The effect of transcranial direct current stimulation on the cortical activation by motor task in the human brain: An fMRI study

Jang, Sung Ho; Ahn, Sang Ho; Byun, Woo Mok; Kim, Chung Sun; Lee, Mi Young; Kwon, Yong Hyun

doi:10.1016/j.neulet.2009.05.037

Cited by 87 publications

(56 citation statements)

References 33 publications

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“…Lang et al (2005), as in our study, showed that only cathodal tDCS had a lasting effect on movement-related activity and suggested that cathodal tDCS might be more effective at interfering with motor execution than anodal tDCS. With a longer tDCS stimulation protocol (20 minutes; more than three times longer than our current protocol), Jang et al (2009) have observed a small increase in brain activation under the anode after stimulation. Although the differences in stimulation intensities and duration cannot be entirely excluded as cause for the absence of an anodal effect, the asymmetry of transcallosal inhibition between dominant and nondominant hemisphere should be considered (Netz et al, 1995).…”

Section: Study Limitationsmentioning

confidence: 48%

Bilateral Transcranial Direct Current Stimulation Modulates Activation-Induced Regional Blood Flow Changes during Voluntary Movement

Paquette

Sidel

Radinska

et al. 2011

J Cereb Blood Flow Metab

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Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that induces changes in cortical excitability: anodal stimulation increases while cathodal stimulation reduces excitability. Imaging studies performed after unilateral stimulation have shown conflicting results regarding the effects of tDCS on surrogate markers of neuronal activity. The aim of this study was to directly measure these effects on activation-induced changes in regional cerebral blood flow (DrCBF) using positron emission tomography (PET) during bilateral tDCS. Nine healthy subjects underwent repeated rCBF measurements with 15 O-water and PET during a simple motor task while receiving tDCS or sham stimulation over the primary motor cortex (M1). Motor evoked potentials (MEPs) were also assessed before and after real and sham stimulation. During tDCS with active movement, DrCBF in M1 was significantly lower on the cathodal than the anodal side when compared with sham stimulation. This decrease in DrCBF was accompanied by a decrease in MEP amplitude on the cathodal side. No effect was observed on resting or activated rCBF relative to sham stimulation. We thus conclude that it is the interaction of cathodal tDCS with activation-induced DrCBF rather than the effect on resting or activated rCBF itself which constitutes the physiological imaging correlate of tDCS.

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Section: Study Limitationsmentioning

confidence: 48%

Bilateral Transcranial Direct Current Stimulation Modulates Activation-Induced Regional Blood Flow Changes during Voluntary Movement

Paquette

Sidel

Radinska

et al. 2011

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…On the other hand, increasing the intensity or duration of the stimulation might also result in different effects. Indeed, it was lately observed that the BOLD signal evoked by grasping hand movements in a consecutive paradigm was increased in the sensorimotor area after 20 min anodal tDCS when compared to baseline (Jang et al, 2009). The authors concluded that a longer application of tDCS and a simpler motor task might be better to detect changes in cortical activation than the more complex tasks used by Baudewig et al (2001).…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation over the primary motor cortex during fMRI

et al. 2011

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“…However, the majority of previous combined tDCS and functional neuroimaging studies have focused on motor cortex stimulation, also including motor activation paradigms. Most studies found fMRI signal changes close to the stimulation site and in distant regions (Kwon et al, 2008;Jang et al, 2009;Stagg et al, 2009). Lang et al (2005) used H 2 15 O PET and observed an increased regional cerebral blood flow (rCBF) in widespread cortical and subcortical areas that reached the magnitude of effects of finger movement on rCBF in motor areas and were stable for ϳ50 min.…”

Section: Effects Of Tdcs In Models and Imaging Studiesmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

518

363

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Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCSmediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

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The effect of transcranial direct current stimulation on the cortical activation by motor task in the human brain: An fMRI study

Cited by 87 publications

References 33 publications

Bilateral Transcranial Direct Current Stimulation Modulates Activation-Induced Regional Blood Flow Changes during Voluntary Movement

Bilateral Transcranial Direct Current Stimulation Modulates Activation-Induced Regional Blood Flow Changes during Voluntary Movement

Transcranial direct current stimulation over the primary motor cortex during fMRI

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

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