Effect of Moisture and Pressure on Tablet Compaction Studied With FTIR Spectroscopic Imaging

Elkhider, Noha; Chan, K. L. Andrew; Kazarian, Sergei G.

doi:10.1002/jps.20805

Cited by 36 publications

(14 citation statements)

References 22 publications

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“…By taking several images of a sample, changes in the distribution can be studied; for example, when undergoing compaction, the positions of particles within the tablet rearrange, followed by the particles crumbling, and then the voids within the material collapse resulting in a harder denser material. This process can be studied in situ using ATR-FTIR imaging [69,70].…”

Section: Imaging Of Compacted Pharmaceutical Tabletsmentioning

confidence: 99%

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Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Kazarian

Wray

2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

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Section: Imaging Of Compacted Pharmaceutical Tabletsmentioning

confidence: 99%

“…The controlled humidity approach has been applied to study the compaction of pharmaceutical formulations in ATR mode [70]. Tablets consisting of ibuprofen and HPMC were exposed to humidities between 0% and 80% before being compacted into tablets.…”

Section: Imaging Of Water Sorption In Pharmaceutical Formulations Andmentioning

confidence: 99%

Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Kazarian

Wray

2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

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“…Recently, infrared (IR), near-infrared (NIR), Raman and terahertz pulsed imaging technology have been utilized as a process analytical technology (PAT) in various kinds of analysis of pharmaceutical products, such as the ingredient distribution and polymorph ratio within tablets and coating thickness [2][3][4][5][6][7]. These techniques based on vibration spectroscopy make it possible to reveal physical or chemical mechanism at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

Self-modeling curve resolution (SMCR) analysis of near-infrared (NIR) imaging data of pharmaceutical tablets

Awa

Okumura

Shinzawa

et al. 2008

Analytica Chimica Acta

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“…ATR FT-IR imaging has, therefore, become a very useful tool for studying the distribution of different components in compacted tablets [51,73,[77][78][79][80][81]. These advantages are important for this sample type because it is difficult to microtome a tablet into a thickness that would be suitable for transmission studies (usually <10 μm), and the alternative diffuse-reflection technique is often difficult to calibrate for quantitative analysis.…”

Section: Imaging Of Compacted Tabletsmentioning

confidence: 99%

FT‐IR Imaging in ATR and Transmission Modes: Practical Considerations and Emerging Applications

Dougan

Chan

Kazarian

2014

Infrared and Raman Spectroscopic Imaging

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Fourier transform infrared (FT-IR) spectroscopic imaging is a powerful chemical imaging technique. A range of approaches and applications of FT-IR imaging have been developed in both attenuated total reflection (ATR) and transmission modes for a broad range of materials and chemical systems. ATR and transmission approaches are often complementary -providing different advantages depending on the requirements of the system under study with respect to chemical composition, field of view (FOV), or spatial resolution, for instance.FT-IR spectroscopic imaging is achieved by coupling an FT-IR spectrometer with a focal plane array (FPA) detector. Unlike single-element detectors, which provide an average signal from the illuminated sample area, FPA detectors allow the simultaneous detection of spatially resolved spectra across the whole imaged area as shown schematically in Figure 9.1. This powerful approach of coupling FT-IR spectroscopy with FPA detectors and thereby obtaining simultaneous, spatially resolved spectra allows systems to be studied as a function of spectral, spatial, and temporal domains. Since a full spectrum is recorded at each pixel, different chemical species and their relationship with one another can be revealed by studying the resulting images. Generally, the images are prepared by plotting the distribution of the integrated absorbance of a vibrational band of interest and assigning a false color to indicate its relative absorbance. Many images showing the distribution of different components in the sample can be generated from a single imaging measurement simply by post-measurement data analysis. Other parameters such as band position or width can be used to reveal chemical information about the system.Single-element detectors or linear array detectors are capable of building chemical images through point-by-point mapping or raster scanning, respectively. Although this may be sufficient for some applications, the increased time required and the consecutive collection of spectra to build an image may not permit the study of dynamic systems nor is it particularly suitable for high-throughput studies.

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Effect of Moisture and Pressure on Tablet Compaction Studied With FTIR Spectroscopic Imaging

Cited by 36 publications

References 22 publications

Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Self-modeling curve resolution (SMCR) analysis of near-infrared (NIR) imaging data of pharmaceutical tablets

FT‐IR Imaging in ATR and Transmission Modes: Practical Considerations and Emerging Applications

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