The effect of vitamin D supplementation on insulin and glucose metabolism in overweight and obese individuals: systematic review with meta-analysis

Jamka, Małgorzata; Woźniewicz, Małgorzata; Jeszka, Jan; Mardas, Marcin; Bogdański, Paweł; Stelmach-Mardas, Marta

doi:10.1038/srep16142

Cited by 88 publications

(69 citation statements)

References 50 publications

(198 reference statements)

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“…In this study, we investigated the relationship between vitamin D and DPN at different ages. The results showed that vitamin D was only associated with DPN in the elderly patients but not in young and [18][19][20] but not to improve blood glucose 21 and endothelial function. 22 Schwann cells are peripheral glial cells that synthesize and secrete various growth factors, such as nerve growth factor (NGF), insulinlike growth factor (IGF), ciliary neurotrophic factor (CNTF), and neurotrophin-3 (NT-3), and these growth factors play an important role in nerve damage and repair.…”

Section: Discussionmentioning

confidence: 84%

“…Regarding the mechanism involved, vitamin D deficiency can affect glucose metabolism by impairing islet β‐cell function, reduce neurotrophic factors causing neurological dysfunction, and attenuate anti‐inflammatory effects leading to vascular endothelial dysfunction and supporting the development of atherosclerosis, thereby promoting the occurrence and development of DPN . However, studies on vitamin D supplementation for DPN have been shown to improve DPN neuropathic pain and affect DPN development by repairing and protecting nerves but not to improve blood glucose and endothelial function …”

Section: Discussionmentioning

confidence: 99%

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Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

Niu

Peng

et al. 2019

Diabetes Metabolism Res

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Background The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this relationship in different age groups. Methods In this cross‐sectional study, 1461 patients admitted to the Department of Endocrinology at Xinhua Hospital from June 2016 to September 2017 were divided into three age groups: a Youth group (24‐44 years, n = 127), a Middle‐age group (45‐64 years, n = 779), and an Elderly group (≥65 years, n = 555). Basic information and laboratory results were collected from medical records. Results Among the patients, 32.72% had DPN, with 12.59% in the Youth group, 33.63% in the Middle‐age group, and 36.04% in the Elderly group. For the total sample and the Elderly group, serum 25(OH)D concentrations in DPN patients were lower than in non‐DPN patients (P < .05). The results of multivariate logistic regression indicated a low vitamin D concentration to be a risk factor for DPN in the Elderly group (P < .05), but such relationship was not found in the Youth or Middle‐age groups. Moreover, according to ROC analysis, a serum 25(OH)D level < 34.87 nmol/L suggests the occurrence of DPN in elderly patients with type 2 diabetes (P < .001). Conclusions This study is the first to report that a low vitamin D level is associated with DPN in diabetic patients over 65 years of age and might be used as a predictor of DPN in this population. The interaction between vitamin D and age in the development of DPN and its underlying mechanisms need to be further explored.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

Niu

Peng

et al. 2019

Diabetes Metabolism Res

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“…Although without significance, our results showed a positive correlation between VD and HDL-c levels. Sriram et al [34] and Prodam et al [35] showed that VD levels are negatively correlated with total cholesterol, Contradicting recent studies that have shown that supplementation with VD may improve glycemia and lipid profile in children with deficiency of this vitamin [36] [37] [38], Jamka et al [39] and Jamka et al [40] performed meta-analysis that showed no correlation between VD and glucose and lipid levels.…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

Haber¹,

Quesada²,

Lopes³

et al. 2018

JDM

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The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are particularly significant in adolescents since it influences several aspects of growth, development, and puberty. During this phase of life, both girls and boys develop reproductive aspects, and secondary sexual characteristics and the adequate nutritional status appear to be the prerequisite for normal pubertal development. Due to the importance of VD in adolescents, the objective of this study was to investigate the association of the levels of this vitamin with glycemic, lipid, and anthropometric profile and sexual maturation stages of adolescents. Anthropometric (weight and height) and biochemical (fasting glycemia, total cholesterol, HDL-c, LDL-c, and triglycerides) data and VD levels were collected in 67 adolescents. 66% of the adolescents showed VD sufficiency, 28% insufficiency, and 6% showed the deficiency. There was a significant difference in VD levels between the stages of sexual maturation for boys and girls. Overweight patients had lower serum VD levels. The correlation analysis indicated a positive correlation between VD and fasting glycemia and HDL-c, but with no significant difference. A negative correlation was observed between VD and cholesterol, LDL-c and triglycerides, but also with no significant difference. Once VD is crucial for bone health, and as it seems it is necessary to the homeostasis of glycemia, lipids, and body weight, we suggest that more studies should be conducted to confirm the precise role of this vitamin in the promotion and maintenance of health in this population. How to cite this paper: Haber, J.

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“…Other contrasting meta-analysis of 15 trials did not find sufficient evidence to recommend vitamin D supplementation for improving glycemia or insulin resistance in obese patients with diabetes, normal fasting glucose levels, or impaired glucose tolerance [67].…”

Section: Diabetesmentioning

confidence: 96%

Vitamin D and Cardiovascular Diseases

Buchwald¹,

Sokol²

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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Vitamin D deficiency is highly prevalent worldwide and has been implicated in the pathogenesis and complications of cardiovascular disease (CVD). Defining this relationship has been challenging, and the clinical application of vitamin D screening and supplementation for CVD risk prevention and modification remain uncertain. The available evidence includes large observational studies and smaller randomized trials mostly evaluating surrogate endpoints and scarcely directed at CV outcomes as a primary endpoint. Methodological heterogeneity is present among most of these trials. Clarification of the clinical application of this relationship through ongoing large randomized trials should have important implications for public health.

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The effect of vitamin D supplementation on insulin and glucose metabolism in overweight and obese individuals: systematic review with meta-analysis

Cited by 88 publications

References 50 publications

Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

Vitamin D and Cardiovascular Diseases

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