The article is devoted to the study of the influence of new promising drugs «Nanosilicon», «Stimulin» and «Alfastim» on the rhizogenesis of green cuttings of sea buckthorn when growing planting material. The objects of the study were three promising varieties of sea buckthorn selected by the Research Institute of Horticulture of Siberia: Augustina, Essel and Etna. The purpose of the research is to search for drugs and optimal concentrations that stimulate root formation to increase the yield of high-quality planting material of valuable sea buckthorn varieties. As a result of the conducted research, the positive effect of the drug mineral fertilizer with microelements «Nanosilicon» on the rhizogenesis of green cuttings and the volume of the root system of sea buckthorn seedlings was established.