The effect of storage at ambient humidity on the BET-specific surface area of tablets compacted from different materials

Effect of Moisture and Pressure on Tablet Compaction Studied With FTIR Spectroscopic Imaging

“…The effect of water vapor to the stability of the drug could alter the tablet performance by changing the molecular state or potential polymorphic transitions of the drug 5,12,13. A previous study reported the effect of storage at ambient humidity on the BET‐specific surface area of tablets compacted from different components, with different water solubility 14. An irreversible decrease in surface area was observed after being exposed to the ambient humidity which was caused by moisture condensation and blocking of pores in the tablet 14.…”

“…A previous study reported the effect of storage at ambient humidity on the BET‐specific surface area of tablets compacted from different components, with different water solubility 14. An irreversible decrease in surface area was observed after being exposed to the ambient humidity which was caused by moisture condensation and blocking of pores in the tablet 14. Hydroxypropylmethylcellulose (HPMC) 2,3,15 is one of the most commonly used excipient for controlled release pharmaceutical tablets.…”