latency measured with single 24 and paired flash stimulation. 25 The paired stimulation has been used to increase the accuracy of these tests 3 focusing on P2 latency recovery: a higher predictive accuracy than the single flash condition was detected for an ISI of 100 ms.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impaired Visual Inhibition in Amnestic Mild Cognitive Impairment

et al. 2022

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Objective.The pathophysiology of amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD) is still a matter of debate. Visual system might be precociously altered, especially for its cholinergic connections. We thus studied patients with aMCI compared to AD with paired-pulse flash-visual evoked potentials (paired-F-VEPs), a putative marker of cholinergic function. Methods. We enrolled 12 adult patients with aMCI and 12 with AD. 14 normal age- and sex-matched subjects acted as controls (HS). Stimuli were single flashes, with interspersed random flash pairs at critical interstimulus intervals (ISIs, 16.5 to 125 ms) with closed eyes. The “single” (unconditioned) F-VEP was split into a “main complex” (50 to 200 ms after the flash) and a “late response” (200 to 400 ms). As for paired stimulation, the “test” F-VEP emerged from electronic subtraction of the “single” F-VEP from the “paired”-F-VEP. Results. In the single F-VEP, P2 latency was prolonged in patients (aMCI and AD) compared to HS ( p < .05). As to the paired F-VEPs, in aMCI the “late response” normal inhibition was abolished at ISIs 50–62.5 ms ( p ≤ .016), compared to AD and controls. No changes were detected for the “main complex”. Conclusions. Paired-F-VEPs demonstrate a defective neural inhibition in the visual system of patients with aMCI at critical intervals. It may represent a compensatory mechanism against neuronal loss, the failure of which may be involved in AD development. Paired-F-VEPs may warrant inclusion in future preclinical/clinical studies, to evaluate its potential role in the pathophysiology and management of aMCI.

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The effect of wavelength on the variability of the flash visual evoked potential P2: A potential biomarker for mild cognitive impairment and Alzheimer's dementia

Cited by 2 publications

References 30 publications

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

Impaired Visual Inhibition in Amnestic Mild Cognitive Impairment

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