The effect of ultrasound on the gastric mucosa and its secretion of acid

The field of MRI-guided high intensity focused ultrasound surgery (MRgFUS) is a rapidly evolving one with many potential applications in neurosurgery. This is the first of three articles on MRgFUS, this paper focuses on the historical development of the technology and it's potential applications to modern neurosurgery. The evolution of MRgFUS has occurred in parallel with modern neurological surgery and the two seemingly distinct disciplines share many of the same pioneering figures. Early studies on focused ultrasound treatment in the 1940's and 1950's demonstrated the ability to perform precise lesioning in the human brain, with a favorable risk-benefit profile. However, the need for a craniotomy, as well as lack of sophisticated imaging technology resulted in limited growth of HIFU for neurosurgery. More recently, technological advances, have permitted the combination of HIFU along with MRI guidance to provide an opportunity to effectively treat a variety of CNS disorders. Although challenges remain, HIFU-mediated neurosurgery may offer the ability to target and treat CNS conditions that were previously extremely difficult to perform. The remaining two articles in this series will focus on the physical principles of modern MRgFUS as well as current and future avenues for investigation.

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“…(17-19) Similar data was presented by other physician groups in disorders ranging from gastric ulcers to Meniere's disease. (28, 41) …”

Section: Early Medical Applications Of Ultrasound and The Identificatmentioning

confidence: 99%

High-Intensity Focused Ultrasound Surgery of the Brain

et al. 2009

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“…tissue to US. Few years later, Jerome Gersten described the US treatment of muscle disorders and rheumatoid arthritis [4] while other groups described the treatment of Meniere's disease and gastric ulcer [5,6]. Lynn and Putnam, in 1942, treated 37 animals with high-frequency and short-wavelength ultrasound waves.…”

Section: Introductionmentioning

confidence: 99%

Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors

et al. 2019

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Oncology and cerebrovascular disease constitute two of the most common diseases afflicting the central nervous system. Standard of treatment of these pathologies is based on multidisciplinary approaches encompassing combination of interventional procedures such as open and endovascular surgeries, drugs (chemotherapies, anti-coagulants, anti-platelet therapies, thrombolytics), and radiation therapies. In this context, therapeutic ultrasound could represent a novel diagnostic/therapeutic in the armamentarium of the surgeon to treat these diseases. Ultrasound relies on mechanical energy to induce numerous physical and biological effects. The application of this technology in neurology has been limited due to the challenges with penetrating the skull, thus limiting a prompt translation as has been seen in treating pathologies in other organs, such as breast and abdomen. Thanks to pivotal adjuncts such as multiconvergent transducers, magnetic resonance imaging (MRI) guidance, MRI thermometry, implantable transducers, and acoustic windows, focused ultrasound (FUS) is ready for prime-time applications in oncology and cerebrovascular neurology. In this review, we analyze the evolution of FUS from the beginning in 1950s to current state-of-the-art. We provide an overall picture of actual and future applications of FUS in oncology and cerebrovascular neurology reporting for each application the principal existing evidences.

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The effect of ultrasound on the gastric mucosa and its secretion of acid

Cited by 2 publications

References 8 publications

High-Intensity Focused Ultrasound Surgery of the Brain

High-Intensity Focused Ultrasound Surgery of the Brain

Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors

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