The effect of the preoperative uric acid level and neutrophil lymphocyte ratio on preoperative and postoperative visual pain scores in patients with lumbar disc hernia: a cross-sectional study.

Abstract

AIM:To determine the relationship between the serum urate (SU) level, neutrophil / lymphocyte ratio (NLR), and pain severity using preoperative and postoperative visual analogue scale (VAS) scores in patients with lumbar disc herniation (LDH). MATERIAL and METHODS:This single-center, cross-sectional study included 20 consecutive patients who were operated for LDH by the same surgeon. The patients'pre-and postoperative UA levels, NLRs, and intensity severity VAS scores were investigated. Preoperative magnetic resonance imaging (MRI) findings, serum UA levels, and neutrophil and lymphocyte counts were recorded. Pain severity was recorded preoperatively and at 6 months postoperatively. Effects of the preoperative SU levels and NLRs on the pre-and postoperative VAS scores were statistically assessed. RESULTS:Statistically significant positive correlation coefficients were determined between NLR and the preoperative and postoperative VAS scores. Negative correlation coefficients were found between the SU levels and preoperative VAS scores; in contrast, positive correlation coefficients were found between the SU levels and the postoperative VAS scores. CONCLUSION:Our results demonstrate the importance of not ignoring the serum UA level and NLR in pre-and postoperative pain in patients with LDH. Nevertheless, further extensive studies are warranted.

The Roles of Blood Lipid-Metabolism Genes in Immune Infiltration Could Promote the Development of IDD

“…Besides, it behaved wide range of effect mechanisms against pathogens, including phagocytosis, and the production of reactive oxygen species, proteases, and neutrophil extracellular traps formation ( Nathan, 2006 ). Our findings that neutrophils were up-regulated in IDD patients were consistent with previous research: a cross-sectional study about neutrophil/lymphocyte ratio (NLR) by Bozkurt, et al reported a significant correlation between NLR and pre- and post-operative VAS scores of IDD patients under surgery ( Bozkurt et al, 2019 ). As the largest avascular organ, IVD is considered as immune-privilege organ due to its special structure, accumulating evidences suggested the mechanism which limited immunocytes and immune mediators entering NP tissue in IVD could be defined as blood-NP barrier, a complex composition of physical and molecular factors ( Sun et al, 2020 ), while blood vessels were crucial channel of immunocytes infiltration ( Johnson et al, 2005 ).…”

Does Preoperative Neutrophil-Lymphocyte Ratio Predict Patient-Reported Pain and Functional Outcomes at 12 Months After Lumbar Fusion?

“…Furthermore, Bozkurt et al reported a moderate positive correlation between preoperative NLR and postoperative VAS scores. 15 The disparity between our findings and those of Bozkurt et al may be due to differences in our assessment of the outcome measures. Bozkurt et al used the VAS score at 6 months after surgery as their outcome measure and did not define a threshold improvement in VAS score that signifies that the patient benefited from the surgery.…”

Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?

“…Recently, Yılmaz et al reported that NLR was an independent predictor in patients with lumbar disc hernia and low back pain [ 20 ]. Similarly, another study showed that preoperative and postoperative pain was more severe among patients with lumbar disc hernia and a higher NLR level, as an indicator of inflammation [ 24 ]. Dagistan et al found no significant difference between serum NLR and PLR levels of the LDH patients and healthy controls [ 25 ].…”