The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2–5 Years

Aflatoonian, Majid; Ardakani, Abbas Taghavi; Modarresi, Seyedeh Zalfa; Modaresi, Vajiheh; Karimi, Mehran; Ordooei, Mahtab; Vakili, Mahmood; Pakseresht, Bahar

doi:10.1007/s12602-018-9508-6

Cited by 7 publications

(15 citation statements)

References 44 publications

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“…The studies were undertaken in various countries, 3 studies (37.5%) were carried out in Iran (23,24,26), 1 (12.5%) in Indonesia (22), and 1 (12.5%) in each of Pakistan (27), Bangladesh (28), India (21), and China(25) (fig 3: Geographical distribution of included articles: Supplementary file). Five (62.5%) studies were carried out on healthy children (21)(22)(23)(24)(25) and three (37.5%) on malnourished children (26)(27)(28). Three studies (37.5%) evaluated a synbiotic (21,23,26), two (25%) prebiotics (24,27), and one (12.5%) probiotics (22).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Five (62.5%) studies were carried out on healthy children (21)(22)(23)(24)(25) and three (37.5%) on malnourished children (26)(27)(28). Three studies (37.5%) evaluated a synbiotic (21,23,26), two (25%) prebiotics (24,27), and one (12.5%) probiotics (22). One (12.5%), probiotic and synbiotic (28) and one (12.5%) evaluated both prebiotics and synbiotic (25).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis

Khouma,

Diallo,

Sow

et al. 2024

Preprint

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Background Poor growth is one of the major obstacles to human development, affecting millions of children under the age of 5 years, particularly those living in low- and middle-income countries. The objective of this review was to evaluate the efficacy of administering pre-, pro- or synbiotics on the growth of children aged 0–59 months living in LMICs. Methods Google scholar, Pubmed, clinical trial.org and Science Direct databases were searched in April 2023 for randomised controlled trials of pre-, pro- or synbiotics that evaluated growth in under fives in LMICs. The primary outcome were weight and height gain. Secondary outcomes were head circumference, body mass index gain and Z score. Random-effects meta-analysis was used to calculate mean differences for continuous outcomes. Grading of Recommendations Assessment, Development and Evaluation criteria was used to assess certainty of the evidence. Results Eight trials involving 1375 children under 5 years of age were identified. Meta-analysis of 6 RCTs (n = 991 children) revealed a significant difference in favor of the experimental group (n = 579) compared the control group (n = 412) for weight gain: (MD = 0.33 kg, 95% CI 0.11 to 0.55); low-certainty evidence. Sub-group analysis revealed that, pre-, pro, or synbiotics may be more effective in malnourished that healthy children (p = 0.003). Meta-analysis of height gain for 4 RCTs (n = 845) found that there was no significant difference between the experimental group (n = 496) and the control group (n = 349) (MD = 0.31 cm; 95% CI -0.36 to 0.98); low-certainty evidence. In sub-group analysis, prebiotics had a greater impact on height gain than synbiotics (p = 0.03). In the only study reporting an increase in head circumference (n = 32 children), this was not improved by the administration of synbiotics. However, administration of synbiotics to undernourished children significantly improved BMI gain. Conclusion The evidence for the administration of pre-, pro- or synbiotics on the growth of children in LMICs is weak. Administration of pre-, pro- or synbiotics may improve weight gain and synbiotics may improve BMI, particularly in malnourished children. Further research is needed due to the small number of studies, short duration of administration and small sample size.

