The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model

Ercan, Umut; Kiraz, Aslı Öztürk; Çıkman, Öztekin; Türkön, Hakan; Kılınç, Nihal; Otkun, Metin; Özkan, Ömer Faruk; Kiraz, Hasan Ali; Karaayvaz, Muammer

doi:10.3109/08941939.2015.1029652

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In our study, we examined the effects of L-carnitine, which is an antioxidant molecule, on injury healing in early and late period. It was already shown that L-carnitine application has positive effects on colon anastomosis healing [35]. Caecal ligation, formation of peritonitis by drilling, and colon anastomosis were made simultaneously in the mentioned study.…”

Section: Kandas Et Almentioning

confidence: 88%

Healing effects of L-carnitine on experimental colon anastomosis wound

Kandaş

Edremitlioğlu

Demir

et al. 2023

Marmara Medical Journal

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Objective: The purpose of this study is to examine the effects of L-carnitine on healing of experimental colon anastomosis injury in early and late period. Materials and Methods: Forty female Wistar-Albino rats were used in this study. The rats were divided into 4 groups (CONT-3, CONT- 7, CARN-3, and CARN-7). Injury healing was evaluated for CONT-3 group on the 3rd day and for CONT-7 group on the 7th day following the anastomosis. Following the operation, CARN-3 and CARN-7 groups were intraperitoneally administered with 100 mg/ kg/day L-carnitine and injury healing was evaluated on the 3rd and 7th days. Injury strength, histological evaluation and antioxidant enzyme activities and oxidant damage were determined in tissue samples of anastomosis area. Results: Bursting pressure levels and histological scoring values of CARN-3 group were found to be higher than the CONT-3 group (p

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Section: Kandas Et Almentioning

confidence: 88%

Healing effects of L-carnitine on experimental colon anastomosis wound

Kandaş

Edremitlioğlu

Demir

et al. 2023

Marmara Medical Journal

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“…The animal studies of CARN-or acetyl-CARN-induced protection against proinflammatory conditions were focused on the same set of test-induced noxae (steatohepatitis, peritonitis, neuroinflammation) [92][93][94][95], as shown in Table 2. The results showed that (acetyl-)CARN decreased the levels of several proinflammatory endpoints, including proinflammatory markers, NF-ĸB and IL-1 and IL-6, and ameliorated organ inflammation [96,97].…”

Section: Mitochondrial Nutrients: Action Mechanisms and Antioxidant Pmentioning

confidence: 99%

Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia

et al. 2020

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Background The mitochondrial cofactors α-lipoic acid (ALA), coenzyme Q10 (CoQ10) and carnitine (CARN) play distinct and complementary roles in mitochondrial functioning, along with strong antioxidant actions. Also termed mitochondrial nutrients (MNs), these cofactors have demonstrated specific protective actions in a number of chronic disorders, as assessed in a well-established body of literature. Methods Using PubMed, the authors searched for articles containing information on the utilization of MNs in inflammatory disorders as assessed from in vitro and animal studies, and in clinical trials, in terms of exerting anti-inflammatory actions. Results The retrieved literature provided evidence relating acute pathologic conditions, such as sepsis and pneumonia, with a number of redox endpoints of biological and clinical relevance. Among these findings, both ALA and CARN were effective in counteracting inflammation-associated redox biomarkers, while CoQ10 showed decreased levels in proinflammatory conditions. MN-associated antioxidant actions were applied in a number of acute disorders, mostly using one MN. The body of literature assessing the safety and the complementary roles of MNs taken together suggests an adjuvant role of MN combinations in counteracting oxidative stress in sepsis and other acute disorders, including COVID-19-associated pneumonia. Conclusions The present state of art in the use of individual MNs in acute disorders suggests planning adjuvant therapy trials utilizing MN combinations aimed at counteracting proinflammatory conditions, as in the case of pneumonia and the COVID-19 pandemic.

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“…It has known effects on ROS inhibition, in situations as preventing muscle loss in sepsis,. In this sense, Ercan et al [28] performed colonic anastomosis and daily administered carnitine intraperitoneally in sepsis models in rats until the 5th post-op day. The results found that carnitine has protective effects on anastomosis, even in conditions that affect the healing process, such as sepsis.…”

Section: Melatoninmentioning

confidence: 99%

Use of Antioxidant Substances in Intestinal Anastomosis in Rats

Carneiro

Yasojima²,

Costa³

et al. 2019

int arch med

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Introduction: Intestinal anastomosis consist of surgical procedures which there is an anastomotic line between two intestinal segments in order to reconstruct or divert the digestive transit. However, several complications may result from this surgical procedure. Objective: Present, describe and discuss the findings of the literature regarding substances capable of reducing injury and possible complications of intestinal anastomoses. Method: The data were collected by literature review using the descriptors: "intestinal anastomoses", "antioxidants"; and as basis articles published in the published Scientific Electronic Library (Scielo), Lilacs, MedLine and Pubmed databases. Inclusion criteria were original and review articles published in full in the online form in the Portuguese, Spanish and English languages, using the descriptors mentioned above in the respective languages. Results: Scientific articles were collected, in which 38 papers were included in the inclusion criteria. Conclusions: The major parts of substances described in the present study demonstrated be statistically relevant results and the capacity to optimize the anastomotic healing.

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The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model

Cited by 5 publications

References 28 publications

Healing effects of L-carnitine on experimental colon anastomosis wound

Healing effects of L-carnitine on experimental colon anastomosis wound

Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia

Use of Antioxidant Substances in Intestinal Anastomosis in Rats

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