Recently problems in science education during the Covid-19 pandemic era are focusing on how to engage students in the online science classroom. There is a lack of exploration in learning experiences that engage students in virtual, thought-provoking problems, working with peers, and applying their 21 st -century skills as problem solver to real-world problems. One of the biggest challenges for secondary schools is that few guidelines or models exist regarding teaching science to engage students in the online classroom. Having this in mind, this study provided a systematic and analytical strategy in mapping out and offering a critical review of the integration of local wisdom of online science learning. Overall, this study recognized the gains that can be made from utilizing local wisdom in education, especially in the global quest of teaching 21st-century skills, and had recommended using local wisdom in instructional design. This paper also suggested a need to pursue further studies on developing a local wisdom framework for students easily master science learning media and how these could motivate and excite students and themselves in the teaching and learning process of the online science classroom.