The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats

Doğan, Muhammed Fatih; Kaya, Kürşat; Demirel, Hasan Hüseyin; Başeğmez, Mehmet; Şahi̇n, Yasemin; Çiftçi, Osman

doi:10.1080/08923973.2023.2181712

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, increased prooxidant system activity and deterioration of the antioxidant system (Table 3) result in oxidative stress. The development of many chronic diseases, including diabetes [30], cancer [31], antiviral agents [32], and various agingrelated and central nervous system (CNS) disorders [33], can result in high levels of reactive oxygen and nitrogen species production. In addition, reactive oxygen Table 1.…”

Section: The Role Of Selenium In Oxidative Stress Inflammation and Im...mentioning

confidence: 99%

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Başeğmez¹

2023

Selenium and Human Health

Self Cite

View full text Add to dashboard Cite

Selenium, whose name comes from the Greek word for “Selene,” has been a topic of interest as a micronutrient ever since it was described in 1817 as a by-product of sulfuric acid manufacturing. Selenium, the most important micronutrient for both humans and animals, must be consumed daily to support the body’s natural metabolism and homeostasis. The small intestine is responsible for the absorption of selenium in both its organic and inorganic forms. Selenium is then able to be widely distributed throughout the body’s diverse tissues, where it plays an important role in the regulation of the synthesis of selenoproteins. The synthesis of human selenoproteins involves the incorporation of a selenium-containing homolog of cysteine in each of the 25 selenium-containing proteins that make up this series. Many selenoproteins, including glutathione peroxidase (GPX), thioredoxin reductase (TrxR), and iodothyronine deiodinases (IDD), function as crucial cellular defenses against oxidative stress. Therefore, selenium is extremely important in boosting antioxidant defense. Recent studies have also shown that there is a close relationship between selenium and inflammation, and that selenium has regulatory effects on inflammation by affecting the expression of various cytokines. This chapter’s goal was to thoroughly review the research on how selenium is related to antioxidant and anti-inflammatory activity.

show abstract

Section: The Role Of Selenium In Oxidative Stress Inflammation and Im...mentioning

confidence: 99%

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Başeğmez¹

2023

Selenium and Human Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…When the oxidative-antioxidant balance function is disrupted as a result of oxidative stress, several pathogenic processes can occur in vascular system. Oxidative stress and the formation of reactive oxygen species (ROS) contribute to the progression of tissue injury by activating the inflammatory response via the release of proinflammatory cytokines and the accumulation of inflammatory cells in tissues [6]. Endothelial dysfunction is important in the development of vascular diseases, and selenium reduces endothelial damage and prevents disruption of endothelial-dependent relaxation [7].…”

Section: Introductionmentioning

confidence: 99%

Vascular System: Role of Selenium in Vascular Diseases

Doğan¹

2023

Selenium and Human Health

View full text Add to dashboard Cite

The trace element selenium is crucial for cellular defense against oxidative stress and inflammatory reactions. Balanced selenium levels are important for the vascular system, whereas dysregulation can damage vascular reactivity. Reports have also supported the strong relationship between oxidative stress and vascular inflammation, which are induced by either the overproduction of reactive oxygen species (ROS) or the lack of antioxidant defense proteins. The damage of vascular smooth muscle and endothelium layer are frequently linked to vascular disorders such as hypertension, hypercholesterolemia, and atherosclerosis. Vascular diseases can result in life-threatening serious cardiovascular complications, such as blood clots, heart attack, and stroke. Selenium levels are crucial for preventing vascular damage; however, either low or extremely high amounts of selenium intake may contribute to the pathophysiology of vascular disorders. Selenoproteins are proteins such as glutathione peroxidase containing selenium in the form of the 21st amino acid, selenocysteine. Selenoproteins have the capacity to protect vascular smooth muscle and endothelium by lowering harmful ROS, which allows them to regulate normal vascular functions including vasoreactivity. The current chapter’s goal was to carry out a thorough evaluation of the literature on the connection between selenium and vascular disorders.

show abstract

“…Oxidative stress and the formation of reactive oxygen species (ROS) cause lung injury by activating pro-inflammatory cytokines and accumulating immune cells in the tissue. [9,13] In clinical studies on favipiravir, no life-threatening side effects like diarrhea, nausea, vomiting, the elevation of liver enzymes, increased serum uric acid and tachycardia have been reported. [14] One other important side effect is a decrease in neutrophil count.…”

mentioning

confidence: 99%

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Erbaş,

Celep,

Tekiner

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

This study aimed to present new data on the side effects of favipiravir on healthy lung tissue and the respiratory system. In the study, two different durations (5 and 10 days) were preferred to determine the effect of favipiravir treatment due to clinical improvement rates of approximately 5 and 10 days during the use of favipiravir in COVID‐19 patients. In addition, after 10 days of favipiravir treatment, animals were kept for 5 days without any treatment to determine the regeneration of lung tissues. Favipiravir was administered to rats by oral gavage at a daily dose of 200 mg/kg for 5 and 10 days, as in previous studies. At the end of the experiment, the histopathological and biochemical effects of favipiravir in the lung tissue were investigated. The data obtained from the study showed that favipiravir increased oxidative stress parameters, expression of apoptotic markers, and pro‐inflammatory markers in lung tissue. Since malondialdehydes is an oxidant parameter, it increased in favipiravir‐administered groups; It was determined that the antioxidant parameters glutathione, superoxide dismutase, glutathione peroxidase, and catalase decreased. Other markers used in the analysis are Bcl‐2, Bax, NF‐κB, interleukin (IL)‐6, Muc1, iNOS, P2X7R, IL‐6 and caspase‐3. The levels of Bax, caspase‐3, NF‐κB, IL‐6, Muc1, and P2X7R were increased in the Fav‐treated groups compared with the control. However, the levels of Bcl‐2 decreased in the Fav‐treated groups. The present study proves that favipiravir, widely used today, causes side effects in lung tissue.

show abstract

The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats

Cited by 4 publications

References 37 publications

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Vascular System: Role of Selenium in Vascular Diseases

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Contact Info

Product

Resources

About