The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis

Taneli, Fatma; Vatansever, Seda; Ulman, Cevval; Yılmaz, Ömer; Giray, Gülşen; Genç, Abdülkadir; Taneli, Can

doi:10.1016/j.acthis.2004.11.001

Cited by 39 publications

(33 citation statements)

References 24 publications

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“…Prolonged testicular torsion leads to testicular ischaemia and high levels of oxidative stress with ROS production (Taneli et al 2005). ROS-induced oxidative stress was increased in testicular tissue following detorsion, indicates the reperfusion injury (Guimaraes et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Lycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Rats

Hekimoğlu

Kurçer

Aral

et al. 2009

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Lycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Rats

Hekimoğlu

Kurçer

Aral

et al. 2009

Tohoku J. Exp. Med.

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“…Prolonged torsion leads to testicular ischaemia and high levels of oxidative stress in the ipsilateral testes associated with NO and H 2 O 2 production, increased lipid peroxide formation, isoprostane accumulation, antioxidant enzyme depletion and increased rates of mitochondria-mediated apoptosis in the germ line. [51][52][53] Even short periods of ischaemia, for 3 hours or less, can lead to a high levels of oxidative stress in the testes, depletion of testicular glutathione levels and the consequent disruption of spermatogenesis. Significantly, the level of peroxidative damage observed in testicular tissue increases following detorsion, indicating the induction of reperfusion injury.…”

Section: Disruption Of the Antioxidant Status Of The Testesmentioning

confidence: 99%

Antioxidant Systems and Oxidative Stress in the Testes

Aitken

Roman

2009

Advances in Experimental Medicine and Biology

159

105

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“…In our previous experimental study, SFSM is shown to promote testicular NO and germ cell apoptosis in the ipsilateral testis [7] . A marked elevation in the NO level is found 24 h after SFSM, especially in the ipsilateral testis [7] .…”

Section: Discussionmentioning

confidence: 99%

“…This loss of spermatogenesis after injury of testis is due to germ cell apoptosis [4][5][6] . In our previous experimental study, spermatic vessel ligation which produces low-grade ischemia is shown to promote testicular nitric oxide (NO) and germ cell-specifi c apoptosis in the ipsilateral rat testis [7] . Thus, testicular isch-G -nitro-L -arginine methyl ester ( L -NAME), a nitric oxide (NO) synthase (NOS) inhibitor, in preventing testicular ischemic damage and germ cell-specifi c apoptosis in rats.…”

Section: Introductionmentioning

confidence: 99%

Pre-Ischemic Administration of Nitric Oxide Synthase Inhibitors Reduced Germ Cell Apoptosis after Spermatic Vessel Ligation in the Rat Testis

Taneli¹,

Vatansever²,

Ulman³

et al. 2005

Urol Int

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Introduction: The Fowler-Stephens maneuver,a modeofspermatic vessel ligation, is a method of choice in the management of high testes. The aim of the present study is to investigate the effects of pre-ischemic administration of N^G-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase (NOS) inhibitor, in preventing testicular ischemic damage and germ cell-specific apoptosis in rats. Materials and Methods: 30 min before ligation of the spermatic vessels, L-NAME was administered intraperitoneally to a group of rats and saline was given to another group of rats (controls). Biochemical assessments of NO and germ cell-specific apoptosis were performed. Results: Testicular NO levels in the L-NAME group showed significant decreases in the ipsilateral (p = 0.004) and contralateral (p = 0.015) testes in relation to those of the control group. The apoptotic indices were found in 2.3% of the L-NAME group and 3.1% of the control group. Conclusion: Pre-ischemic administrations of the NOS inhibitor, L-NAME, effectively decreased NO production and to some degree caused a reduction in germ cell apoptosis in the rat testes after spermatic vessel ligation. Further studies are mandatory to confirm our preliminary results and to address the potential introduction of NOS inhibitors into clinical practice.

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The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis

Cited by 39 publications

References 24 publications

Lycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Rats

Lycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Rats

Antioxidant Systems and Oxidative Stress in the Testes

Pre-Ischemic Administration of Nitric Oxide Synthase Inhibitors Reduced Germ Cell Apoptosis after Spermatic Vessel Ligation in the Rat Testis

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