The effect of triclosan on the proliferation of peritoneal tissue explants

β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

“…Based on this fact, the antibacterial activity of MGC is mainly dependent on its surface hydrophilicity. In addition to MGC, TCS improved antibacterial activity because it has a broad antimicrobial spectrum including bacteriostatic property as low concentration and induce cell death by disrupting bacteria membrane at high concentration [ 7 , 35 ]. The hydrogel with almost 40% of TCS release for 5 hours was found to have improved antibacterial activity [ 24 ].…”

“…However, normal wound healing was observed in the incision + MGC-g-CD-ic-TCS sample. These results can be ascribed by the cocktail effect of MGC and TCS, because MGC and TCS can provide appropriate tissue junction and antibacterial/antifungal effect, respectively [ 7 , 35 , 38 ]. An animal study demonstrated that MGC-g-CD-ic-TCS accelerates re-epithelialization and wound remodeling in incision, compared with suture, cyanoacrylate, and MGC.…”

“…In addition, chitosan hydrogel applied in the wounds of mice, rats, and pigs accelerates collagen synthesis, re-epithelialization, and angiogenesis [ 40 , 41 , 42 ]. In addition, TCS is known to possess a broad spectrum of antibacterial properties because it can inhibit the synthesis of fatty acid required for the membrane and wall of bacteria at low concentration and disrupt the membrane of bacteria at high concentration [ 7 , 35 , 38 ]. The stage of wound healing is a complex process involving numerous cells and cytokines in the temporospatial relationship [ 43 ].…”

“…In particular, antibacterial agent-containing hydrogels are currently a main focus in biomedical research and applications such as a surgical-site infection, because infection is a critical issue for successful wound healing [ 5 , 6 ]. Among the available antibacterial agents, triclosan (TCS) is a commonly used drug because of its broad spectrum of antibacterial activity, and TCS is widely used from industry to medical fields [ 7 ]. In medical fields, a TCS-coated suture is being used clinically.…”