The effect of total lignans from Fructus Arctii on Streptozotocin-induced diabetic retinopathy in Wistar rats

Establishing a UHPLC-MS/MS method for evaluation of the influence of stir-frying on the pharmacokinetics of seven compounds in Arctii Fructus

“…Furthermore, the C max , AUC (0–24h) , and the area under the curve from 0 extrapolated to infinity (AUC (0–∞) ) of 4-CQA, ARC and 3,4-diCQA exhibited remarkable differences between RAF and SAF, thereby showcasing the dynamic nature of the absorption in the treatment process. 16 Similarly, the AUC (0–24h) of ARC were 1074.25 ± 416.8 and 1967.51 ± 599.5 ng mL −1 for the RAF and SAF samples, respectively. From the study, a discernible increase in exposure of plasma to ARC from the AF was apparent following processing.…”

Natural Biologics Accelerate Healing of Diabetic Foot Ulcers by Regulating Oxidative Stress

“…However, although there are many natural biologics targeting the polyol signaling pathway [160,161], there are few studies on the application of DFU, and more relevant studies are focused on diabetic retinopathy. For example, total lignans from Fructuse Arctii improve diabetic retinopathy by inhibiting aldose reductase [162]. Moreover, resveratrol (3,4 ′ ,5-trihydroxy-stilbene) [163] and zinc supplementation [164] can also target the polyol pathway to improve diabetic lens lesions.…”

Phytochemicals and Biological Activities of Burdock (Arctium lappa L.) Extracts: A Review

“…[70] In addition, total lignans in A. lappa extracts have been suggested as the compounds responsible for the preventive effect in diabetic retinopathy. [90] Furthermore, polysaccharides obtained from extracts of A. lappa regulated lipid metabolism in animal models for type 1 and 2 diabetes. [79,80] Different other properties have also been reported as effective in the treatment of several conditions including, acne, [130] anti-aging, [44,131] antiobesity, [89] skin whitening agent, [19] anti-constipation and intestinal flora regulation, [83] neuroprotective effect, [13,82] hepatoprotective, [7,78,86] anti-tuberculosis, [61] anti-ulcer, [24,56] and cachexia induced by cancer.…”

“…Arctigenin is the main active metabolite responsible for this hypoglycemic effect since it can be converted into arctigenic acid (a compound able to restore early insulin secretion) in vivo [70] . In addition, total lignans in A. lappa extracts have been suggested as the compounds responsible for the preventive effect in diabetic retinopathy [90] . Furthermore, polysaccharides obtained from extracts of A. lappa regulated lipid metabolism in animal models for type 1 and 2 diabetes [79,80] .…”