Clear cell endometrial carcinoma comprises an aggressive subtype of endometrial cancer that is associated with poor survival outcomes compared to endometrioid carcinoma. Laparoscopic surgery became the standard of care treatment of early-stage endometrial cancer during the last decade; however, its impact on survival outcomes of patients with clear cell carcinoma has not been fully elucidated. In the present systematic review, we analyzed the available evidence published in Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar. Three studies were retrieved that were substantially heterogeneous; hence, meta-analysis was precluded. Current evidence suggests that minimally invasive surgery does not significantly affect progression free and overall survival rates compared to standard laparotomy; however, given the relative paucity of data further studies are needed prior to ascertaining the safety of the technique.
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