The effect of AVP‐V₁ receptor stimulation on local GFR in the rat kidney

Abstract

The change in distribution of GFR not only between OC and IC, but also between OC and MC suggests that the afferent/efferent arterioles and not the medullary vasa recta is the main site of resistance change. We conclude that acute i.v. infusion of V1 receptor agonist in high doses reduces GFR more in superficial than in deep cortex in both euvolemic and water diuretic rats and that this may be of some importance for water conservation, adding to the V2- receptor effect on water permeability of the collecting ducts.

Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy

“…On the other hand, administration of the selective V1a receptor antagonist (VRA) prevented the development of proteinuria and hypertension in the 5/6 nephrectomy rat model and proteinuria in nephrotic syndrome in the adriamycin rat model [ 43 , 44 ]. It seems that the difference in these observations may be caused by a different V1aR activity in the various layers of the kidney cortex [ 45 ]. In our study, there was a significant decrease in eGFR in the N5/6 group compared with the other groups, which was associated with a decrease in the level of the V1a receptor protein in the kidney cortex.…”

Effects of pH and medullary blood flow on oxygen transport and sodium reabsorption in the rat outer medulla

“…The OM-to-systemic hematocrit ratio has been estimated as ϳ 90 -95% (35). Based on a number of whole blood hematocrit measurements in rats (30,38,46,47), OM hematocrit is taken as 45%.…”

Excretion of Proteins by Rat Kidney during Various Types of Diuresis

“…Since excretion of a protein filtered in glomeruli depends on its reabsorption, which can be different for various proteins, we calculated the rate of protein excretion in relation to glomerular filtration. Such calculations are necessary, because administration of water increases the volume of extracellular fluid, which promotes the increase in the rate of glomerular filtration [11]. Injection of furosemide [13] and infusion of PEG-400 [3] elevated renal blood flow and the rate of glomerular filtration.…”