The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors

Schelling, Gustav; Briegel, Josef; Roozendaal, Benno; Scheffold, Christian; Rothenhäusler, Hans-Bernd; Kapfhammer, Hans-Peter

doi:10.1016/s0006-3223(01)01270-7

Cited by 308 publications

(195 citation statements)

References 36 publications

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“…Á Acute intravenous administration of hydrocortisone was superior to placebo in preventing emergence of post-traumatic symptoms, both in intensive care patients with septic shock and in patients undergoing cardiac surgery (Schelling et al 2001(Schelling et al , 2004…”

Section: ) (E)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

696

400

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In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, recommendations for the pharmacological treatment of anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are presented. Since the publication of the first version of this guideline, a substantial number of new randomized controlled studies of anxiolytics have been published. In particular, more relapse prevention studies are now available that show sustained efficacy of anxiolytic drugs. The recommendations, developed by the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders, a consensus panel of 30 international experts, are now based on 510 published randomized, placebo-or comparator-controlled clinical studies (RCTs) and 130 open studies and case reports. First-line treatments for these disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and the calcium channel modulator pregabalin. Tricyclic antidepressants (TCAs) are equally effective for some disorders, but many are less well tolerated than the SSRIs/ SNRIs. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of substance abuse disorders. Potential treatment options for patients unresponsive to standard treatments are described in this overview. Although these guidelines focus on medications, non-pharmacological were also considered. Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines.

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Section: ) (E)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

696

400

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“…Such an effect might be relevant to understanding why systemic cortisol administration has recently been shown to be useful in preventing as well as alleviating symptoms of PTSD (Schelling et al, 2001;Aerni et al, 2004). Third, because the effects of SER in MNL from subjects with PTSD are directionally different than what would be expected in MDD, the findings suggest a broader view of the effects of antidepressants on the HPA axis that may account for the efficacy of these medications in a wide range of conditions, only some of which are associated with hypercortisolism and/or reduced negative feedback inhibition.…”

Section: Effect Of Sertraline On Glucocorticoid Sensitivity R Yehuda mentioning

confidence: 99%

Effect of Sertraline on Glucocorticoid Sensitivity of Mononuclear Leukocytes in Post-Traumatic Stress Disorder

Yehuda

Yang

Golier

et al. 2005

Neuropsychopharmacol

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This study examined the effects of sertraline (SER) on glucocorticoid sensitivity in mononuclear leukocytes (MNL) from eight subjects with current post-traumatic stress disorder (PTSD) and nine comparison subjects. In all, 60 ml of blood was withdrawn by venipuncture at 0800, and MNL were isolated from blood and divided into two portions: the first contained live cells incubated with a series of concentrations of dexamethasone (DEX); the second contained cells incubated with similar concentrations of DEX þ 2 mM SER. Group difference in the concentrations of DEX required to inhibit lysozyme activity by 50% were evaluated under conditions of DEX-only and DEX þ SER using analysis of covariance (ANCOVA). A significant Group Â Condition interaction reflected that SER altered the lysozyme IC 50-DEX in the direction of decreasing sensitivity to glucocorticoids in PTSD while having no uniform effect in cells from comparison subjects. The data provide support for the idea that glucocorticoid receptors might be more responsive to antidepressants in PTSD than in persons without PTSD. Insofar as increased sensitivity to glucocorticoids has been linked with PTSD, the actions of SER on the lysozyme IC 50-DEX suggest that this medication may target a biologic alteration associated with PTSD pathophysiology.

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“…Za nastanak sindroma rizik povećavaju postojeća anksioznost i depresija, kao i ženski spol, starosna dob <50 godina, niži stupanj obrazovanja, već postojeća invalidnost/nezaposlenost, uživanje alkohola, primjena sedativa i analgezije [13]. Rezultati recentnih studija upućuju da su glukokortikoidi povezani sa smanjenim rizikom nastanka PTSP-a [14,15]. Smatra se da je smanjena razina kortizola povezana s razvojem PTSP-a.…”

Section: Psihički čImbeniciunclassified

Sindrom postintenzivne skrbi Post-intensive care syndrome

Kovačević

Kalauz

Krikšić

et al. 2017

SG/NJ

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SažetakPozadina: Sindrom postintenzivne skrbi (engl. PICS-post-intenzive care syndrome) definira se kao pogoršanje kognitivnih, psihičkih i fizičkih funkcija kod bolesnika koji su preboljeli bolesti s visokim stupnjem smrtnog ishoda u jedinici intenzivnog liječenja (JIL). Precizna prevalencija sindroma je nepoznata: prema publiciranim rezultatima procjenjuje se da se kod jedne četvrtine do jedne polovine preživjelih verificira postojanje nekih od navedenih smetnji. Cilj: Cilj je preglednog članka iznaći zaključke provedenog empirijskog istraži-vanja koje istražuje učestalost kognitivnih, psihičkih i fizičkih simptoma u bolesnika nakon otpuštanja iz jedinice intenzivnog liječenja. Istraživanje je trostupanjsko te se ispituju pokazatelji sindroma PICS-a, koji su čimbenici rizika povezani s povećanom incidencijom nastanka sindroma postintenzivne skrbi, i ispitati koje metode i terapijski postupci smanjuju rizik u nastanku PICS-a. Rezultati: Simptomi su sindroma postintenzivne skrbi slabost mišića, slabija pokretljivost, lošija koncentracija, slabljenje memorije, umor, anksioznost i depresivno raspoloženje. Čimbenici rizika nastanka sindroma postintenzivne skrbi neuromuskularni su poremećaji, demencija, psihijatrijske bolesti, JIL-specifični čimbenici, uporaba mehaničke ventilacije, delirij, sepsa i sindrom akutnog respiratornog distresa. Učestalost nastanka PICS-a može se smanjiti uporabom metoda/postupaka koji smanjuju vremensko trajanje sedacije i ubrzavaju ranu fizičku rehabilitaciju. Zaključak: Sindrom se verificira kad se pronađu novi ili utvrdi postojanje pogoršanja znakova i simptoma jednog ili više od triju organskih sustava: kognitivni, psihički i fizički. Identifikacija svake navedene komponente potvrđuje se testiranjima. Znakovi i simptomi sindroma postintenzivne skrbi mogu se poboljšati tijekom prvih 6 do 12 mjeseci nakon otpuštanja iz jedinice intenzivnog liječenja. Međutim, kod mnogih pacijenata, deficiti perzistiraju godinama. PICS je povezan s nemogućnošću povratka na posao i smanjenom kvalitetom stupnja života, kao i povećanim rizikom od smrti tijekom nekoliko sljedećih godina. AbstractBackground: Post-intensive care syndrome (PICS) is defined as worsening of cognitive, psychological and physiological functions in patients with critical conditions, treated in the intensive care units (ICU). Despite the fact that the prevalence of the PICS is yet unknown, it is estimated that up to ¼ to one half of the above-mentioned patients is suffering from some of the issues associated with PICS. Previous neuromuscular disorders, dementia, psychiatric illnesses as well as ICU-specific factors, especially mechanical ventilation, delirium, sepsis and acute respiratory distress syndrome are known as risk factors for occurrence of PICS. Aim/Purpose: The aim of this systematic review is to extract conclusions from empirical data regarding different cognitive, psychological and physiological functions that the patients released from the intensive care units (ICU) are facing. The objective of this review was to deter...

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The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors

Cited by 308 publications

References 36 publications

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Effect of Sertraline on Glucocorticoid Sensitivity of Mononuclear Leukocytes in Post-Traumatic Stress Disorder

Sindrom postintenzivne skrbi Post-intensive care syndrome

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