1958
DOI: 10.1084/jem.107.2.219
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Abstract: In order to study the effects of a severe bacterial infection on thyroid function rats were subjected to group A streptococcal pneumonia, and thyroid activity determined by measurement of the rate of discharge of I131 from the thyroid gland. Decreased thyroid activity of moderate to marked degree was observed in the majority of infected animals. Infected animals ate less than normal animals. Since fasting leads to decreased thyroid function, I131 release rates were measured in control animals pa… Show more

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Cited by 31 publications
(13 citation statements)
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“…Observations in animals, of a decreased serum PBI during acute infection followed by a later rebound, are compatible with the transient depression of thyroidal 'I release rates observed in these species (2,5,6,(24)(25)(26). Modest decreases in PBI have been observed during infection in man as well, again often demonstrating a rise to normal limits or greater during recovery (4,(8)(9).…”
Section: Methodssupporting
confidence: 56%
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“…Observations in animals, of a decreased serum PBI during acute infection followed by a later rebound, are compatible with the transient depression of thyroidal 'I release rates observed in these species (2,5,6,(24)(25)(26). Modest decreases in PBI have been observed during infection in man as well, again often demonstrating a rise to normal limits or greater during recovery (4,(8)(9).…”
Section: Methodssupporting
confidence: 56%
“…These workers invoked an increase in thyroidal secretion of To during acute infection, in view of an increased (k) in the face of no change in T, distribution space or PBI. However, an enhanced rate of To secretion is not supported by studies demonstrating suppressed thyroidal "II release during infection in various species (2,3,(24)(25)(26), or by ratios for urinary 'I/I in the present study (Fig. 6), which indicate inhibition of hormonal release.…”
Section: Methodscontrasting
confidence: 49%
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“…That nonthyroidal illness is associated with a reduction in pituitary-thyroid function has been apparent for many years [1][2][3][4] but the mechanism by which this abnormality comes about is only recently becoming understood. An animal model of nonthyroidal illness that has similarities 5i VEH IL-1 to the more severe forms of human nonthyroidal illness is infectious disease, associated with low serum T4 and Ti levels and inappropriately normal or low TSH levels.…”
Section: Discussionmentioning
confidence: 99%
“…Leukocytes isolated from blood obtained Received for publication 9 July 1970 and in revised form 7 November 1970. ronine (TB) in several animal species, the results of such studies tend to be conflicting, appearing to vary with the nature of the species examined. In the rat, for example, acute streptococcal and pneumococcal infections appear to result in a depression of thyroid function (1,2), whereas in man data obtained after treatment of acute pneumococcal pneumonia had been instituted suggest that an increase in thyroid function might accompany this type of stress (3).…”
mentioning
confidence: 99%