The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in Pregnancy

Mertoğlu, Cuma; Günay, Murat; Siranli, Gulsah; Külhan, Mehmet; Gök, Gamze; Erel, Özcan

doi:10.1080/15513815.2018.1453002

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Dynamic thiol/disulfide homeostasis is an important indicator of OS. 28,29 In our study, we found that plasma-native and total-thiol levels were significantly reduced and that disulfide levels were significantly increased in the IBS group compared to healthy children. Disulfide/total thiol percentages were higher in IBS patients than in healthy controls, and the native thiol/total thiol percentage was significantly reduced in IBS patients.…”

Section: Discussionsupporting

confidence: 47%

“…Thiols are an important part of the antioxidant defense system, and reversible disulfide bonds are formed with the oxidation of thiols. Dynamic thiol/disulfide homeostasis is an important indicator of OS 28,29 . In our study, we found that plasma‐native and total‐thiol levels were significantly reduced and that disulfide levels were significantly increased in the IBS group compared to healthy children.…”

Section: Discussionmentioning

confidence: 47%

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Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

Durankuş¹,

Şenkal²,

Cam³

et al. 2021

Pediatrics International

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Background: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 47%

Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

Durankuş¹,

Şenkal²,

Cam³

et al. 2021

Pediatrics International

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“…There are several studies investigating association between TDH and gestational diabetes mellitus [94][95][96][97]. It has been demonstrated that NT and TT levels were found to be lower than control subjects and decreased NT levels have an increased risk of possible adverse perinatal outcomes [95].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

“…Authors have suggested that infants of obese or diabetic mothers are exposed to increased oxidative stress [94]. In another study, authors have demonstrated that 50 grams glucose challenge test-positive pregnant women have increased disulfide levels after glucose loading compared to baseline [97].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…In many different clinical conditions, TDH was examined to show the severity of oxidative stress and significant results were found [18][19][20][21][22][23]. In our study, it was found that total thiol and native thiol levels were significantly lower in DKA.…”

Section: Discussionmentioning

confidence: 55%

Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis

et al. 2021

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The aim of present study was to investigate the dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis (DKA). Materials and methods:A total of 77 participants consisting of 32 patients with DKA and 45 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] were measured in both groups (patient group and control group) using a brand new method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. Results: Total thiol, native thiol, and disulfide levels in blood were found to be low. The levels of total thiol (P < 0.001) and native thiol (P < 0.001 ) were significantly lower in patients with DKA than in the control group. At the same time, the level of disulfide was nonsignificantly lower in the patient group than the control group (P = 0.388). The level of IMA was higher in the patient group than in the control group (P < 0.001). Conclusion:The total thiol, native thiol, and disulfide levels in DKA decrease in favor of oxidative stress.

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The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in Pregnancy

Abstract: In GCT-positive pregnant individuals, the glucose load increases oxidative stress by changing the thiol/disulfide homeostasis. Such an effect is not observed in healthy pregnancies.

Cited by 12 publications

References 22 publications

Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis

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