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis

Khouma,

Diallo,

Sow

et al. 2024

Preprint

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“…One trial reported data on BMI among 69 children, of which 37 received probiotics and 32 received the comparator (22). The evidence was very uncertain about the effect of probiotics on BMI in undernourished children versus the comparator (SMD 0.25 SD, 95%: CI −0.23 to 0.72; P = 0.31; Figure S3B, Supplemental Digital Content 6, http://links.lww.com/MPG/D334).…”

Section: Body Mass Indexmentioning

confidence: 99%

“…The title and abstract screening yielded 214 full-text records, of which 205 were excluded using predetermined eligibility criteria. Thus, 9 trials were included in the systematic review (22)(23)(24)(25)(26)(27)(28)(29)(30), of which 9 were included in the meta-analysis (22)(23)(24)(25)(26)(27)(28)(29). A PRISMA flow diagram of our study selection process is depicted in Figure 1 (14).…”

Section: Literature Searchmentioning

confidence: 99%

“…Seven trials reported data on weight-for-age among 1357 children, of which 682 received probiotics and 675 received the comparator (22)(23)(24)(25)(26)28,29). The combined results showed low-certainty evidence that probiotics may have little to no effect on weight-forage in undernourished children versus the comparator (SMD 0.05 SD, 95% CI: −0.04 to 0.13; P = 0.29; Fig.…”

Section: Weight-for-agementioning

confidence: 99%

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Probiotic Supplementation for Promotion of Growth in Undernourished Children: A Systematic Review and Meta-Analysis

Imdad,

Pandit,

Ehrlich

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Probiotic supplementation has been proposed as a therapeutic intervention to improve growth outcomes in children with undernutrition. The objective of this review to synthesize the current evidence on probiotic supplementation for promotion of growth in undernourished children. Methods: We searched MEDLINE, Cochrane CENTRAL, CINAHL, Embase, LILACS, and Scopus for randomized controlled trials (RCTs) that administered probiotics or eligible comparators to undernourished children below 5 years of age. Our primary outcomes of interest were weight-for-age, height-for-age, and weight-for-height at the longest follow-up points reported. Random-effects meta-analysis was used to calculate standardized mean differences (SMD) for continuous outcomes and risk ratios (RR) for dichotomous outcomes. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria were used to assess certainty of the evidence. Results: Nine RCTs with 5,295 children in total were included. Durations of treatment ranged from 1 month to 1 year. Pooled analyses from seven studies showed that probiotics may have little to no effect on weight-for-age (SMD 0.05 standard deviation [SD], 95% CI −0.04 to 0.13, n = 2115 children; low-certainty evidence) and height-for-age (SMD −0.04 SD, 95% CI −0.14 to 0.07, n = 1357 children; low-certainty evidence). The evidence was very uncertain about the effect on weight-for-height. Conclusions: Probiotics may have little to no effect on anthropometry in undernourished children, though there is considerable heterogeneity among the trials reviewed thus far. The interaction between gut microbiota and human nutrition is complex, and further research is needed to determine how the gut microbiome may contribute to undernutrition and how probiotics may affect growth in this vulnerable population.

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Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

Zoghi,

Sadeghpour Heravi,

Nikniaz

et al. 2023

Engineering in Life Sciences

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Childhood malnutrition is a metabolic condition that affects the physical and mental well‐being of children and leads to resultant disorders in maturity. The development of childhood malnutrition is influenced by a number of physiological and environmental factors including metabolic stress, infections, diet, genetic variables, and gut microbiota. The imbalanced gut microbiota is one of the main environmental risk factors that significantly influence host physiology and childhood malnutrition progression. In this review, we have evaluated the gut microbiota association with undernutrition and overnutrition in children, and then the quantitative and qualitative significance of gut dysbiosis in order to reveal the impact of gut microbiota modification using probiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, and engineering biology methods as new therapeutic challenges in the management of disturbed energy homeostasis. Understanding the host–microbiota interaction and the remote regulation of other organs and pathways by gut microbiota can improve the effectiveness of new therapeutic approaches and mitigate the negative consequences of childhood malnutrition.

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The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2–5 Years

Cited by 7 publications

References 44 publications

Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis

Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis

Probiotic Supplementation for Promotion of Growth in Undernourished Children: A Systematic Review and Meta-Analysis

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

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