The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency: a randomized double-blind controlled clinical trial

Abstract

Dysmenorrhea is common among women of reproductive age. This study aim was to investigate the effect of vitamin D (vit D) supplementation in treatment of primary dysmenorrhea with vit D deficiency. A randomized double-blind placebo-controlled clinical trial was conducted on 60 women with primary dysmenorrhea and vit D deficiency referred to our clinic at Arash Women's Hospital from September 2013 to December 2014. Eligible women were randomly assigned into treatment and control groups (30 in each group). Individuals in the treatment group received 50 000 IU oral vit D and the control group received placebo weekly for eight weeks. After two months of treatment, there was a significant difference in serum vit D concentration between the two groups (p < 0.001). Pain severity decreased significantly in treatment group after eight weeks of treatment. There was a significant difference in pain intensity between the two groups after eight weeks of treatment and one month after the end of treatment (p < 0.001 for both). A weekly high dose (50 000 IU) oral vit D supplementation for eight weeks in patients with primary dysmenorrhea and vit D deficiency could improve pain intensity.

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies

“…Women with primary dysmenorrhea who use non-steroidal anti-inflammatory drugs are suggested to use natural antioxidants such as vitamin E, vitamin C, and β-carotenoids for the reduction of pain [7,53]. Single randomized controlled trials showed the effect of vitamin supplements on the reduction of menstrual pain reduction [63,66,67], but a Cochrane meta-analysis on the effect of dietary supplements for primary dysmenorrhea lacked high quality evidence to support the effectiveness and safety of any dietary supplement for dysmenorrhea. Therefore, more research with higher methodological qualities are required [24].…”

Assessment of the Possible Role of Vitamin D Defificiency with the Relevant Mechanisms in Gynecological Disorders

“…(2016) tarafından yapılan bir diğer randomize kontrollü klinik çalışmada PD'li hastalara 8 hafta süreyle (50,000 IU/hafta) vitamin D desteği uygulanmış ve plasebo kontrol grubuna kıyasla hasta grubunda vitamin D düzeyleri yüksek bulunmakla (p<0,001) birlikte uygulama sonunda ve hatta uygulamadan bir ay sonra bile ağrı şiddetle-rinin düştüğü (p<0,001) rapor edilmiştir. 9 Ayrıca, ülkemizde yakın dönemde yapılan bir araştırmada 18-25 yaş arası PD'li kadınların kontrole kıyasla serum vitamin D düzeylerinin belirgin düşük (p=0,001), ağrı şiddetinin değerlendirildiği görsel analog ölçeği (VAS) skorlarının ise yüksek (p=0,001) bulunduğu, VAS skorları ile vitamin D düzeyleri arasında da zıt yönlü istatistiksel açıdan anlamlı bir ilişki (r=-0,713, p=0,001) bulunduğu bildirilmiştir. 10 Mevcut veriler ışığında vitamin D'nin özellikle ağrı kontrolü başta olmak üzere çeşitli PD semptomları üzerinde önemli etkileri olabileceği düşünülmektedir.…”

Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

“…According to some studies, the severity of manifestations were significantly decreased if high-dose cholecalciferol was prescribed [17,18].…”

“…According to some studies, the role of vitamin D deficiency in the development of menstrual disorders in women was considered to be proven; therefore, in these disorders, high-dose vitamin D had to be administered [2]. However, according to other authors, the level of vitamin D (in combination with calcium) was of no clinical significance and a positive correlation with the function of the reproductive organs was not found [3].…”