The Effect of Surfactant on the Dissolution of Porcine Pulpal Tissue by Sodium Hypochlorite Solutions

Clarkson, Roger M.; Kidd, Bruce; Evans, Gareth E.; Moule, Alex J.

doi:10.1016/j.joen.2012.05.013

Cited by 38 publications

(37 citation statements)

References 29 publications

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“…The average dissolution time was 36 min with a speed of 0.18 mg/min, similar to NaOCl alone. These results agree with the findings of Clarkson et al (8) and De-Deus et al (23), which did not observe faster dissolution when combining NaOCl with a surfactant. It is important to notice that the rate used in this study was 1:1 diluted NaOCl and different rates deserve to be further investigated.…”

Section: Pulp Tissue Dissolutionsupporting

confidence: 93%

“…Some studies report increased tissue dissolution with the combination of NaOCl and a surfactant agent (3,7). However, other studies have not shown this advantage (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…It has been used in combination with various irrigating solutions (NaOCl, chlorhexidine, EDTA, etc.) to reduce surface tension and increase the penetration in the root canal system (8,11).…”

Section: Introductionmentioning

confidence: 99%

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Bovine Pulp Tissue Dissolution Ability of Irrigants Associated or Not to Ultrasonic Agitation

et al. 2015

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The aim of this study was to evaluate the tissue dissolution ability of different irrigating solutions associated or not to ultrasonic agitation. Ninety bovine pulp fragments (n=10 per group) were weighed and then placed individually in Eppendorf test tubes containing the following irrigants: G1-2.5% sodium hypochlorite (NaOCl); G2-2.5% NaOCl + ultrasonic agitation (US); G3-2.5% NaOCl + 0.2% cetrimide (CTR); G4-2.5% NaOCl + 0.2% CTR + US; G5-400 ppm Sterilox (SX); G6-SX + US; G7-0.2% CTR; G8-0.2% CTR + US; G9-saline solution. Two blinded observers assessed the samples continuously for the first 4 h, and then every hour for the next 12 h. Dissolution speed was calculated by dividing the initial pulp weight (mg) by the period of time until complete dissolution (min). Data were compared by ANOVA and Tukey post hoc test with a 5% significance level. G1 to G4 dissolved pulp fragments completely and G2 was significantly faster than the other groups. G5 to G9 did not exhibit dissolving activity. In conclusion, only groups containing NaOCl were capable of pulp tissue dissolution, which was enhanced by ultrasonic agitation, but did not alter when 0.2% cetrimide was associated. This isolated solution and Sterilox showed no dissolving capacity, regardless the use of ultrasound.

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Section: Pulp Tissue Dissolutionsupporting

confidence: 93%

“…Some studies report increased tissue dissolution with the combination of NaOCl and a surfactant agent (3,7). However, other studies have not shown this advantage (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Bovine Pulp Tissue Dissolution Ability of Irrigants Associated or Not to Ultrasonic Agitation

et al. 2015

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“…A subsequent investigation appeared to eliminate the presence or absence of surfactant content of Hypochlor as the cause of these differences. 14 Overall, the relationship between the ability of various solutions of NaOCl to dissolve tissue and their residual active chlorine content has not been established. One early study did demonstrate that using NaOCl to dissolve a protein hydrolysate caused rapid loss of active chlorine content in the solution.…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study, it exhibited a poor ability to dissolve pig pulp tissue not explained by differences in nominal active chlorine content. 13,14 If exhaustion of the active chlorine was the reason for poor pulp dissolution, Milton would be more likely to exhibit this phenomenon than other NaOCl solutions. If there was little loss of residual active chlorine in Milton, then it would be even less likely this would occur in other NaOCl solutions.…”

Section: Introductionmentioning

confidence: 99%

Assessment of residual active chlorine in sodium hypochlorite solutions after dissolution of porcine incisor pulpal tissue

Clarkson¹,

Smith²,

Kidd³

et al. 2013

Aust Dent J

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Background: In previous studies, surfactant-containing Hypochlor brands of sodium hypochlorite showed better tissue solubilizing abilities than Milton; differences not explained by original active chlorine content or presence of surfactant. It was postulated that exhaustion of active chlorine content could explain differences. This study aimed to assess whether Milton's poorer performance was due to exhaustion of active chlorine. Parallel experiments assessed the influence of titration methods, and the presence of chlorates, on active chlorine measurements. Methods: Time required to dissolve one or groups of 10 samples of porcine incisor pulp samples in Milton was determined. Residual active chlorine was assessed by thermometric titration. Iodometric and thermometric titration was carried out on samples of Milton. Chlorate content was also measured. Results: Dissolution of single and 10 pulp samples caused a mean loss of 1% and 3% respectively of active chlorine, not being proportional to tissue dissolved. Thermometric ammonium ion titration resulted in 10% lower values than iodometric titration. Chlorate accounted for much of this difference. Conclusions: Depletion of active chlorine is not the reason for differences in tissue dissolving capabilities of Milton. Thermometric ammonium ion titration gives more accurate measurement of active chlorine content than iodometric titration.

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Irrigating Solutions, Devices, and Techniques

Boutsioukis

Arias-Moliz

2021

Endodontic Materials in Clinical Practice

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The Effect of Surfactant on the Dissolution of Porcine Pulpal Tissue by Sodium Hypochlorite Solutions

Cited by 38 publications

References 29 publications

Bovine Pulp Tissue Dissolution Ability of Irrigants Associated or Not to Ultrasonic Agitation

Bovine Pulp Tissue Dissolution Ability of Irrigants Associated or Not to Ultrasonic Agitation

Assessment of residual active chlorine in sodium hypochlorite solutions after dissolution of porcine incisor pulpal tissue

Irrigating Solutions, Devices, and Techniques

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