The effect of vasopressin upon the vasculature of the isolated perfused rat kidney

Abstract

SUAMARYThe timed uptake of 13II-labelled human serum albumin was used as an index of regional perfusion in the isolated rat kidney.1. Arginine vasopressin in doses of 1, 5 and 10 ,uu./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the 5 Itu. dose.2. Ornithine-8-vasopressin in doses of 5 and 10 ,u./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the IO ,uu. dose.3. When the relative viscosity of the perfusate was increased to a value of 2'0 from the control value of 1.7, both papillary perfusion and total renal perfusion were reduced.4. Arginine vasopressin further reduced papillary flow in kidneys perfused with high viscosity artificial plasma.

Effect of arginine vasopressin on renal medullary blood flow. A videomicroscopic study in the rat.

“…Thurau and co-workers (4), who measured medullary blood inflow indirectly by a dye dilution curve, observed that it fell after AVP. A decrease in medullary flow has also been reported by several investigators using indirect techniques (18)(19)(20)(21). Conversely, either no change or an increase in medullary flow after AVP was found by Aukland (22) (9), several substantive improvements in the videomicroscopy technique were introduced in the present study, as described recently by Holliger and co-workers (7).…”

The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series

“…There are three possible explanations for vasopressin's diuretic effect. Firstly, the renal vasculature seems to be relatively resistant to the vasoconstrictor effects of vasopressin [21]. At low doses, there is some renal efferent arteriolar vasoconstriction, relatively sparing the afferent renal arterioles, which therefore increases renal perfusion pressure [22].…”

The effect of AVP‐V1 receptor stimulation on local GFR in the rat kidney

“…Many studies have been done to elucidate whether or not the antidiuretic effect of AVP is in part mediated by renal vascular effects. The results are conflicting, suggesting both an AVP mediated change in distribution of RBF either towards the superficial cortex (Cross et al. 1974) or towards the deep cortex or medulla (Kurtzman et al.…”