The effect of Vitamin C on melanin pigmentation – A systematic review

Sanadi, Rizwan M; Deshmukh, Revati

doi:10.4103/jomfp.jomfp_207_20

Cited by 45 publications

(46 citation statements)

References 36 publications

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“…The two adjacent enol hydroxyl groups on the 2nd and 3rd positions in the molecule are easily dissociated to release H + , so it has the property of acid, also known as L-ascorbic acid. Vitamin C has many physiological effects, including depigmentation of melanin pigmentation spots on the skin and gums [ 7 ], improved oxidative stress and immune regulation [ 8 ], and even improved bone health and tendons [ 9 ]. A small number of scholars have studied the relationship between vitamin C and periodontitis and found that low intake people are more prone to periodontitis.…”

Section: Introductionmentioning

confidence: 99%

The association between dietary vitamin C intake and periodontitis: result from the NHANES (2009–2014)

Song

Zhu

2022

BMC Oral Health

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Background The purpose of this study was to investigate whether periodontitis is associated with dietary vitamin C intake, using data from The National Health and Nutrition Examination Survey (NHANES) 2009–2014. Methods The study included 5145 adults (age ≥ 30 years) with periodontitis as a dichotomous variable and daily intake of vitamin C as a continuous variable. Multiple sets of covariates, such as age, sex, number of flossing, etc., were selected. Using EmpowerStats version 3.0, multivariate logistic regression analysis and hierarchical analysis were performed on the data, and curve fitting graphs were made. Results There were no statistically significant differences (P > 0.05) between the four dietary vitamin C intake groups (quartiles, Q1–Q4) and covariates (drinking alcohol and hypertension). The low VC intake group (Q1) was more prone to periodontitis than Q2, Q3, and Q4 (all OR < 1.00). A threshold nonlinear association was found between vitamin C (mg) log10 transformation and periodontitis in a generalized additive model (GAM) (P = 0.01). Conclusion The relationship between dietary vitamin C intake and the likelihood of periodontitis was non-linear. The smallest periodontitis index occurred when dietary vitamin C intake was 158.49 mg. Too little or too much vitamin C intake increases periodontitis.

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Section: Introductionmentioning

confidence: 99%

The association between dietary vitamin C intake and periodontitis: result from the NHANES (2009–2014)

Song

Zhu

2022

BMC Oral Health

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“…A variety of different modalities have been proposed for removing hyperpigmentation involving bur abrasion, surgical scraping, gingival autograft, cryotherapy, electrosurgery, and laser [ 6 ]. In addition, some studies suggest that ascorbic acid (vitamin C) could be used to treat gingival pigmentation [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Successful Esthetic Approach of Gingival Depigmentation Using Microneedling Technique and Ascorbic Acid (Vitamin C)

Mostafa

M.AlOtaibi²

2022

Case Reports in Dentistry

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A gingival depigmentation is a periodontal plastic procedure that is performed in order to remove melanocytic pigmentation. A variety of different modalities have been proposed for removing hyperpigmentation involving surgical scraping, gingival autograft, cryotherapy, electrosurgery, and lasers. However, the microneedling technique is a nonsurgical procedure that creates microholes to facilitate the penetration of topical medications across the connective tissues. Case Description. A healthy female patient aged 25 years with a pigmented gingiva seeking gingival depigmentation. On examination, a dark brown ribbon of hyperpigmentation was observed within the mandibular attached gingiva. The case was diagnosed as physiological moderate gingival pigmentation ( pigmentation index score = 3 ). The patient was interested in achieving aesthetic results with minimally invasive, nonexpensive procedures. Based on the patient’s concerns, the microneedling technique using vitamin C was suggested and consented. We used a dermapen device to microneedle the gingiva until bleeding pinpoints were observed; then, topical ascorbic acid was applied. After 3 days, our outcomes revealed an excellent aesthetic pink gingival appearance. Conclusions and Practical Implications. Compared to other minimally invasive techniques, our technique is less expensive and more risk-free. Our novel technique of using dermapen and topical ascorbic acid has shown promising results to our case which gives new perspectives for its application in gingival depigmentation.

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“…In this experiment, the vacuole that contained ZnAA was used to treat melanocytes for the melanin reduction test, and called ZnAA_Vac. ZnAA_Vac were isolated from S. cerevisiae , and 5% (wt/vol) vacuoles were exposed to melanocyte for 24 h. “Wild-type” vacuole was used to compare with the activity of ZnAA_Vac, while 2% ascorbic acid was the positive control, due to its depigmenting effect [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Melanin Treatment Effect of Vacuoles-Zinc Oxide Nanoparticles Combined with Ascorbic Acid

et al. 2022

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Currently, ascorbic acid (AA) is widely used as a skin whitening material, but, AA, an unstable hydrophilic molecule, cannot penetrate the skin easily, due to the hydrophobic character of the stratum corneum. Therefore, we conjugated AA with hydrated zinc oxide—an inorganic matrix with positive surface charge, to improve the stability of AA. The metal-conjugated-ascorbic acid (ZnAA) was then combined with yeast vacuole through the vacuolar membrane proteins that relate to metal transportation to create an enhanced vacuole that contained ZnAA. The characteristics of vacuole with ZnAA (ZnAA_Vac) were next examined by various tests that included X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT–IR), Field emission scanning electron microscopy (FE–SEM), and energy-dispersive X-ray (EDX) analysis. Furthermore, the ability of ZnAA_Vac to degrade melanin was confirmed in both melanoma cell line B16F10, and the artificial human skin MelanoDerm. The results showed that ZnAA_Vac possessed a higher depigmenting effect than the wild-type vacuole or ascorbic acid by reducing 75% of melanin color. Interestingly, ZnAA_Vac was found to be harmless, and did not cause any cytotoxicity to the cells. Overall, ZnAA_Vac is expected to provide a robust, harmless, and effective whitening agent for the skin.

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The effect of Vitamin C on melanin pigmentation – A systematic review

Cited by 45 publications

References 36 publications

The association between dietary vitamin C intake and periodontitis: result from the NHANES (2009–2014)

The association between dietary vitamin C intake and periodontitis: result from the NHANES (2009–2014)

A Successful Esthetic Approach of Gingival Depigmentation Using Microneedling Technique and Ascorbic Acid (Vitamin C)

Melanin Treatment Effect of Vacuoles-Zinc Oxide Nanoparticles Combined with Ascorbic Acid

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