The effect of TiO2 nanopowder coating on in vitro bioactivity of porous TiO2 scaffolds

Loča, Dagnija; Narkevica, Inga; Ozoliņš, Jurijs

doi:10.1016/j.matlet.2015.07.017

Cited by 14 publications

(12 citation statements)

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“…Scaffolds for TE must fulfill numerous requirements, including being biocompatible in bulk and degraded form, exhibiting suitable interconnected pore structure with pore size in the range 200‐400 μm (for bone TE) as well as sufficient mechanical properties and structural integrity . TiO 2 is one of the important bioceramics being considered to develop scaffolds for bone TE . These scaffolds show good mechanical strength, however they are “bioinert”, which limits their bone bonding ability and osteogenic effect .…”

Section: Introductionmentioning

confidence: 99%

“…TiO 2 is one of the important bioceramics being considered to develop scaffolds for bone TE . These scaffolds show good mechanical strength, however they are “bioinert”, which limits their bone bonding ability and osteogenic effect . There are various methods reported in literature to impart bioactivity (or bio reactivity) to TiO 2 scaffolds .…”

Section: Introductionmentioning

confidence: 99%

“…These scaffolds show good mechanical strength, however they are “bioinert”, which limits their bone bonding ability and osteogenic effect . There are various methods reported in literature to impart bioactivity (or bio reactivity) to TiO 2 scaffolds . Loca et al reported the in vitro bioactivity of porous TiO 2 scaffolds coated with TiO 2 nanopowder .…”

Section: Introductionmentioning

confidence: 99%

“…There are various methods reported in literature to impart bioactivity (or bio reactivity) to TiO 2 scaffolds . Loca et al reported the in vitro bioactivity of porous TiO 2 scaffolds coated with TiO 2 nanopowder . Verket et al reported the effect of TiO 2 scaffolds coated with TiO 2, SiO 2 , and CaP on osteoblast differentiation .…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Sengottuvelan

Mederer

Boccaccını

2018

Int J Applied Ceramic Tech

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Three dimensional titanium dioxide (TiO 2 ) scaffolds are receiving attention for the reconstruction of damaged bone tissue. Although these scaffolds show sufficient mechanical properties, their bioactivity is significantly lower than that of bioactive glass scaffolds. Sol-gel derived mesoporous bioactive glasses exhibit high bioactivity in vitro and can also be loaded with drugs and growth factors due to their tunable pore size. Hence, the main aim of this work is to produce and characterize TiO 2 scaffolds coated with sol-gel derived mesoporous calcium silicate spheres (MCS) and to test their in vitro bioactivity and drug delivery properties. TiO 2 scaffolds were coated with different wt% of MCS using a simple dip coating method. The bioactivity of the MCS-coated TiO 2 scaffolds was tested in vitro in simulated body fluid (SBF). TiO 2 scaffolds coated with 2 wt% and 4 wt% MCS showed bioactivity after 1 week of immersion in SBF. The formation of hydroxyapatite (HA) was confirmed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction analysis (XRD). Ibuprofen drug loading and release rate were investigated in MCS and MCS coated TiO 2 scaffolds. A 3 weeks in vitro drug release test was performed and the amount of drug released by MCS was measured by UV-Vis spectroscopy. The MCS were successfully loaded with Ibuprofen, as model drug. Sustained drug release was measured, proving the applicability of MCS as drug delivery carriers. Thus, TiO 2 scaffolds with enhanced functionalities were produced exploiting MCS coating. K E Y W O R D Sbioactivity, drug release, ibuprofen, mesoporous calcium silica coatings, scaffold, titania

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Sengottuvelan

Mederer

Boccaccını

2018

Int J Applied Ceramic Tech

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“…CaF 2 is one of the solid lubricants, and an excellent high temperature lubricating powder . Through the powder surface coating, the uniform mixing of CaF 2 particles with different phase particles can be achieved, which can effectively improve the material properties and give it new physical, chemical and other special functions through coating …”

Section: Introductionmentioning

confidence: 99%

An advanced self‐lubricating ceramic composite with the addition of core‐shell structured CaF₂@Al₂O₃ powders

Chen

Guo

et al. 2018

Int J Applied Ceramic Tech

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Aiming to improve the performance of self-lubricating ceramic tools, an advanced self-lubricating ceramic composite was developed. Core-shell structure CaF 2 @Al 2 O 3 powders were synthesized by liquid-phase non-uniform nucleation method. Al 2 O 3 /Ti(C,N)/CaF 2 @Al 2 O 3 composite made by adding CaF 2 @Al 2 O 3 powders exhibited notable improvements in microstructure and mechanical properties as compared with Al 2 O 3 /Ti(C,N)/CaF 2 composite made by adding uncoated CaF 2 powders. The core-shell coated self-lubricating ceramic tool with different content of CaF 2 @Al 2 O 3 was designed and prepared by hot pressing sintering process. The results show that when the content of CaF 2 @Al 2 O 3 is 10 vol%, The composite has the best mechanical properties, the flexural strength, and the fracture toughness and the hardness is 680 MPa, 6.50 MPa·m 1/2 , and 17.29 GPa.Compared with the tool material with only CaF 2 solid lubricant added, the above performances were increased by 8.91%, 29.48%, and 14.50% respectively. The influence of different CaF 2 @Al 2 O 3 content on the physical and mechanical properties and microstructure of the tool material was analyzed. K E Y W O R D Score -shell cladding structure, performance test, self-lubricating ceramic tool

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Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds

Koushik

Miller

Antunes

2023

Adv Healthcare Materials

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Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, and the understanding of bone healing pathways have opened new avenues of research. The dual responsibility of BTE scaffolds in providing load‐bearing capability and interaction with the local extracellular matrix to promote bone healing is a challenge in synthetic scaffolds. This article describes the usage and processing of multi‐materials and hierarchical structures to mimic the structure of natural bone tissues to function as bioactive and load‐bearing synthetic scaffolds. The first part of this literature review describes the physiology of bone healing responses and the interactions at different stages of bone repair. The following section reviews the available literature on biomaterials used for BTE scaffolds followed by some multi‐material approaches. The next section discusses the impact of the scaffold's structural features on bone healing and the necessity of a hierarchical distribution in the scaffold structure. Finally, the last section of this review highlights the emerging trends in BTE scaffold developments that can inspire new tissue engineering strategies and truly develop the next generation of synthetic scaffolds.

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The effect of TiO2 nanopowder coating on in vitro bioactivity of porous TiO2 scaffolds

Cited by 14 publications

References 14 publications

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

An advanced self‐lubricating ceramic composite with the addition of core‐shell structured CaF₂@Al₂O₃ powders

Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds

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The effect of TiO2 nanopowder coating on in vitro bioactivity of porous TiO2 scaffolds

Cited by 14 publications

References 14 publications

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO2 scaffolds and their drug releasing behavior

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO2 scaffolds and their drug releasing behavior

An advanced self‐lubricating ceramic composite with the addition of core‐shell structured CaF2@Al2O3 powders

Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds

Contact Info

Product

Resources

About

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

Preparation and characterization of mesoporous calcium‐doped silica‐coated TiO₂ scaffolds and their drug releasing behavior

An advanced self‐lubricating ceramic composite with the addition of core‐shell structured CaF₂@Al₂O₃ powders