The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus

Teixeira, Claudio Coimbra; Pinto, Luciana Ramos Corrêa; Kessler, Félix Henrique Paim; Knijnik, Lia; Pinto, Charles Budaszewski; Gastaldo, G.; Fuchs, Flávio Danni

doi:10.1016/s0378-8741(97)01532-8

Cited by 49 publications

(39 citation statements)

References 9 publications

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“…Nevertheless, investigations carried out in Brazil have shown that the leaves and the fruits of Syzygium cumini did not have effect on diabetes (Pepato et al, 2005;Teixeira et al, 1990;Teixeira et al, 1997;Teixeira et al, 2000). In this work there was no change in the seric concentration of glucose in animals treated for 30, 90 and 180 days with the Syzygium cumini HE (Tables 1, 2 extract-treated groups were significantly lower than the control group.…”

Section: Resultscontrasting

confidence: 44%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.

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Section: Resultscontrasting

confidence: 44%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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“…It was found, however, that S. jambos collected in southern Brazil and prepared by these methods did not affect the glycemia of normal individuals (5). Subsequent studies on normal and streptozotocindiabetic rats have also shown that aqueous extracts and decoctions of southern Brazilian E. jambolana have no hypoglycemic effects (2,23).…”

Section: Introductionmentioning

confidence: 98%

“…and Eugenia jambolana Lam. (synonym: Syzygium cumini (L.) skeels, sometimes called Syzygium jambolanum (2)(3)(4)(5)(6)), all of which have been cited as having physiological effects in various species, including man. For example, it has been reported that E. uniflora leaves have diuretic and anti-inflammatory effects (7), antihypertensive effects (3,8,9), antigout effects (7), and hypoglycemic and hypotriglyceridic effects (10).…”

Section: Introductionmentioning

confidence: 99%

“…The roots of E. punissifolia have been shown to have a hypoglycemic effect in normal and pancreatectomized dogs (4). In Brazil, both E. jambolana and Syzygium jambos are known by the common name Jambolão (2). The leaves of S. jambos have been reported to have a hypotensive action (11), and the leaves and flower buds of E. jambolana are considered diuretic (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Pepato

Folgado

Kettelhut

et al. 2001

Braz J Med Biol Res

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Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.

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“…Há estudos in vivo que comprovam o efeito hipoglicemiante do Jambolão, não somente em extratos alcoólicos e aquosos das sementes [34,35,36], como em extratos aquosos de folhas [37,38,39]. Estudos in vitro tem mostrado que o extrato metanólico de Jambolão é capaz de aumentar a expressão do transportador de glicose (GLUT-4), do receptor ativado por proliferadores de peroxissoma gama (PPARγ) e da fosfatidil-inositol 3-quinase (PI 3-quinase), resultando no aumento da captação de glicose pelas células musculares [40].…”

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Estudo etnobotânico de plantas medicinais utilizadas como hipoglicemiantes por usuários do Programa de Fitoterapia da Universidade Federal do Maranhão, Brasil

Santos

2017

Sci. Plena

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O uso de plantas medicinais no tratamento de enfermidades tem ocorrido há muitos anos, sendo a única terapia de certas comunidades. O Diabetes Mellitus é uma desordem metabólica caracterizada pela hiperglicemia, associada a outros fatores de risco. Este trabalho teve como finalidade realizar um levantamento de plantas medicinais utilizadas como hipoglicemiantes por usuários do Programa de Fitoterapia da Universidade Federal do Maranhão – UFMA, São Luís, Maranhão, Brasil. Foram entrevistadas 100 pessoas, através de questionários semiestruturados com obtenção de dados socioeconômicos e variáveis farmacobotânicas com listagem livre de plantas, aplicados entre os meses de março e junho de 2016. A maioria dos entrevistados era do sexo feminino (62%), com idade entre 30 e 59 anos (62%) e ensino médio completo (48%). Foram mencionadas 28 espécies vegetais com a finalidade hipoglicêmica, sendo a berinjela (Solanun melongena L.) a mais citada (31%). As folhas foram as partes da planta mais utilizadas (45%) e infusão foi a forma de preparo mais indicada pelos entrevistados (43%). O estudo das plantas realizado poderá auxiliar estudos posteriores no desenvolvimento de novos medicamentos para o tratamento de diabetes.

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The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus

Cited by 49 publications

References 9 publications

The toxicity evaluation of Syzygium cumini leaves in rodents

The toxicity evaluation of Syzygium cumini leaves in rodents

Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Estudo etnobotânico de plantas medicinais utilizadas como hipoglicemiantes por usuários do Programa de Fitoterapia da Universidade Federal do Maranhão, Brasil

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