The Effect of the Local and Oral Administration of Cod Liver Oil on the Rate of Wound Healing in Vitamin a-Deficient and Normal Rats*

Brandaleone, Harold; Papper, E. M.

doi:10.1097/00000658-194111440-00020

Cited by 5 publications

(5 citation statements)

References 1 publication

(1 reference statement)

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“…A previous study has shown that in skin wound sites where basal cell proliferation is increased, levels of HB‐EGF proteins were found to be elevated in differentiated suprabasal keratinocytes (McCarthy et al ., 1996). On the other hand, it has been known for over half a century that vitamin A deficiency causes delayed wound healing (Brandaleone and Papper, 1941; Hunt, 1970). Pretreatment with vitamin A and tRA was reported to improve skin wound healing in animals and humans (Strigini and Ryan, 1996 and references therein).…”

Section: Discussionmentioning

confidence: 99%

Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors

Xiao

Feng²,

Di³

et al. 1999

The EMBO Journal

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The role of retinoic acid receptors (RARs) in intercellular regulation of cell growth was assessed by targeting a dominant-negative RARα mutant (dnRARα) to differentiated suprabasal cells of mouse epidermis. dnRARα lacks transcriptional activation but not DNAbinding and receptor dimerization functions. Analysis of transgenic mice revealed that dnRARα dose-dependently impaired induction of basal cell proliferation and epidermal hyperplasia by all-trans RA (tRA). dnRARα formed heterodimers with endogenous retinoid X receptor-α (RXRα) over RA response elements in competition with remaining endogenous RARγ-RXRα heterodimers, and dose-dependently impaired retinoiddependent gene transcription. To identify genes regulated by retinoid receptors and involved in cell growth control, we analyzed the retinoid effects on expression of the epidermal growth factor (EGF) receptor, EGF, transforming growth factor-α, heparin-binding EGFlike growth factor (HB-EGF) and amphiregulin genes. In normal epidermis, tRA rapidly and selectively induced expression of HB-EGF but not the others. This induction occurred exclusively in suprabasal cells. In transgenic epidermis, dnRARα dose-dependently inhibited tRA induction of suprabasal HB-EGF and subsequent basal cell hyperproliferation. Together, our observations suggest that retinoid receptor heterodimers located in differentiated suprabasal cells mediate retinoid induction of HB-EGF, which in turn stimulates basal cell growth via intercellular signaling. These events may underlie retinoid action in epidermal regeneration during wound healing.

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Section: Discussionmentioning

confidence: 99%

Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors

Xiao

Feng²,

Di³

et al. 1999

The EMBO Journal

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“…Tretinoin (all‐trans‐retinoic acid), a derivative of vitamin A (retinol), has been used as a keratolytic agent in the topical treatment of acne 40 as well as a number of other keratinizing disorders 41 . Vitamin A has been linked with wound healing for over 50 years 42–47 . Recently, pretreatment with tretinoin cream has been shown clinically to accelerate the reepithelialization of dermabrasion wounds in man 48 and partial‐thickness 49 and full‐thickness 50 wounds in animals.…”

Section: Discussionmentioning

confidence: 99%

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

Watcher

Wheeland

1989

The Journal of Dermatologic Surgery and Oncology

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Eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. The following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. The rate of reepithelialization was significantly enhanced by treatment with capsaicin, bacitracin, silver sulfadiazine, and scarlet red, and was markedly retarded by treatment with tretinoin. Wound contraction was significantly retarded by mupirocin, bacitracin, and silver sulfadizine. Knowledge of the effects of topical agents on various aspects of healing allows the clinician to choose the most appropriate material to use in a given clinical situation to optimize the healing process and produce the best final result.

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“…[3][4][5] Studies examining the role of vitamin A in the structured sequence of wound repair have been conducted for more than 50 years. 6 The effect of retinoids on epithelial cells has been extensively evaluated. 7,8 In contrast there have been relatively few studies on the influence of retinoids on dermal tissue.…”

mentioning

confidence: 99%

The effect of topical tretinoin on tissue strength and skin components in a murine incisional wound model

Muehlberger

Moresi

Schwarze

et al. 2005

Journal of the American Academy of Dermatology

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The Effect of the Local and Oral Administration of Cod Liver Oil on the Rate of Wound Healing in Vitamin a-Deficient and Normal Rats*

Cited by 5 publications

References 1 publication

Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors

Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

The effect of topical tretinoin on tissue strength and skin components in a murine incisional wound model

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