The Effect of Various Doses of Oestradiol 17-  on Glycogen Deposition in the Rat Uterus, Cervix and Vagina

Gregoire, A. T.; Ramsey, Haley E.; Adams, A. Elizabeth

doi:10.1530/jrf.0.0140231

Cited by 26 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On days 6, 7 and 8, therefore, some glycogenic factor(s) produce a significant increase in local production of glycogen in decidual sites and upper vaginal tissue. While the administration of progesterone to spayed rats does not affect glycogen synthesis (Grégoire, Ramsey & Adams, 1967;Bo & Atkinson, 1952), it is believed to stimulate the production of endometrial and decidual tissue laden with glycogen during pregnancy (Cecil et al 1962). Since in the hamster, unlike the rat and mouse, implantation can occur with progesterone alone (Prasad, Orsini & Meyer, 1960;Orsini & Meyer, 1962), the local increase in the decidual swelling may be progesteronedependent.…”

Section: Resultsmentioning

confidence: 99%

The Glycogen Content of the Early Pregnant Female Hamster Genital Tract, the Fertile Conceptus and Artificially-Induced Deciduomata

Gregoire¹,

Richardson²

1970

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

The quantitative changes in glycogen content of the hamster uterus, cervix, upper and lower vagina during the first 8 days of pregnancy were measured. The amount of glycogen in the conceptual sites on days 6, 7 and 8 was determined and compared with that of artificially induced deciduomata. The greatest concentration of glycogen was demonstrated in the tissue of the upper portion of the vagina. While no significant differences were found in the uterus, cervix and lower vagina during the time-interval investigated, significant increases in glycogen in upper vaginal tissue occurred on the 6th, 7th and 8th day of pregnancy.Uterine glycogen during the first 5 days, or the interdecidual sites on days 6, 7 and 8, did not differ significantly in their glycogen content. On day 6, when the conceptual site becomes discernible, the glycogen values were increased by 370 % over the uterine levels of day 5 followed by a 28-and 31-fold increase on days 7 and 8.The glycogen content of deciduomata induced non-mechanically (saline, oil, air) or by trauma (scratching) did not differ significantly from that of the conceptual sites of normal pregnancy.These findings demonstrate that on day 6 a glycogenic stimulus is evoked which results in local stimulation of glycogen production in the decidual sites and the upper vagina. Induction of deciduomata by different procedures results in quantitatively similar amounts of the polysaccharide. The glycogenic factor, therefore (a) stimulates localized glycogen synthesis and (b) can be evoked by either natural or artificial means.

show abstract

Section: Resultsmentioning

confidence: 99%

The Glycogen Content of the Early Pregnant Female Hamster Genital Tract, the Fertile Conceptus and Artificially-Induced Deciduomata

Gregoire¹,

Richardson²

1970

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…hypophyseal storage and release of growth hormone (GH) in rats. Thus, fasting increases adrenal gland glycogen (1) but decreases pituitary GH progressively (2-4); alloxan diabetes increases adrenal and hypophyseal polysaccharide levels (5,6), yet decreases pituitary GH content and plasma "growth factors" (7,8); conversely, both ether vapor and surgical…”

Section: Discussionmentioning

confidence: 99%

“…In the latter, a linear dose response relationship between glycogen synthesis and minute amounts of estrogen, 2.5 Xl0~5 ng, were demonstrated (4), while progesterone, cortisol, or desoxycorticosteroids were ineffective (5). Cervical and uterine glycogen deposition was maximum in the castrate rat given estradiol (25 /xg) intramuscularly for 3 days (6). In contrast to the rat (1) and mouse (7), whose uterine glycogen is increased during proestrus, the greatest preovulatory glycogen concentration in the hamster genital tract occurs in the cervical and upper vaginal tissue approximately 12 hr prior to ovulation without a concomitant increase in the uterine tissue (8).…”

mentioning

confidence: 99%

Glycogen and Water Responses to Estrogen in the Hamster Reproductive Tract

Gregoire

Richardson

1970

Endocrinology

Self Cite

View full text Add to dashboard Cite

“…In the rat, rabbit, mouse and sheep the synthesis of uterine glycogen is dependent upon oestrogen (Hall 1965;Bitman et al 1967;Gregoire et al 1967;Cecil and Bitman 1968). Endometrial glycogen synthase activity was greatest at day 8 in the present experiment& but the second peak in independent glycogen synthase activity at day 0 suggests both progesterone and oestrogen may be concerned with glycogen metabolism in the sheep endometrium.…”

Section: Discussionmentioning

confidence: 40%

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Murdoch¹,

O’Shea²

1978

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

The activity of several enzymes has been measured in the oviducal mucosa, endometrium, caruncles, cervical mucosa and vaginal mucosa as well as in uterine, cervical and oviducal rinsings of ewes at days 0 (oestrus), 1, 8 and 15 of the oestrous cycle.Acid phosphatase activity was maximal during the luteal phase in the oviduct, endometrium and cervix, but not in the vagina where the highest level was on day 1. Alkaline phosphatase activity showed a significant rise at mid-cycle in the endometrium and caruncles as did glucose-6-phosphate dehydrogenase activity in the endometrium.Glycogen (starch) synthase in the endometrium and cervical mucosa was greater at days 0 and 8 than at days 1 and 15. Vaginal and caruncular total glycogen (starch) synthase activity showed a significant rise at mid-cycle. Active and total glycogen phosphorylase activities were maximal on days 8 and 15 in the vagina. Glycogen concentration was greatest at days 8 and 15 in the cervix, while oviduct values were lower on day 1 than at oestrus or day 15.In the oviduct rinsings alkaline phosphatase activity was greatest at day 1, whereas in cervical rinsings the activities of acid and alkaline phosphatases were less at oestrus than at days 8 and 15. The glycogen phosphorylase and p-glucuronidase activities in uterine rinsings were greater at days 8 and 15 than at oestrus.

show abstract

The Effect of Various Doses of Oestradiol 17- on Glycogen Deposition in the Rat Uterus, Cervix and Vagina

Abstract: The glycogen metabolism of the mammalian female genital tract is briefly reviewed and discussed.

Cited by 26 publications

References 9 publications

The Glycogen Content of the Early Pregnant Female Hamster Genital Tract, the Fertile Conceptus and Artificially-Induced Deciduomata

The Glycogen Content of the Early Pregnant Female Hamster Genital Tract, the Fertile Conceptus and Artificially-Induced Deciduomata

Glycogen and Water Responses to Estrogen in the Hamster Reproductive Tract

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Contact Info

Product

Resources

About