1968
DOI: 10.1016/0002-8703(68)90258-5
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The effect of the dextro isomer of propranolol on sinus rate and cardiac arrhythmias

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Cited by 27 publications
(5 citation statements)
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“…In the isolated rat heart, d-propranolol was as effective as racemic beta-adrenergic antagonists in preventing arrhythmias after coronary occlusion (33) and subsequent reperfusion (34). In small groups of patients, there have been anecdotal reports ihat d-propranolol can suppress premature atrial and ventricular depolarizations (35,36). However, none of these investigations explored the mechanism of its antiarrhythmic actions.…”
Section: Discussionmentioning
confidence: 99%
“…In the isolated rat heart, d-propranolol was as effective as racemic beta-adrenergic antagonists in preventing arrhythmias after coronary occlusion (33) and subsequent reperfusion (34). In small groups of patients, there have been anecdotal reports ihat d-propranolol can suppress premature atrial and ventricular depolarizations (35,36). However, none of these investigations explored the mechanism of its antiarrhythmic actions.…”
Section: Discussionmentioning
confidence: 99%
“…In view of its effects in controlling dysrhythmias in animals and patients undergoing anaesthesia (Howitt et al, 1968), it seems possible that this isomer will prove as effective as the DL mixture and certainly justifies further clinical trial. We gave it in larger doses and with less myocardial depression than racemic propranolol to 13 patients with recent myocardial infarction.…”
Section: Discussionmentioning
confidence: 99%
“…D-Propranolol possesses considerable antidysr&hythmic activity and will rapidly revert ouabain-induced tachycardia in dogs and cats to sinus rhythm (Howe and Shanks, 1966). Howitt was able to control various dysrhythmias in 59 patients (Howitt, Husaini, Rowlands, Logan, Shanks, and Evans, 1968) and reported that 5-20 mg. of dextropropranolol given intravenously was as effective as the racemic drug in treating ventricular and supraventricular ectopic beats. In six of his patients the dextro-isomer terminated digitalisinduced dysrhythmias.…”
mentioning
confidence: 99%
“…In the use of propranolol in this arrhythmia, it appears that the direct membrane action is responsible for reversion to sinus mechansim and the beta-blocking action reduces nodal conduction. 29 , 41 Since it is well established that fatal ventricular arrhythmias can follow the use of direct-culTent countershock in the presence of excessive or even normal amounts of digitalis,44 the use of propranolol, diphenylhydantoin, or lidocaine is superior to electrical conversion in patients with sustained supraventricular or ventricular tachycardias which might be caused by digitalis.…”
Section: Clinical Pharmacology and Therapeuticsmentioning
confidence: 99%