The Effect of Three Months of Resistance Training on TCF7L2 Expression in Pancreas Tissues of Type 2 Diabetic Rats

Eizadi, Mojtaba; Ravasi, Ali Asghar; Soory, Rahman; Baesi, Kazem; Choobineh, Siroos

doi:10.17795/ajmb-34014

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…Then type 2 diabetes was induced by intra-peritoneal injection using nicotinamide injection at a dose of 110 mg / kg body weight and streptozotocin at a dose of 60 mg / kg in diabetic groups. One week after diabetes induction, fasting blood glucose and glucose levels between 150 and 400 mg / dL were considered as a measure to ensure that mice were diagnosed with type 2 diabetes (18). Before applying the training program to homogenize the two training and the control groups, measurement was done using a weighing scale for Japanese animals (accurately 0.01 g).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

Ardakani

Abednatanzi

Gholami

et al. 2020

IJDO

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Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats. Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups. Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001). Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.

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Section: Methodsmentioning

confidence: 99%

The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

Ardakani

Abednatanzi

Gholami

et al. 2020

IJDO

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show abstract

“…The role of transcription factors such as FTO, FOXO1, IRS-1, PPARgama, and GLUT4 in insulin-dependent glucose transport has been previously reported (8,10,11,14). In this regard, the PTP1B gene is of particular importance (8) as some researchers have identified it as a regulator of insulin function in mammals and a pharmacological target in T2D (1). It is worth mentioning that the findings of the present study indicated a decrease in blood glucose and insulin resistance levels along with a decrease in PTP1B expression in gastrocnemius muscle in response to interval training in T2D rats.…”

Section: Discussionmentioning

confidence: 49%

“…Although T2D is a multifactorial disease, one of its prominent risk factors is the prevalence of obesity. Consideration of obesity as one of the most important factors contributing to the development of T2D has been supported by some previous studies (1,2).…”

Section: Introductionmentioning

confidence: 65%

“…It should be noted that a high-fat diet was continued to the end of the study for 2 groups. Hyperglycemia was confirmed by elevated blood glucose levels on day 7 after diabetes induction and only animals with fasting blood glucose level between 150 and 400 mg/dL were selected to serve as T2D rats and used in the study (13).…”

Section: Induction Of Type 2 Diabetesmentioning

confidence: 99%

“…The pathogenesis of type 2 diabetes (T2D) is associated with genetic mutations, heredity, obesity, and obesityrelated abnormalities that predispose the individuals to insulin resistance (1). Although T2D is a multifactorial disease, one of its prominent risk factors is the prevalence of obesity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of 8-Week Interval Training on Protein Tyrosine Phosphatase 1B Expression in Gastrocnemius Muscle and Insulin Resistance in Rats with Type 2 Diabetes

Eizadi

Mirakhori

Behrestaq

2019

Avicenna J Med Biochem

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Background: Insulin resistance induced by genetic and metabolic disorders is the main cause of the prevalence or severity of type 2 diabetes (T2D). Protein tyrosine phosphatase 1B (PTP1B) plays a key role in regulating glucose homeostasis as a negative regulator of insulin signaling pathway. Objectives: This study aimed to assess the effect of interval training on PTP1B expression in gastrocnemius muscle and insulin resistance in male rats with T2D. Methods: T2D was induced by high fat diet (HFD) and intraperitoneal injection of STZ in 14 male Wistar rats and then they were divided randomly into exercise (n=7) or control (n=7) groups. Exercise rats completed an 8 weeks interval training (5 days/week) and control rats remained without training. Fasting glucose, serum insulin, and PTP1B expression in gastrocnemius muscle were measured 48 hours after the last exercise session. Insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR) formula based on fasting insulin and glucose levels. An independent t test was used to compare each parameter between 2 groups. A P value less than 0.05 was considered statistically significant. Results: Interval training resulted in a significant decrease in fasting glucose level (P<0.0001) and insulin resistance (P=0.018) as well as an increase in serum insulin level (P<0.0001). PTP1B expression in gastrocnemius muscle decreased significantly compared with control rats (P=0.003) Conclusion: Interval training can improve insulin resistance in T2D rats. This improvement may be attributed to the decrease in PTP1B expression in gastrocnemius muscle by interval training.

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Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats

2021

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The Effect of Three Months of Resistance Training on TCF7L2 Expression in Pancreas Tissues of Type 2 Diabetic Rats

Abstract: Background: Resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (T2D); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them.

Cited by 5 publications

References 43 publications

The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

Effect of 8-Week Interval Training on Protein Tyrosine Phosphatase 1B Expression in Gastrocnemius Muscle and Insulin Resistance in Rats with Type 2 Diabetes

Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats

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