The Effect of Tilmicosin on Cardiac Superoxide Dismutase and Glutathione Peroxidase Activities

Yazar, Enver; Altunok, Vahdettin; Elmas, Muammer; Traş, Bünyamin; Baş, Ahmet Levent; Özdemir, Vural

doi:10.1046/j.1439-0450.2002.00545.x

Cited by 20 publications

(13 citation statements)

References 7 publications

(7 reference statements)

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“…Reduced GSH concentration of mice treated with tilmicosin alone in the organs could increase the burden on the cellular oxidant state since GSH is an important part of antioxidant defense system which plays an important role in preventing harmful effects of free radicals by scavenging hydroxyradicals and singlet oxygen (Wu et al 2004). Similar to our results, Yazar et al (2002) reported that tilmicosin decreased superoxide dismutase and glutathione peroxidase levels in the heart tissue of mice treated with tilmicosin. Another study reported that while administration of tilmicosin at 75 mg/kg dose had no effect on cardiac MDA and GSH, it increased MDA and GSH concentration in the liver tissue (Yazar et al 2004) .…”

Section: Discussionsupporting

confidence: 92%

“…It is possible for humans to be affected by tilmicosin toxicity due to a small amount of accidental injection (McGuigan 1994;Von Essen et al 2003). It was reported that a single injection of 25 mg/kg of tilmicosin resulted in decreased superoxide dismutase and glutathione peroxidase in the heart tissue of mice (Yazar et al 2002), suggesting that tilmicosin may cause oxidative stress by decreasing antioxidant enzymes in cardiac tissue.…”

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confidence: 99%

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Protection through L-Carnitine on Tissue Oxidant Status and Sialic Acid Content in Tilmicosin-Induced Alterations in BALB/c Mice

et al. 2007

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The macrolide antibiotic tilmicosin is known to induce cardiotoxic effect when administered at large doses. In this work, the effects of tilmicosin were evaluated with respect to alterations in total sialic acid, malondialdehyde and glutathione content of the heart, liver, kidney and lung tissues after single subcutaneous injection of 75 mg/kg tilmicosin with or without L-carnitine (500 mg/kg for 5 days daily via s.c. route) in BALB/c mice. L-carnitine is a co-factor serving in the mitochondrial β-oxidation of long chain fatty acids, and it was reported to be protective in several types of toxicity cases probably via multi-factorial mechanisms. Twenty eight mice were divided into 4 groups including group 1 (control), group 2 (L-carnitine), group 3 (tilmicosin) and group 4 (tilmicosin plus L-carnitine). Following the administration of treatments, tissue samples were collected, and the samples were assayed for malondialdehyde, glutathione and total sialic acid content. Mice receiving tilmicosin treatment alone had significantly higher malondialdehyde and total sialic acid concentrations (except for MDA of lungs) but lower glutathione concentration in selected tissues compared to those of the control, group 2 (Carnitine only) and group 4 (L-carnitine plus tilmicosin) (p < 0.05). However, no significant difference was found associated with the assayed indicators between the control and mice treated with L-carnitine plus tilmicosin. These results suggest that tilmicosin may cause oxidative stress in the heart, liver, lung and kidneys, but the adverse effects could be attenuated by L-carnitine administration.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

Protection through L-Carnitine on Tissue Oxidant Status and Sialic Acid Content in Tilmicosin-Induced Alterations in BALB/c Mice

et al. 2007

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“…In humans, accidental injection of the veterinary drug Micotil 300 Ò could result in chest pain, alterations in electrocardiogram and cardiac enzyme levels including elevation of creatine kinase (CK) and CK-MB (CK-MB) (Von Essen et al, 2003). Previous studies clearly indicate that tilmicosin may cause elevation of cardiac enzymes (Yazar et al, 2002a) and oxidative stress (Yazar et al, 2002b) by decreasing antioxidant enzymes or by depressing synthesis of these enzymes in the cardiac tissue.…”

Section: Introductionmentioning

confidence: 99%

The Possible Protective effect of L‐carnitine on Tilmicosin‐induced Cardiotoxicity in Mice

Kart¹,

Yapar²,

Karapehlivan³

et al. 2007

Journal of Veterinary Medicine Series A

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The protective effect of L-carnitine was investigated against tilmicosin-induced cardiotoxic effects including blood creatine kinase (CK), CK-MB, total sialic acid as well as the alterations in glutathione and malondialdehyde concentrations in mice. Thirty-two Balb/C mice were divided into four groups including group 1 (control), group 2 (L-carnitine, s.c., 500 mg/kg for 5 days), group 3 (tilmicosin, s.c., single dose of 75 mg/kg) and group 4 (L-carnitine plus tilmicosin). Serum CK, CK-MB and malondialdehyde (MDA) levels were significantly (P < 0.05) higher in group 3 compared with those of other groups. Total sialic acid level in group 3 was found to be significantly (P < 0.05) higher than that in groups 1 and 2, as well. Contrary to these results, glutathione level in group 3 was found to be significantly (P < 0.05) lower than that in groups 1 and 2. In group 4, serum CK, CK-MB, MDA and total sialic acid levels were found to be significantly (P < 0.05) lower than those in group 3. These results suggest that tilmicosin is cardiotoxic in mice as evidenced by higher total sialic acid, CK and CK-MB. In addition, tilmicosin caused the decrease in glutathione and increase in MDA levels. However, administration of L-carnitine could ameliorate these adverse toxic effects of tilmicosin in mice.

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“…The effects of macrolide antibiotics on antioxidant status have been reported previously. Tilmicosin, another macrolide antibiotic, increased the level of MDA (Yazar et al, 2004;Kart et al, 2007) and decreased SOD activity (Yazar et al, 2002a). Increased SOD activity may be derived from oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of macrolide antibiotics on oxidative (Yazar et al, 2002a(Yazar et al, , 2004Ueno et al, 2005;Kumar et al, 2008), coagulation status (Purdy et al, 2002;Bouwman et al, 2004) and organ damage markers have been investigated in healthy and sick individuals. However, to the best of our knowledge, the effect of tulathromycin on the oxidative and coagulation status of the blood has not been researched.…”

Section: Introductionmentioning

confidence: 99%

Tulathromycin disturbs blood oxidative and coagulation status

Ulutaş²,

Altan³

et al. 2011

Afr. J. Biotechnol.

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The aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and -carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period.

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The Effect of Tilmicosin on Cardiac Superoxide Dismutase and Glutathione Peroxidase Activities

Cited by 20 publications

References 7 publications

Protection through L-Carnitine on Tissue Oxidant Status and Sialic Acid Content in Tilmicosin-Induced Alterations in BALB/c Mice

Protection through L-Carnitine on Tissue Oxidant Status and Sialic Acid Content in Tilmicosin-Induced Alterations in BALB/c Mice

The Possible Protective effect of L‐carnitine on Tilmicosin‐induced Cardiotoxicity in Mice

Tulathromycin disturbs blood oxidative and coagulation status

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