The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study

Alavi, Nazanin; Ebrahimi, Morteza; Akbari-Asbagh, Firoozeh

doi:10.18502/ijrm.v18i2.6501

Cited by 10 publications

(10 citation statements)

References 27 publications

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“…Others were from Spain 49 , Belgium 7 , Slovakia 50 , Egypt 51 , Bosnia and Herzegovina 52 , Australia 53 , Japan 54 , and Canada 55 . Moreover, 21 studies were cross-sectional in design 7 , 14 , 24 – 29 , 33 , 36 , 37 , 39 , 40 , 42 , 43 , 46 , 47 , 49 , 51 , 52 , 54 , 9 case–control 30 – 32 , 38 , 41 , 44 , 45 , 48 , 50 and 6 cohorts 12 , 15 , 34 , 35 , 53 , 55 . Seventeen studies mentioned the season of sample collection 7 , 14 , 15 , 27 , 32 – 35 , 37 , 38 , 40 – 42 , 52 – 55 .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, 21 studies were cross-sectional in design 7 , 14 , 24 – 29 , 33 , 36 , 37 , 39 , 40 , 42 , 43 , 46 , 47 , 49 , 51 , 52 , 54 , 9 case–control 30 – 32 , 38 , 41 , 44 , 45 , 48 , 50 and 6 cohorts 12 , 15 , 34 , 35 , 53 , 55 . Seventeen studies mentioned the season of sample collection 7 , 14 , 15 , 27 , 32 – 35 , 37 , 38 , 40 – 42 , 52 – 55 . Twenty-five studies selected serum vitamin D < 20 ng/ml as deficient, eight studies serum vitamin D < 10 ng/ml, and the others did not mention the cut-off values.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-five studies selected serum vitamin D < 20 ng/ml as deficient, eight studies serum vitamin D < 10 ng/ml, and the others did not mention the cut-off values. Based on the NOS, 23 studies were ranked as high quality 7 , 12 , 15 , 24 , 27 – 29 , 32 – 35 , 37 , 42 – 46 , 48 – 50 , 53 – 55 and 13 moderate 14 , 25 , 26 , 30 , 31 , 36 , 38 – 41 , 47 , 51 , 52 , respectively. Table 1 provides the primary information of enrolled studies and Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies 7 , 14 , 28 , 32 , 34 , 37 , 40 – 42 , 45 , 46 , 51 , 53 , 54 with 3406 subjects evaluated the correlation between AMH and 25(OH)D. There was no significant correlation between AMH and 25(OH)D (Fisher’s Z: − 0.03; 95% CI − 0.11 to 0.04; P = 0.355) with considerable heterogeneity (I 2 = 73.3%, P < 0.001) (Fig. 7 ).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Karimi

Arab

Rafiee

et al. 2021

Sci Rep

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It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Karimi

Arab

Rafiee

et al. 2021

Sci Rep

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“…The study of Nazanin Alavi et al, [6] aimed to investigate the impact of vitamin D on AMH serum concentrations and AFC. 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass index of 25.11 ± 4.41 kg/m2.…”

Section: Discussionmentioning

confidence: 99%

Relation between vit D level and low antral follicle count in infertile female below 35 years

berry

Mentawy

Din

et al. 2021

Benha Journal of Applied Sciences

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Background: In the recent years, vitamin D has become a topical subject and a focus of research not only in reproductive medicine but across many medical disciplines. In reproductive medicine, studies have identified an association between vitamin D status in women and ovarian reserve, Aim and objectives: the aim of the study was to detect the relationship between vit D and low antral follicle count in infertile females below 35 years old, Subjects and methods: This was a cross-sectional observational study that was conducted at the outpatient clinic of obstetrics and gynecology in Benha university hospital and Tokh central hospital, The study was carried out on 50 infertile patients below 35 years old with low AFC diagnosed first by ultrasonography then vit d level was done for those patients to detect the relation between vit d and low AFC, Results: Patients' ages ranged from 22 to 34 years with mean of 25.98 years and median was 25 years. Mean ± SD of AFC among participant women was 4.35 ± 1.41, ranged from 4 to 6 years and median was 4 . Mean ± SD of Vitamin D was 18.67 ± 14.58(ng/ml) ranged from 13.5 to 28.2 (ng/ml) and median was 19.1 (ng/ml). There is a non-significant correlation between vitamin D and (Age, AFC and BMI).Conclusion: After conducting this study we could not found a significant correlation between vit D level and low antral follicle count. Future studies are required to investigate further interaction between vit D level and infertility.

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Dietary and lifestyle‐related factors behind delayed conception in females

Rizvi,

Rabail,

Munir

et al. 2024

Food Science & Nutrition

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Delayed conceiving is a failure of a female to attain clinical pregnancy within a year without the use of contraception or any precautionary measure. The females of reproductive age (20–49 years) are the sufferers, that is, about 1.5 million or 10% of couples globally are facing this issue. Delayed conception can be caused by several reasons including diet, lifestyle, and genetic and clinical problems. Deficiencies or overconsumption of any nutrient may also cause delayed conception in females. Dietary deficits such as iron, iodine, zinc, folate, and vitamin D reduce the ovarian reserve. Heavy metals such as copper, manganese, lead, and cadmium also have an impact on fertility. Overconsumption of fast foods and nonhome‐made foods increases the likelihood of infertility by 2–3. Smoking, physical activity, age, polycystic ovary syndrome (PCOS), obesity, and depression have all been considered lifestyle and clinical factors. If women have a sedentary lifestyle, too much exercise or obesity both contribute to infertility. In clinical factors, type 1 diabetes, insulin resistance, and hypertension mainly cause infertility. Our focus in this review is on the studies probe that how these variables contributed to delayed conception and how it can be controlled to help combat infertility. Prevention from delayed conception involves consuming a healthy and balanced diet that contains essential nutrients engaging in physical activity and abstaining from smoking, PCOS, and medical issues.

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The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study

Cited by 10 publications

References 27 publications

A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Relation between vit D level and low antral follicle count in infertile female below 35 years

Dietary and lifestyle‐related factors behind delayed conception in females

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