Recent progress in the understanding of psoriasis
has shown that the regulation of local and systemic cytokines
plays an important role in its pathogenesis. The most
often used psoriasis score is the psoriasis area and severity
index (PASI). A simple laboratory test from a blood sample would
be an attractive, patient-independent, and observer-independent
marker of disease severity. To this end, we evaluated the
association of serum levels of some proinflammatory cytokines
in vivo and their correlation with severity of psoriasis.
The serum levels of cytokines levels were determined with the use
of the ELISA method. All mean values except IL-17 levels of
patients were significantly higher than those of controls. There
was a significant correlation between serum levels of IFN-γ,
IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis
can be described as a T-cell-mediated disease, with a
complex role for a variety of cytokines, which has led to
the development of new immunomodulatory therapies. In this study,
serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18
levels were significantly higher in active psoriatic patients than
in controls. Furthermore, high levels of IFN-γ, IL-12, and
IL-18 correlated with the clinical severity and activity of
psoriasis, and those measurements of serum levels of these
cytokines may be objective parameters for the disease severity.
Dear Editor COVID-19 vaccination campaign in Turkey started with two-dose regimen of CoronaVac (Sinovac Life Sciences), a chemically inactivated whole virus vaccine (IVV), in January 2021. 1 It has been reported that humoral immune response to SARS-CoV-2 variants, such as 501Y.V2 (B.1.351), of the plasma and neutralizing antibodies elicited by CoronaVac suggest that a thirddose boost may be beneficial for combating SARS-CoV-2 variants when necessary. 2 Recent rapid spread of the Delta variant worldwide, and the fact that this variant has partially nullified vaccination 3 against SARS-CoV-2 forced many countries to consider application of additional vaccine doses.
We aimed to determine the effects of oxidative
stress in urinary tract infection (UTI). One hundred
sixty-four urine samples obtained from patients with the
prediagnosis of acute UTI admitted to the Faculty of
Medicine, Kahramanmaras Sutcu Imam University, were included in
this study. Urine cultures were performed according to standard
techniques. Urinary isolates were identified by using API ID 32E.
The catalase and superoxide dismutase activity and the lipid
peroxidation levels known as oxidative stress markers were
measured in all urine samples. Thirty-six pathogen microorganisms
were identified in positive urine cultures. These microorganisms
were as follows: 23 (63.8%) E coli, 5 (13.8%) P mirabilis, 4 (11.1%) K pneumoniae, 2 (5.5%)
Candida spp, 1 (2.7%) S saprophyticus, and 1
(2.7%) P aeruginosa. It was observed that lipid
peroxidation levels were increased while catalase and superoxide
dismutase activities were decreased in positive urine cultures,
compared to negative cultures. We conclude that urinary tract
infection causes oxidative stress, increases lipid peroxidation
level, and leads to insufficiency of antioxidant enzymes.
Intraperitoneal tenoxicam inhibited the formation of postoperative intra-abdominal adhesions without compromising wound healing in this bacterial peritonitis rat model. Tenoxicam also decreased the oxidative stress during peritonitis.
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