The Effect of Various Steroids in Intact Male Rats

Selye, Hans; Albert, S.

doi:10.1097/00000441-194212000-00008

Cited by 22 publications

(6 citation statements)

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“…Dihydrotestosterone had no effect on the thymus of intact mice, but did prevent thymic hyper¬ trophy after orchidectomy. Testosterone markedly involutes the thymus in intact males (Selye & Albert, 1942a). It may therefore be surmized that testosterone and DHT may act differently on the thymus of young and old rats.…”

Section: Discussionmentioning

confidence: 96%

Effects of various steroids on the thymus, spleen, ventral prostate and seminal vesicles in old orchidectomized rats

Fitzpatrick¹,

Greenstein²

1987

Journal of Endocrinology

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The effects of several steroids on the regenerating thymus in ageing male rats have been studied. Rats aged from 12 to 15 months were orchidectomized and 7 days later implanted s.c. with silicone elastomer tubing containing 25 mg testosterone, 5 alpha-dihydrotestosterone (DHT), oestradiol, progesterone or corticosterone. One group of rats received an empty implant. Thirty days later the rats were killed and the thymus, spleen, ventral prostate and seminal vesicles weighed and retained for histology. Whole blood was taken for total and differential white cell counts; plasma was prepared for radioimmunoassay of testosterone, oestradiol, progesterone and corticosterone. After orchidectomy only, a multilobular thymus was present, and histologically the tissue appeared healthy. In testosterone- and oestradiol-treated rats, thymus weight was reduced to about 50% of that in untreated animals. Histologically, much of the thymus taken at autopsy was fat and what remained was poorly organized and contained a much lower density of thymocytes. The total white cell count was significantly reduced in these animals, the effect appearing to be predominantly on lymphocytes. Although treatment with DHT also resulted in a lower mean thymus weight than that of orchidectomized animals, histologically the tissue appeared similar to that of the untreated castrated animals. In rats treated with DHT, the total white cell count was significantly higher than in testosterone-implanted rats. Both progesterone and corticosterone implants resulted in significantly smaller mean thymus weights, although these steroids were not as potent as testosterone or oestradiol.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 96%

Effects of various steroids on the thymus, spleen, ventral prostate and seminal vesicles in old orchidectomized rats

Fitzpatrick¹,

Greenstein²

1987

Journal of Endocrinology

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“…The influence of sex hormones on the size and cellular appear ance of the seminal vesicle is well established from a lot of previous investigations (1,2,3,4,5,6,7,8,9,10,11,12,13,14).…”

Section: Les Vésicules Séminales Du Rat En Culture Tissulairementioning

confidence: 92%

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Bengmark¹,

Hesselsjoe²

1964

Urol Int

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“…Early work had showa that the exogenous administration of androsterone, 5-androstenediol, testosterone and testosterone propionate resulted in thymic atrophy in intact or c~strated animals (13,14,15). Androsterone and testosterone propionate were found to be the .…”

Section: Chapter II Review Of the Literature Steroid Hormones And Lymmentioning

confidence: 99%

“…It has been known for several decades that steroid treatment will produce thymic invo~ution (13,14,15 The Balb/c males and females described in Tables V and VII Thymus weight also appeared to vary with time ~fter irradia~ion.…”

mentioning

confidence: 97%

Androgen-induced immunosuppression

Weyant¹

2000

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It is wel females are more immunocompetent than males as evidenced by higher humoral antibody titers, iowered· susceptibility to infection, ~d more efficient graft rejection.Furthermore, females also exhibit a much-higher inc~dence ot ~uto-immune disease. In order to amplify the sensitivity of the responding system, we then elected to study testosterone immunosuppression in a regenerating hemopoietic system which was recovering from the ablative effects of sublethal irradiation.It w~s observed, using ~rradiated mice, that orchidectomy resulted in striking immunoenhancement, where as testosterone treatment produced suppression of the antibody response to S~BC immunization.A possible mechanism for the testosterone effect consisting of a preferential differentiation of the regenerating stem cell population ~long the myeloid pathway was explored. Differential white blood cell counts indicated that testosterone administration can produce a reversal ot the granulocyte:lymphocyte ratio resulting in a marked granulocytosis ~ith acco~panying lymphopenia. Interestingly, in one experiment where testosterone had been observed to induce this reversal of the granulocyte:lymphocyte ratio at eight weeks following irradiation, by 12 week~ the blood picture had returned to normal. However, marked immunosuppression was still evldent in these animals. 3These data have suggested that the immunosuppression pro~uced by testosterone may be the result of a preferential differentiat~on of.the regenerating stem cell population along the myeloid pathway, with a concurrent suppression of lymphocyte production. Furthermore, evidence suggests that there may be a selective sensitivity of one immunocyte subpopulation to testosterone modulation of differentiation. ANDROGEN-INDUCED IHMUHOSUPPRESSIONby DEBRA ANN WEY~T

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The Effect of Various Steroids in Intact Male Rats

Cited by 22 publications

References 0 publications

Effects of various steroids on the thymus, spleen, ventral prostate and seminal vesicles in old orchidectomized rats

Effects of various steroids on the thymus, spleen, ventral prostate and seminal vesicles in old orchidectomized rats

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Androgen-induced immunosuppression

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