The Effect of Tenoxicam on Intraperitoneal Adhesions and Prostaglandin E2 Levels in Mice

Abstract

Postoperative intraabdominal adhesions can cause intestinal obstruction, pelvic pain, or infertility. In this study, we showed that intraperitoneally administered tenoxicam decreases tissue prostaglandin E2 levels and intraabdominal adhesions in mice.

Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

“…In open surgery models for adhesion formation effectiveness of ROS scavengers, antiinflammatory drugs, and calcium-channel blockers have been shown, albeit in isolated experiments with mice [10,45], rats [4, 5, 7-9, 11-13, 16, 38-40, 42-44], hamsters [36], and rabbits [6,14,15,17,18,31,34,37,41]. In our pneumoperitoneum- enhanced adhesion mouse model, ROS scavengers (only SOD was significant), dexamethasone and a calciumchannel blocker (diltiazem) decreased adhesion formation, whereas no effect was found for NSAIDs, even for specific COX-2 inhibitors or for anti-TNF-alpha antibodies.…”

“…Antiinflammatory drugs are widely accepted for reducing adhesion formation in mice [10,91], rats [4, 5, 7-9, 11-13, 16], and rabbits [6,14,15,[17][18][19]. However, these effects have not always been consistent in open surgery models.…”

“…For Ibuprofen, 70 mg/kg IP was used because this dose was shown to be effective in rabbits [14]. For tenoxicam, 10 mg/kg IP was used because 5 mg/kg IP was shown to be effective in mice [10]. For anti-TNF-alpha, 0.01, 0.1, and 1 mg IP were used because 1 mg IP was shown to be effective in mice [83].…”

“…During open surgery, many products have been demonstrated to decrease postoperative adhesion formation, including corticosteroids, [4][5][6][7], nonsteroidal antiinflammatory drugs (NSAIDs) [6,[8][9][10][11][12][13][14][15][16][17][18][19], fibrinolytic agents [20], surfactants [21][22][23][24][25], flotation agents and semisolid barriers [23,[26][27][28], mechanical barriers [26,[29][30][31][32], hormones [33], calcium-channel blockers [34][35][36][37][38], reactive oxygen species (ROS) scavengers [39][40][41][42][43][44][45], and antiangiogenesis therapy [46,47]. It should be stressed that these observations generally were reported with the use of only one drug in different models with di...…”

Intraperitoneal Tenoxicam to Prevent Abdominal Adhesion Formation in a Rat Peritonitis Model

“…[8][9][10][11] Adhesion-preventing substances must inhibit adhesiogenesis without compromising wound healing; show efficacy, even in the presence of blood or other body fluids; have anti-inflammatory properties; be without immunogenic determinants; be biodegradable; be able to safely remain in place after application; be easy to handle; and have an immediate effect. [12][13][14] The increased formation of reactive oxygen species (ROS) and decreased antioxidant defense is defined as oxidative stress, which is widely recognized as an important feature of many diseases. Glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and catalase (CAT) are all cellular antioxidants, which protect cells from oxidative stress.…”