The Effect of Treating the Virus of Tobacco Mosaic With the Juices of Various Plants

Duggar, B. M.; Armstrong, J. K.

doi:10.2307/2394061

Cited by 81 publications

(37 citation statements)

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“…Viral RNA depurination is a matter that is worthy of attention. Duggar and Armstrong [33] have observed that a protein from P. americana possessed an antiviral activity, and inhibited transmission of tobacco mosaic virus (TMV) in plants; though, not until 1978 PAP was accepted as an inhibitor of protein synthesis [25]. While the mechanism of PAP antiviral activity is somewhat unclear, recent findings, produced by the Hudak and Tumer laboratories, show that this activity is not dependent exclusively on inactivation of ribosomes [34,35].…”

Section: Activities Attributed To Papmentioning

confidence: 99%

Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana

Aitbakieva¹,

Domashevskiy²

2016

Biochem Pharmacol (Los Angel)

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Section: Activities Attributed To Papmentioning

confidence: 99%

Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana

Aitbakieva¹,

Domashevskiy²

2016

Biochem Pharmacol (Los Angel)

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“…The relationship between the virus replication and the host cell is very intimate; this is the first problem in the progress and thus needs a very effective antiviral. The second problem is the late identification of viral diseases when the treatment is not highly effective [32]. Antiviral's main target is viral nucleic acid, there are two kinds of viral nucleic acids which are Deoxyribonucleic Acid [DNA], and Ribonucleic Acid [RNA], containing the code responsible for viral replication in host cell and the spread of the virus and viral proteins, but there is not enough information about the stage of penetration at the virus propagation [33].…”

Section: Mechanisms Of Antiviral Activitiesmentioning

confidence: 99%

“…Antiviral's main target is viral nucleic acid, there are two kinds of viral nucleic acids which are Deoxyribonucleic Acid [DNA], and Ribonucleic Acid [RNA], containing the code responsible for viral replication in host cell and the spread of the virus and viral proteins, but there is not enough information about the stage of penetration at the virus propagation [33]. A good antiviral agent must stop the multiplication in the infected cell should not have any toxic effect on normal cells [32]. Antiviral chemical agents can stop the spread of the virus, control the visible symptoms and induce nature resistance by the host [3].…”

Section: Mechanisms Of Antiviral Activitiesmentioning

confidence: 99%

“…Some of them have been approved ability to treat viral infections in animals and people [22,23]. In 1925 Duggar and Armstrong found the first plant inhibitors, they discovered that TMV replication was inhabited by the extracts from different plants [24]. During the following 25 years, a lot of progress was achieved in the discovery of virus inhibitors [25,26].…”

Section: Plant As a Source Of Virucidesmentioning

confidence: 99%

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Plants as Antiviral Agents

Waziri¹

2015

J Plant Pathol Microbiol

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Viruses are microorganisms that infect all kinds of living organisms including plants, and cause remarkable lose in crop production. Although pesticides showed that they can protect plants from pest infections, there are no effective substances that can be used as potent virucides. Therefore, there is a continuous demand to produce chemicals in order to stop and cure viral infections in plants. However, toxicity and carcinogenicity issues were always attributed to chemical pesticides. Screening of natural products shined in the dark to find new safe virucides. The philosophy of selecting those plants is oriented towards plants that can protect themselves from viral infections. Plants have been reported as virus inhibitors and are able to prevent infection of viruses by inducing systemic resistance in noninfested parts of the plants, such as Boerhaavia diffusa, Clerodendrum aculeatum. Other plants defend themselves against virus infections; these plants contain ribosome inactivating proteins [RIPs], such as Phytolacca Americana, Mirabilis jalapa, Dianthus caryophullus. The methods used for extraction, separation, identification of those antiviral compounds are documented and discussed in this review.

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“…Infection by plant viruses has been shown to be inhibited by many chemicals in the juices extracted from infected plants: crude extracts of Phytolacca decandra L. (6), Beta vulgaris L., Beta vulgaris L. var. cicla, Spinacia oleracea L. (8,10), Chenopodium album L. (3,22,23), Chenopodium amaranticolor Coste & Reyn.…”

mentioning

confidence: 99%

Aggregation of Tobacco Mosaic Virus by Sodium Chondroitin Sulfate

Sano¹,

Inoue²

1980

Microbiology and Immunology

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The precipitation of tobacco mosaic virus by sodium chondroitin sulfate in an aqueous solution was investigated kinetically by means of turbidimetry. The virus solution became turbid after the addition of chondroitin sulfate. A threshold concentration of chondroitin, 1.33 mg/ml, was required for virus precipitation, irrespective of the virus concentration. The precipitation resulted from a mutual spatial exclusion phenomenon, leading to the separation of the virus as a crystalline phase. The dimension of chondroitin sulfate calculated at the threshold concentration agreed well with that obtained by other methods. The initial slopes and the aggregation half-times of the virus aggregates depended on both chondroitin and virus concentrations and the former increased with the increase in concentration of each. Above the threshold concentration of chondroitin sulfate, tobacco mosaic virus aggregation was a rapid-aggregation process and ended within 100 sec.The substances which inhibit the processes of infection by viruses are related to their antiviral actions. These inhibitors are divided into two categories: one is inhibitors of infection and the other is inhibitors of virus multiplication (1). The inhibitors of infection are substances that, when inoculated onto leaves simultaneously with viruses, prevent infection from occurring. The inhibitors of virus multiplication are substances that, when applied to leaves already infected, retard the rate at which the infecting viruses multiply .Infection by plant viruses has been shown to be inhibited by many chemicals in the juices extracted from infected plants: crude extracts of

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The Effect of Treating the Virus of Tobacco Mosaic With the Juices of Various Plants

Cited by 81 publications

References 0 publications

Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana

Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana

Plants as Antiviral Agents

Aggregation of Tobacco Mosaic Virus by Sodium Chondroitin Sulfate

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