The effect of sub-chronic nandrolone decanoate treatment on dopaminergic and serotonergic neuronal systems in the brains of rats

Kurling, Sanna; Kankaanpää, Aino; Ellermaa, Satu; Karila, Tuomo; Seppαlä, Timo

doi:10.1016/j.brainres.2005.02.071

Cited by 39 publications

(21 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In AH, 5HT1A receptors are also reduced [142], while 5HT1B receptors are down-regulated in the medial globus pallidus and the CA1 region of hippocampus [94]. By contrast, AAS increase serotonin levels in cerebral cortex [99], and 5HT2 receptors in Acb [94]. In male volunteers receiving injections of methyltestosterone, levels of the serotonin metabolite 5-hydroxyindolacetic acid in cerebrospinal fluid increased, and this was correlated with activation symptoms: energy, sexual arousal, diminished sleep [42].…”

Section: Serotoninmentioning

confidence: 98%

“…Nonetheless, the specific mechanisms through which AAS and DA interact are still unclear. Thiblin et al [171] observed an increase in DA synthesis in response to methandrostenolone, and nandrolone stimulates the DA metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in cerebral cortex [99]. On the other hand, as measured by in vivo microdialysis with HPLC, testosterone does not appear either to stimulate Acb DA release [177], or to potentiate amphetamine-stimulated DA in Acb [13].…”

Section: Dopaminementioning

confidence: 99%

See 1 more Smart Citation

Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

View full text Add to dashboard Cite

Anabolic-androgenic steroids (AAS) are drugs of abuse. They are taken in large quantities by athletes and others to increase performance, with negative health consequences. As a result, in 1991 testosterone and related AAS were declared controlled substances. However, the relative abuse and dependence liability of AAS have not been fully characterized. In humans, it is difficult to separate the direct psychoactive effects of AAS from reinforcement due to their systemic anabolic effects. However, using conditioned place preference and self-administration, studies in animals have demonstrated that AAS are reinforcing in a context where athletic performance is irrelevant. Furthermore, AAS share brain sites of action and neurotransmitter systems in common with other drugs of abuse. In particular, recent evidence links AAS with opioids. In humans, AAS abuse is associated with prescription opioid use. In animals, AAS overdose produces symptoms resembling opioid overdose, and AAS modify the activity of the endogenous opioid system. KeywordsAnabolic agents; Testosterone; self-administration; hamsters; drug dependence • Breakfast of champions: Recent history and prevalence of AAS useAnabolic-androgenic steroids (AAS) are a hot topic. A search of the Google news archive in March 2007 reveals 47,500 news stories on "steroids" in 2006, a 400% increase since their debut in the archive in 2002. In 2006, "steroids" even surpassed trend-setters such as "Paris Hilton" (38,500 stories) or "spinach" (42,700 stories). Current media attention on AAS abuse has been driven by accusations of steroid use among professional athletes in baseball, track, and cycling. However, public recognition of AAS use in sports dates back nearly 20 years, when Ben Johnson tested positive for stanozolol at the Seoul Olympics in 1988 [77]. Eastern Block athletes had been using steroids since the 1950's, and the International Olympic Committee banned steroid use from Olympic competition in 1976. However, the ability to reliably detect androgen metabolites in urine samples was limited until the advent of gas chromatography-mass spectroscopy [89]. Johnson's drug test spurred the United States Congress to pass the Anabolic Steroid Control Act of 1991 which declared steroids as Address all reprint requests and correspondence to Ruth I. Wood, Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo St., BMT 401, Los Angeles, CA 90033. Telephone (323) 442-1980, Fax: (323) 442-3466, e-mail: riw@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain....

show abstract

Section: Serotoninmentioning

confidence: 98%

Section: Dopaminementioning

confidence: 99%

Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

View full text Add to dashboard Cite

show abstract

“…Na série vermelha, os valores não tiveram variação significativa entre os diferentes grupos. Entretanto, KURLING et al (2005), estudando o DN em ratos sadios nas doses de 5 e 20mg kg -1 com uma injeção diária por cinco dias na semana, durante duas semanas, observaram um aumento significativo no último dia de tratamento (17 o dia), nos eritrócitos totais e na hemoglobina somente nos animais que receberam 5mg kg -1 . Dessa forma, as doses utilizadas em G5 e G6 podem não ter estimulado a linhagem eritrocítica devido ao número e/ou intervalo de tempo em que as injeções foram aplicadas, pois a resposta ao tratamento de estimulação hematopoética é dependente de sua duração, ou ainda, do número de CT viáveis na MO (FELDMAN et al, 2000).…”

Section: Resultsunclassified

“…Parte da literatura consultada cita a presença de estimulação medular com doses inferiores às utilizadas no trabalho, porém com intervalos de tempos diários (SAITOH et al, 1999;KURLING et al, 2005). Contudo, outros autores comentam o uso semanal do DN, com dosagens inferiores ou não as utilizadas no presente estudo (BARTON et al, 2002;NELSON & COUTO, 2006).…”

Section: Resultsunclassified

Decanoato de nandrolona no hemograma e nas células mononucleares da medula óssea de ratos Wistar hígidos

et al. 2010

View full text Add to dashboard Cite

show abstract

“…AAS reduce the expression of serotonin receptors in the anterior hypothalamus (1A), globus pallidus (1B) or hippocampus [23,24]. They decrease serotonin concentration in basal forebrain and dorsal striatum [25], but increase in the cerebral cortex [26]. AAS are also likely to influence the brain GABA system and modify the mesolimbic dopamine system by stimulation of dopamine release and synthesis [26].…”

Section: Discussionmentioning

confidence: 99%

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

L¹

2013

J Steroids Horm Sci

View full text Add to dashboard Cite

Objective: Androgenic-anabolic steroids (AAS) are commonly used by athletes and recreational athletes. In some cases they induce persistent anabolic steroid-induced hypogonadism (ASIH). Design:In an observational study we assessed the function of the pituitary-gonadal axis in a series of men with suspected ASIH. Methods:Clomiphene stimulation test (CST) was performed in 13 hypogonadal adult men with previous, prolonged exposure to AAS. We evaluated the response of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T) to 50 mg of clomiphene daily administered for a week.Results: Mean concentrations of hormones before and after clomiphene administration were respectively (mean ± SD): 3 ± 1.2 and 8.3 ± 2 mIU/ml for LH; 3 ± 1.1 and 10 ± 14.6 mIU/ml for FSH; and 2.3 ± 0.6 and 7.2 ± 1.7 ng/ml for T (p<0.001). Conclusions:Men with ASIH, after a long-time withdrawal of AAS, present an intact reaction of gonadotropins and testosterone to clomiphene stimulation.

show abstract

The effect of sub-chronic nandrolone decanoate treatment on dopaminergic and serotonergic neuronal systems in the brains of rats

Cited by 39 publications

References 64 publications

Anabolic–androgenic steroid dependence? Insights from animals and humans

Anabolic–androgenic steroid dependence? Insights from animals and humans

Decanoato de nandrolona no hemograma e nas células mononucleares da medula óssea de ratos Wistar hígidos

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

Contact Info

Product

Resources

About