“…If the amphetamine cue is related to subjective effects in humans, similar agents should also block amphetamine-induced euphoria. However, in most studies the D 2 antagonist, pimozide, did not block amphetamine-induced euphoria in humans (Silverstone et al 1980;Jacobs and Silverstone 1986;de Wit 1995, 1996a,b), and the mixed D 1 /D 2 antagonist, fluphenazine, also failed to block these effects (Brauer and de Wit 1995). Similarly, if the discriminative stimulus effects of amphetamine are related to its euphorigenic effects, then D 2 agonists and some DA uptake inhibitors should mimic the subjective effects of amphetamine.…”