The Effect of Testicular Torsion on the Contralateral Testis

Nagler, Harris M.; White, Ralph deVere

doi:10.1016/s0022-5347(17)53504-1

Cited by 178 publications

(98 citation statements)

References 12 publications

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“…Several experimental studies on different animal species have documented that unilateral testicular torsion can produce pathological changes in the contralateral testis (Nagler & de Vere White 1982, Reyes et al 1997) with a reduction in fertility (Chakraborty et al 1986) and abnormal Signi cant increase compared to torsion/detorsion versus torsion/orchiectomy groups sperm production (Jhunjhunwala et al 1986), as occurs in humans (Bartsch et al 1980, Anderson & Williamson 1990). The exact mechanism of damage in the contralateral testis is not clear.…”

Section: Discussionmentioning

confidence: 99%

Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

Vigueras

Reyes²,

Rojas-Castañeda³

et al. 2004

Lab Anim

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The rat is one of the most frequently selected animals for studies in urological research, including experimentally-produced testicular torsion (Dokucu et al. 2000), orchiectomy (Ashby & Lefevre 2001) and cryptorchidism (Vigueras et al. 1999).Testicular torsion, or the torsion of the spermatic cord, is a surgical emergency in humans that causes testicular injury and subfertility. It is generally accepted that unilateral testicular torsion causes contralateral testicular deterioration and results in diminished fertility (Bartsch et al.

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Section: Discussionmentioning

confidence: 99%

Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

Vigueras

Reyes²,

Rojas-Castañeda³

et al. 2004

Lab Anim

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“…Nagler and White [7], Nagler et al [8], and Merimsky et al [6] reported that unilateral testicular torsion in mature rats results in contralateral testicular damage consisting of distorted tubular architecture, decreased seminiferous tubular diameter, and no sperm cells within the tubular lumen [7,81. These authors and others [3] believe that this phenomenon appears to be immunologically mediated and can be prevented by early orchiectomy of the infarcted testis or by splenectomy plus antilymphocytic globulin.…”

Section: Discussionmentioning

confidence: 99%

Effect of Testicular Torsion on Contralateral Testis and Fertility in Mature Rats

Madgar

Lunenfeld

Mashiach

et al. 1987

Archives of Andrology

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The effect of unilateral testicular torsion on the contralateral testis and the fertility rate was studied in Charles River adult rats. Animals were divided into groups that underwent a sham operation or torsion and ligation of the left testicular vessels followed by orchiectomy after 24 h, orchiectomy after 48 h, release of the ligature after 24 h, release of the ligature after 48 h, and no further treatment following ligation. Another group of animals underwent unilateral orchiectomy. After 8 weeks animals were allowed to mate and were sacrificed 2 weeks later. The results did not point to either histological alterations in the contralateral testis or impairment of fertility in any group of treatment compared with the control.

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“…1 Furthermore, the contralateral testis can be affected and there is a risk of infertility in those cases. 2,[5][6][7] Reperfusion of the ipsilateral testis after ischemia results in overproduction of reactive oxygen species (ROS), cytokines, and adhesion molecules, as well as migration of leucocytes. 8.9 Nitric oxide (NO) -produced from L-arginine by nitric oxide synthase (NOS) -plays an important role in this process as a signaling molecule.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

Ozmerdiven

Çoşkun

Kaygısız

et al. 2017

CUAJ

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Cite as: Can Urol Assoc J 2017;11(1-2):E19-25. http://dx.doi.org/10.5489/cuaj.3872 Published online January 12, 2017 AbstractIntroduction: Nitric oxide (NO) plays an important role in the ischemia and reperfusion process. In this study, we aimed to examine the effect of L-arginine, tadalafil, and their combination for prevention of the ischemia reperfusion injury after testis torsion in rats. Methods: A total of 40 adult, male Sprague-Dawley rats were allocated into five groups. Three hours of left testicular torsion was performed in each group, excluding the control group. While the ischemia reperfusion (I/R) group had no treatment, I/R + Arg group received L-arginine, I/R + Td group received tadalafil and I/R + Arg + Td group received tadalafil and L-arginine 30 minutes before the detorsion. Then the left testis was untwisted for four hours of reperfusion. After bilateral orchiectomy, lipid peroxidation (LPx) and glutathione (GSH) activities were examined in testicular tissue. Spermatogenesis was evaluated with Johnsen's score. Results: LPx levels of the I/R group were found to be significantly higher than for groups that received drugs for both testes (p<0.001). GSH levels of the combination group were higher than I/R group in ipsilateral testis (p<0.01) and it was significantly higher than other groups for contralateral testis (p<0.001 for I/R group, p<0.01 for I/R + Arg, p<0.05 for I/R + Td). Mean Johnsen's score of the I/R group was found to be significantly lower than treatment groups in ipsilateral testis (p<0.001 for I/R + Arg + Td group, p<0.01 for other treatment goups) and contralateral testis (p<0.001). The mean Johnsen score of the combination group was significantly higher than that of other treatment groups in ipsilateral testis (p<0.05) and it was significantly higher than in the I/R + Td group in the contralateral testis (p<0.05). Conclusions: L-arginine, tadalafil, and combination of these two molecules showed protective effect against ischemia/reperfusion injury for both testes after unilateral testis torsion.

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The Effect of Testicular Torsion on the Contralateral Testis

Cited by 178 publications

References 12 publications

Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

Effect of Testicular Torsion on Contralateral Testis and Fertility in Mature Rats

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

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