The effect of strict rate control on B-type natriuretic peptide values and echocardiographic parameters in chronic atrial fibrillation

Özkurt, Yalçın; Özpelit, Ebru; Aslan, Özgür; Göldeli, Özhan

doi:10.5603/kp.a2014.0092

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…It is postulated that an increased ventricular rate during AF leads to the oxygen mismatch, myocardial ischaemia, volume and pressure overload, and changes in microvascular blood flow, thus resulting in the ventricular production of natriuretic peptides [10]. It was also demonstrated that strict rate control yielded a prominent decrease in BNP values in AF patients [11]. Atrial peptide secretion has received less attention.…”

Section: Discussionmentioning

confidence: 99%

The intracardiac concentrations of the N-terminal-pro B-type natriuretic peptide (NT-proBNP) and the determinants of its secretion in patients with atrial fibrillation

Streb¹,

Mitręga²,

Szymała³

et al. 2018

Kardiol Pol

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A b s t r a c tBackground: N-terminal-pro B-type natriuretic peptide (NT-proBNP) is elevated not only in heart failure (HF) but also in atrial fibrillation (AF). The role and secretion pattern of NT-proBNP in AF is still undetermined. Aim:The study aimed to assess NT-proBNP concentrations in patients with and without preserved left ventricular ejection fraction (LVEF) depending on the type of AF. It was also intended to define the main source of NT-proBNP production within the heart. In addition, it aimed to study the relation of NT-proBNP with some echocardiographic parameters reflecting the stretch of heart chambers as well as with the chosen parameters of physical capacity.Methods: Blood samples were collected from the right atrium (RA), left atrium (LA), and femoral artery (FA) in 53 patients referred for occlusion of the LA appendage. Thirty patients were assigned into Group I (LVEF ≥ 50%, no HF symptoms) and the remaining 23 patients to Group II (LVEF < 50%, HF symptoms). NT-proBNP concentrations were determined using the ELISA test. Results:In Group I, the lowest NT-proBNP level was found in RA (460.47 ± 723.15 pg/mL and 1097.72 ± 851.42 pg/mL for paroxysmal and permanent AF, respectively), higher in LA (481.5 ± 724.56 pg/mL and 1188.06 ± 851.42 pg/mL for paroxysmal and permanent AF), and the highest values in FA (537.77 ± 808.49 pg/mL and 1188.04 ± 798.28 pg/mL for paroxysmal and permanent AF). In Group II the NT-proBNP values were significantly higher compared to Group I (p < 0.01), but similarly values in RA were the lowest (183.47 ± 1826.08 pg/mL and 2141.68 ± 1801.69 pg/mL for paroxysmal and permanent AF), intermediate values were observed in LA (1857.57 ± 2221.39 pg/mL and 2386.81 ± 2067.2 pg/mL for paroxysmal and permanent AF), and the highest were seen in FA (1936FA ( .27 ± 2149FA ( .85 and 2437FA ( .33 ± 1999.37 pg/mL for paroxysmal and permanent AF, respectively). In Group I, NT-proBNP from LA best correlated with LA area (r = 0.56) and RA area (r = 0.56). In Group II, the strongest correlations were found between NT-proBNP from LA and left ventricular end-systolic dimension (r = 0.57) and volume (r = 0.6). Conclusions:NT-proBNP is markedly elevated in the majority of patients with AF even in the absence of HF. LA secretion of NT-proBNP is an important contributor to the overall increase of NT-proBNP also in HF patients. In AF patients, the concentration of NT-proBNP correlates with the remodelling of heart chambers, but not with physical capacity.

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Section: Discussionmentioning

confidence: 99%

The intracardiac concentrations of the N-terminal-pro B-type natriuretic peptide (NT-proBNP) and the determinants of its secretion in patients with atrial fibrillation

Streb¹,

Mitręga²,

Szymała³

et al. 2018

Kardiol Pol

View full text Add to dashboard Cite

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Is 10-second electrocardiogram recording enough for accurately estimating heart rate in atrial fibrillation

Shuai¹,

Wang²,

Hong

et al. 2016

International Journal of Cardiology

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How to estimate heart rate from pulse rate reported by oscillometric method in atrial fibrillation: The value of pulse rate variation

Shuai

Wang

Hong

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

The effect of strict rate control on B-type natriuretic peptide values and echocardiographic parameters in chronic atrial fibrillation

Abstract: Strict rate control in patients with chronic AF yielded a significant decrease in BNP values as well as a reduction in volumes of cardiac chambers.

Cited by 6 publications

References 16 publications

The intracardiac concentrations of the N-terminal-pro B-type natriuretic peptide (NT-proBNP) and the determinants of its secretion in patients with atrial fibrillation

The intracardiac concentrations of the N-terminal-pro B-type natriuretic peptide (NT-proBNP) and the determinants of its secretion in patients with atrial fibrillation

Is 10-second electrocardiogram recording enough for accurately estimating heart rate in atrial fibrillation

How to estimate heart rate from pulse rate reported by oscillometric method in atrial fibrillation: The value of pulse rate variation

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