The Effect of Systemic Tamsulosin Hydrochloride on Choroidal Thickness Measured by Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

Yolcu, Ümit; İlhan, Abdullah; Uzun, Salih

doi:10.3109/02713683.2015.1069854

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…All 3 observed points showed a significant thickness increase, and a vasomotor effect was suggested. In a comment to this paper, Yolcu et al [14] proposed that tamsulosin affinity to melanin leads to its choroidal sequestration and its α1A adrenoreceptor-blocking activity leads to CT increase. Dogan et al [13] in 2017 evaluated 63 right eyes of 63 patients diagnosed with BPH (32 taking alfuzosin and 31 tamsulosin) with EDI-OCT (ZEISS Cirrus HD-OCT 4000).…”

Section: Discussionmentioning

confidence: 96%

Choroidal evaluation in patients under alpha-lytic therapy

Bernardo

Altieri

Coppola

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To detect any choroidal thickness (CT) change in patients after alpha-lytic drugs withdrawal that could help in the cataract surgery timing decision. Methods Twenty-five eyes of 25 patients (mean age: 76 ± 7 years) under alpha-lytic therapy, and 25 eyes of 25 control subjects (CS) (mean age: 75 ± 7 years) without alpha-lytic therapy, both scheduled for cataract surgery in the fellow eye, were included in this observational, prospective, non-randomized study. All patients underwent EDI-OCT during the first preoperative visit and approximately 1 month (range 28-31 days) after alpha-lytic withdrawal. In the CS group, the OCT during preoperative visit and approximately 1 month after (range 28-31 days) the first examination was performed. Data normality with Kolmogorov-Smirnov test was checked and statistical evaluation with the Wilcoxon-signed rank test was performed.

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Section: Discussionmentioning

confidence: 96%

Choroidal evaluation in patients under alpha-lytic therapy

Bernardo

Altieri

Coppola

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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“…14 However, a randomized trial showed that neither oral alfuzosin nor oral tamsulosin were associated with significant change in CT from baseline at 1 and 3 months of use. 15 Vasodilation secondary to sympathetic adrenoceptors in the choroid 13 and affinity for tamsulosin for melanin in the choroid 90 were hypothesized causes for CT. Both of these hypotheses may need to be re-examined given the randomized trial's results.…”

Section: Alpha-1 Adrenoceptor Antagonistsmentioning

confidence: 99%

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

Yeung

Park

et al. 2022

Brit J Clinical Pharma

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The choroid plays an important role in various ocular pathologies and retinal blood supply. There is a knowledge gap on how the choroid is affected by systemic and topical medications. Systemic medications that affect microvasculature elsewhere in the body can also affect the microvasculature of the choroid. This review summarizes current knowledge on associations between systemic and topical medications and changes in choroidal thickness (CT). This review included 71 studies on mydriatics/cycloplegics, intraocular pressure (IOP)‐lowering therapies, antihypertensives, adrenergic antagonists, statins, corticosteroids, hydroxychloroquine, isotretinoin, hormonal contraceptives, phosphodiesterase inhibitors, antipsychotics, antineoplastic agents, ethanol, caffeine and nicotine. IOP‐lowering therapies, atropine eye drops, and systemic administration of β blockers and ethanol are associated with a significant increase in CT. Cyclopentolate and phenylephrine are associated with a CT reduction. Systemic medications that decrease CT include caffeine and nicotine. Tropicamide, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, statins, corticosteroids, hydroxychloroquine and hormonal contraceptives have mixed findings. CT increase associated with IOP‐lowering therapies is possibly achieved by enhancing aqueous humour flow to the choroid thus elevating choroidal blood flow and thickness. CT changes appear to be independent from systemic blood pressure changes, suggesting that a significant association with an antihypertensive could be due to an idiosyncratic drug property. Statins and candesartan decrease macrophage accumulation and intercellular adhesion molecule 1 expression in the choroid. The choroid and its response to various disease processes and systemic medication can be further investigated to improve patient care, particularly in patients with choroid and retina pathologies.

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The Effect of Systemic Tamsulosin Hydrochloride on Choroidal Thickness Measured by Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

Cited by 2 publications

References 2 publications

Choroidal evaluation in patients under alpha-lytic therapy

Choroidal evaluation in patients under alpha-lytic therapy

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

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