The Effect of Thiouracil and Thyroid Extract on the Natural Resistance of Mice to Hymenolepis Infection

Larsh, John E.

doi:10.2307/3273175

Cited by 23 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to the effect of thyroxine overdosage on resistance to infection, the findings in this study are similar to those previously reported in experiments on mice infected with hemolytic staphylococci (30), tubercle bacilli (31), eggs of Hymenoletyis nana (32), and murine pneumonitis virus (33).…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Thyroid Function in Experimental Streptococcal Pneumonia in the Rat

Reichlin

Glaser

1958

The Journal of Experimental Medicine

View full text Add to dashboard Cite

In order to study the effects of a severe bacterial infection on thyroid function rats were subjected to group A streptococcal pneumonia, and thyroid activity determined by measurement of the rate of discharge of I131 from the thyroid gland. Decreased thyroid activity of moderate to marked degree was observed in the majority of infected animals. Infected animals ate less than normal animals. Since fasting leads to decreased thyroid function, I131 release rates were measured in control animals pair-fed with infected animals and in control and infected animals force-fed a normal intake. The reduction in thyroid activity seen in acute infection was found to be partly but not entirely due to the associated voluntary food restriction. Although the adrenal glands of rats dying of pneumonia were very large, the thyroid inhibition occurring during the course of experimental pneumonia was not secondary to increased adrenocortical function since infected, adrenalectomized animals, receiving injections of cortisone, showed thyroid inhibition comparable to that observed in intact infected animals. The possible influence of the level of thyroid activity on resistance was evaluated. In two experiments a total of 80 rats in 3 groups was pretreated with propylthiouracil and injected daily with 3 dosage levels of 7-thyroxine for 3 weeks prior to inoculation. Under these conditions mortality rates in infected animals fell with decreasing levels of thyroid function. However, induced hypothyroidism was found to afford no protective effect in comparison with untreated infected animals.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Reduced thyroid activity resulted in increased resistance of mice to routine pneumonitis virus (33) and to infestation by Hymenolep~is nana (32). On the Other hand, induced hypothyroidism resulted in reduced resistance of mice to poliomyelitis virus (37), and of rats to infestation with No~oedres rauris (38).…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function in Experimental Streptococcal Pneumonia in the Rat

Reichlin

Glaser

1958

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…The finding that, in general, fewei worms developed in birds on the thyroid diet is in contrast to the report of Larsh (1947) who reported that mice fed 3 mg of thyroid daily developed more of the tapeworm Hymenolepis than their nontreated controls of the same age.…”

Section: Discussioncontrasting

confidence: 84%

Thyroactive Iodocasein and Thiouracil in the Diet, and Growth of Parasitized Chicks ,

Todd

1948

Poultry Science

View full text Add to dashboard Cite

“…) that thyroprotein in the diet may increase resistance to the effect of coccidial infection as reflected by slightly greater rate of gain following exposure, but these present data are also without statistical significance. Significantly greater oocyst counts in birds with mild hyperthyroidism are of interest in view of the work of Larsh (1947), who reported that addition of thyroid to the diet of mice stimulated development of greater numbers of the tapeworm Hymeriolepis. The possibility of a longer latent period in hyperthyroid hosts should be considered, however, since the present coccidial counts were made 3 weeks after exposure.…”

Section: Discussionmentioning

confidence: 96%