Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

Abstract

In the literature review, 50 scientific sources surrounding the problem of vitamin D deficiency, 80% of which amounted to the issuance of the last 5 years, have been analyzed. Despite the impact of vitamin D deficiency on the health of children and adolescents has been studied for a long time, the information on the role of vitamin D in the formation of menstrual function in pubertal girls is scant and ambiguous. Among the hypotheses of menstrual dysfunction with vitamin D deficiency, neurohumoral regulation of the hypothalamic-pituitary-ovarian system is considered to be essential due to the localization of vitamin D receptors (VDR), unlike other vitamins, in the nuclei of various tissues and organs. However, in the last 10 years, data on the role of genetic polymorphism of the VDR gene in the pathogenesis of various manifestations of menstrual dysfunction have been accumulated. Some studies indicated a beneficial effect of cholecalciferol on such menstrual dysfunctions as oligomenorrhea and dysmenorrhea. Regarding numerous data on the role of vitamin D, both traditional and recently published, there is a strong correlation between vitamin D deficiency and other various factors, determining a wide range of polymorphic clinical manifestations where menstrual dysfunction is essential in girls at the age of puberty. ARTICLE HISTORY

Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea

“…The VDR polymorphism and the subsequent Vit. D deficiency [ 28 , 29 ] or defective action [ 30 , 31 ] was reported with different female reproductive disorders [ 32 – 34 ].…”

“…A literature review (containing retrieved data from 50 scientific sources) reported an association between Vit. D deficiency and different pubertal menstrual dysfunctions [ 32 ].…”

Vitamin D level and hormonal status association in adolescent girls with oligomenorrhea

“…Найчастіше описується статус ВD у пацієнток із синдромом полікістозних яєчників, ендометріозом, лейоміомою матки, а також його рівень пов'язують із результатом екстракорпорального запліднення [14][15][16][17]. Незважаючи на те що статус ВD у дітей і підлітків вивчається багатьма дослідниками, його вплив на формування менструальної функції та її порушення в періоді пубертату вивчений недостатньо, про що свідчать поодинокі роботи [18,19]. Разом із тим необхідні дослідження з вивчення рівня ВD для підтвердження його ролі у формуванні порушень менструальної функції, особливо в підлітковому віці.…”

Vitamins and endocrine disruptors: the exohormone system

“…Vitamin D receptors are present in many cells, with otherwise regulated functions and in these cases calcitriol has a side-regulator role [17,18]. The classification of "vitamin" D is faulty, as it is a hormone, with regular receptor in the steroid (nuclear) receptor superfamily in which used to be overlaps between the receptors, considering the hormones and binding specificity of receptors [19,20].…”