The effect of surgical approach on the outcomes and prognosis of high-risk histologic endometrioid carcinomas

Han, Zhi-hong; Zheng, Zhong; Tao, Kai; Yu, Yanping; Jinping, WU; Tian, Xuemei

doi:10.21037/gs-20-887

Cited by 4 publications

(6 citation statements)

References 27 publications

(31 reference statements)

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“…24 Other similar retrospective studies also reported that MIS appears to be feasible and safe for highrisk endometrial cancer. [25][26][27] Our study finds that laparoscopic surgery is oncologically safe for patients with apparent early-stage USC. Compared with endometrioid endometrial cancer, patients with non-endometrioid endometrial cancer are usually older, which also means that the USC population usually has more comorbidities.…”

Section: Discussionmentioning

confidence: 56%

“…In a multi‐institutional retrospective cohort study, 383 women with high‐risk endometrial cancer were included, of which 192 patients underwent minimally invasive surgical staging, no statistically significant difference was observed in progression‐free survival (MIS vs. open surgery, HR 1.05, 95% CI 0.96–1.19, P = 0.451) and 3‐year OS (MIS vs. open surgery, 85.5% vs. 84.1%, P = 0.725) between the minimally invasive surgery group and the open surgery group after a median follow‐up time of 44 months 24 . Other similar retrospective studies also reported that MIS appears to be feasible and safe for high‐risk endometrial cancer 25–27 …”

Section: Discussionmentioning

confidence: 99%

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Oncologic safety of laparoscopic surgery for women with apparent early‐stage uterine serous carcinoma: A multi‐institutional retrospective cohort study

Shen

Zhang

et al. 2021

Intl J Gynecology & Obste

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Cancer of the endometrium is the most common malignancy of the female reproductive system in developed countries, its incidence and associated mortality are increasing because rates of obesity have risen. [1][2][3] Two broad histologic types of endometrial cancer were proposed by Bokhman in 1983. 4 Type I tumors, affecting about 80% of cases, are mediated primarily by hyperestrogenism and are generally associated with a good prognosis. 2,5 Type II endometrial cancers, in contrast, have no exact pathogenesis. 2,5 Histologically, type II tumors are poorly differentiated or undifferentiated, most commonly serous and clear cell subtypes. 6 They are clinically aggressive, usually present at advanced stages, are associated with poor prognosis, and have a higher risk of recurrence. 6,7 Uterine serous carcinoma (USC) is the most common histologic type of type II endometrial cancer, accounting for about 80% of non-endometrioid endometrial cancer and approximately 40% of all endometrial cancer-related mortality. 8

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Oncologic safety of laparoscopic surgery for women with apparent early‐stage uterine serous carcinoma: A multi‐institutional retrospective cohort study

Shen

Zhang

et al. 2021

Intl J Gynecology & Obste

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“…Overall, 3 studies were identified that reported survival outcomes of patients with type II (high grade) endometrial carcinoma subtypes [16][17][18]. One of those was specifically focused on survival rates of CC endometrial carcinoma patients [17].…”

Section: Resultsmentioning

confidence: 99%

“…Lastly, Han, et al evaluated the impact of surgical approach on survival outcomes of high-risk endometrial carcinomas and observed that the laparoscopic route significantly decreased survival rates of patients with type II endometrial carcinoma [18]. However, subgroup analysis according to the type of cancer did not significantly affected survival outcomes; although uterine clear cell carcinoma was associated with shorter survival rates compared to poorly differentiated adenocarcinoma in the whole series.…”

Section: Resultsmentioning

confidence: 99%

Is it Reasonable to Suggest the use of Laparoscopic Surgery for Endometrial Cancer Patients with Clear Cell Histology?

Vasilios¹,

Eleftherios²,

Vasilis³

et al. 2022

2689-8764

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Clear cell endometrial carcinoma comprises an aggressive subtype of endometrial cancer that is associated with poor survival outcomes compared to endometrioid carcinoma. Laparoscopic surgery became the standard of care treatment of early-stage endometrial cancer during the last decade; however, its impact on survival outcomes of patients with clear cell carcinoma has not been fully elucidated. In the present systematic review, we analyzed the available evidence published in Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar. Three studies were retrieved that were substantially heterogeneous; hence, meta-analysis was precluded. Current evidence suggests that minimally invasive surgery does not significantly affect progression free and overall survival rates compared to standard laparotomy; however, given the relative paucity of data further studies are needed prior to ascertaining the safety of the technique.

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“…Overall, 3 studies were identified that reported survival outcomes of patients with type II (high grade) endometrial carcinoma subtypes. [16][17][18] One of those was specifically focused on survival rates of CC endometrial carcinoma patients. 17 The methodological quality of included studies was evaluated as high following estimation of the potential risk of bias with the Newcastle Ottawa tool.…”

Section: Resultsmentioning

confidence: 99%

Laparoscopic surgery for clear cell endometrial carcinoma, is it a realistic approach?

Zachariou¹,

Pergialiotis²,

Iliopoulos³

et al. 2022

HJOG

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Clear cell endometrial carcinoma is an aggressive form of endometrial cancer that has a poor prognosis for survival. Over the past ten years, laparoscopic surgery has replaced open surgery as the preferred method of treating early-stage endometrial cancer. However, its effect on the prognosis of patients with clear cell carcinoma is still unclear. In the current systematic review, we examined the information that was published in the following databases: Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials, CENTRAL, and Google Scholar. Three studies were found to be significantly diverse; as a result, meta-analysis was not possible. Current research reveals that compared to traditional laparotomy, minimally invasive surgery does not significantly influence progression-free and overall survival rates; nevertheless, given the relative dearth of data, more research is required before the technique’s safety can be determined.

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The effect of surgical approach on the outcomes and prognosis of high-risk histologic endometrioid carcinomas

Cited by 4 publications

References 27 publications

Oncologic safety of laparoscopic surgery for women with apparent early‐stage uterine serous carcinoma: A multi‐institutional retrospective cohort study

Oncologic safety of laparoscopic surgery for women with apparent early‐stage uterine serous carcinoma: A multi‐institutional retrospective cohort study

Is it Reasonable to Suggest the use of Laparoscopic Surgery for Endometrial Cancer Patients with Clear Cell Histology?

Laparoscopic surgery for clear cell endometrial carcinoma, is it a realistic approach?

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