The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat

Reed, J. D.; Sanders, David J.; Thorpe, Valerie

doi:10.1113/jphysiol.1971.sp009415

Cited by 42 publications

(30 citation statements)

References 14 publications

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“…suggested that splanchnic stimulation at <4 Hz acted via parasympathetic ganglia but at > 8.Hz it also appeared to have a direct effect on muscle. Reed, Sanders & Thorpe (1971) found that splanchnic stimulation reduced the response to vagal stimulation and to intra-arterial acetylcholine. Furness & Costa (1974) have argued that direct effects of sympathetic neurones on intestinal muscle occur only in vitro or at unrealistically high (> 10 Hz) frequencies of electrical stimulation.…”

Section: Introductionmentioning

confidence: 99%

Interactions between splanchnic and vagus nerves in the control of mean intragastric pressure in the ferret.

Andrews¹,

Lawes²

1984

The Journal of Physiology

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SUMMARY1. To determine whether splanchnic nerves relax the stomach by direct or indirect mechanisms, ramp inflations of the stomach, section and electrical stimulation of the vagus and greater splanchnic nerves, and step inflations of the duodenum were used.2. A high threshold, sustained inhibition of the gastric pressure response to ramp inflation was mediated by the vagus. Prior splanchnectomy increased vagal inhibition.3. The greater splanchnic nerves had no effect on gastric responses to inflation, although after vagotomy they were shown to be mediators of a low threshold, powerful but transient inhibition of the stomach. This was not dependent on intrinsic neurones with nicotinic receptors.4. Electrical stimulation of the greater splanchnic nerves produced a relaxation of the stomach, the magnitude of which was determined by resting pressure. Splanchnically mediated relaxation was not abolished by atropine, nor was it reduced by concurrent vagal stimulation. At submaximal levels of vagal stimulation the two nerves had a partially additive effective on relaxation.5. Duodenal inflation had an effect on intracorpus pressure similar to that of electrical stimulation of the greater splanchnic nerves on intragastric pressure. Reflex relaxation of the corpus evoked by duodenal distension was decreased by atropine but greatly increased by atropine coupled with vagotomy. These changes were caused by variations in resting pressure.6. It was concluded that the principal effect of splanchnic nerves on mean gastric pressure is direct and does not depend on inhibition of cholinergic neurones either centrally or peripherally. Evidence is presented for central interactions between the vagus and the greater splanchnic nerves in the anaesthetized ferret.

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Section: Introductionmentioning

confidence: 99%

Interactions between splanchnic and vagus nerves in the control of mean intragastric pressure in the ferret.

Andrews¹,

Lawes²

1984

The Journal of Physiology

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“…We have previously reported (Reed, Smy, Venables & Harris, 1973) that burimamide injected in the unstimulated anaesthetized cat does not produce gastric acid secretion. However, these results were obtained in the later parts of experiments in which secretion had previously been stimulated by histamine, gastrin or pentagastrin infusion.…”

Section: Discussionmentioning

confidence: 96%

The Effects of Burimamide and Metiamide on Basal Gastric Function in the Cat

Smy

Reed

et al. 1975

British J Pharmacology

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Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. Metiamide, in doses which inhibited pentagastrin‐stimulated acid secretion, produced no increase in gastric acid secretion in conscious animals, or gastric acid secretion or gastric mucosal blood flow in the anaesthetized cat. Metiamide did not influence the amount of acid which diffused out of the stomach when instilled at pH values between 1.5 and 6.0. The possible mode of action of burimamide in increasing basal gastric secretion is discussed.

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“…Furthermore, local intraarterial infusion of either hydrogen peroxide, which can form hydroxyl radicals, or a superoxide generating system, induced macroscopically apparent damage in the mucosa, that was attenuated by concurrent administration of catalase or superoxide dismutase, respectively (Esplugues & Whittle, 1989a (Thompson & Vane, 1953;Reed et al, 1971). Other early studies in the dog demonstrated a reduction in gastric blood flow following parenteral administration of adrenaline or noradrenaline, as determined both by a clearance technique and by electromagnetic flowprobes (Cowley & Code, 1970;Zinner et al, 1975).…”

Section: Microvascular Ischaemia and Injurymentioning

confidence: 99%

Untitled

1993

British J Pharmacology

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The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat

Cited by 42 publications

References 14 publications

Interactions between splanchnic and vagus nerves in the control of mean intragastric pressure in the ferret.

Interactions between splanchnic and vagus nerves in the control of mean intragastric pressure in the ferret.

The Effects of Burimamide and Metiamide on Basal Gastric Function in the Cat

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