The effect of the somatostatin analogue lanreotide on the prevention of urethral strictures in a rabbit model

Abstract

We evaluated the effect of the somatostatin analogue lanreotide on the development of surgically induced experimental strictures in the anterior urethra of the male rabbit. A total of 74 male rabbits were randomly allocated into four groups. Lanreotide was administered to the rabbits in groups 2 and 4 from day 0 to 14. To create a stricture, a resection was made in the urethra of the rabbits in groups 3 and 4 on day 2. On day 30, all rabbits were examined with urethrography, impedance planimetry and either histology or for collagen content. Urethrography and impedance planimetry demonstrated a urethral stricture in all operated animals. No difference was found between the two stricture groups, regardless of lanreotide administration, with respect to luminal cross-sectional area (CSA), circumferential tension-strain relation, histology or collagen content. The CSA of the urethra of the normal controls treated with lanreotide was smaller than the CSA of the normal controls not treated with lanreotide, however, no difference was found in histology or collagen content. Lanreotide had no measurable effect on the development of a surgically induced stricture in the male rabbit anterior urethra, however, lanreotide seems to exert an inhibitory effect on the normal growth of the urethra.

The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence

“…Spongiofibrosis occurs in varying degrees and narrows the urethral luminal caliber. So that there are some ideas of treating the fibrosis with antifibrotic agents such as halofugione, mitomycin C, bitoxin A, somatostatin analogues, captopril and steroids (11,(19)(20)(21)(22)(23).…”

A Comparative Study of Optical Internal Urethrotomy Alone With Optical Internal Urethrotomy Plus Steroid for Anterior Urethral Stricture Disease

“…[8,9] The main pathogenesis of stricture is the fibrosis formation caused by excessive collagen synthesis and changes in the extracellular matrix of the urethral lumen due to the endoscopic instrumentation, trauma and infections. Spongiofibrosis occurs in varying degrees and narrows the urethral lumen so that there are some ideas to treating the fibrosis with antifibrotic agents such as hyaluronidase, mitomycin C, bitoxin A, [19] captopril, [20] docetaxel, [21] somatostatin analogues [22] and steroids. There are many studies that have come with OIU along with injection triamcinolone.…”

Numerical Analysis of Deformation and Flow in the Proximal Area of the Urethra

“…The maximum urinary pressure was 4kPa [26,32]. In the literature, this value appears many times, hence, it is possible to compare the results obtained by other authors in the experimental and model studies [23,32,[37][38][39]. In the scope of the CFD flow dynamics analysis, the methodology of calculations, appropriate boundary and beginning conditions as well as the structure and fluid properties were proposed.…”