The Effect of Soy Nuts on Glycemic Control, Lipid Profile and Insulin-Resistance in Type 2 Diabetic Patients

Abstract

Background: Type 2 diabetes has a high prevalence and a growing trend. The use of a proper diet treatment is one of the therapeutic approaches of patients. The use of the soy has shown the effective results in glycemic control of patients with type 2 diabetes; however, data are paradoxical. The present study aimed to examine the effectiveness of soy nuts on glycemic control, blood pressure and lipid profile and insulin-resistance of the diabetic patients. Methods: In this case-control study 69 type 2 diabetic patients were randomly divided into two groups: intervention (n = 35) and control (n = 34). The patients in the intervention group substituted 60 grams of soy nuts as a part of the daily protein requirement for eight weeks. In contrast, the patients in the control group received usual diet of diabetes (no soy). The drugs received by patients had not been changed during the intervention period. Before and at the end of the intervention, Hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum insulin levels, insulin-resistance, systolic and diastolic blood pressure, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and total cholesterol, and triglycerides (TG) were measured in the patients. Insulin-resistance was calculated by Homeostatic model assessment-IR formula (HOMA-IR). Results: Soy consumption significantly lowered FPG (P = 0.03), HbA1c (P < 0.01), plasma insulin levels (P = 0.01), insulin-resistance (P = 0.01), total cholesterol (P < 0.01) and LDL-c (P = 0.01), but did not have any significant effect on systolic blood pressure (P = 0.4), diastolic blood pressure (P = 0.2), HDL-c (P = 0.4) and TG (P = 0.2). Conclusion: Consumption of soy nuts in type 2 diabetic patients * Corresponding author. A. Sedaghat et al. 2 can cause an improvement in the glycemic control and insulin-resistance, and the lipid profile does not have any significant effect on blood pressure.

The effect of processed Tempeh Gembus to triglycerides levels and insulin resistance status in women with obesity

“…Fiber content (Lu et al, 2013) and high protein (Ahmed et al, 2010) in Okara has the ability to reduce the FBG level. These fibers contain bioactive components with high viscosity, these components can directly slow the discharge of the stomach and absorption of glucose due to the hypoglycemic effect on Okara (Sedaghat et al, 2015). The mechanism of fiber to decrease in blood glucose levels is strongly influenced by the absorption of carbohydrates in the intestines.…”

Peran Fisiologis Sari Kedelai Hitam Diperkaya Mikroenkapsulan Minyak Sawit Mentah Pada Penderita Diabetes Melitus Tipe-2

“…Berdasarkan hasil penelitian yang dilaporkan oleh Sedaghat et al (2015), relawan DM-2 yang diberi intervensi kedelai sebanyak 30 g pada pagi dan sore selama 8 minggu menunjukkan penurunan GDP secara signifikan dari 165,50±51,00 mg/dL menjadi 148,20±49,00 mg/dL. Hasil GDP ini berbeda dengan hasil penelitian dimana nilai GDP relawan yang intervensi produk tidak menunjukkan penurunan signifikan dari 185,82±95,50 menjadi 143,09±58,93 mg/dL.…”

“…Hal ini terjadi diduga relawan yang diintervensi dengan produk tidak dikontrol pola diet selama masa intervensinya. Pada relawan kontrol, Sedaghat et al (2015), melaporkan terjadi peningkatan kadar GDP secara signifikan dari 161,70±41,20 mg/dL menjadi 167,50±42,30 mg/dL pada grup kontrol. Temuan ini juga berbeda dari temuan pada grup kontrol pada penelitian ini yang secara kontras tidak berbeda signifikan (dari 255,00±93,33 mg/dL menjadi 220,00±55,50 mg/dL).…”

Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction

“…The consumption of nuts has gained attention once it was demonstrated an inverse association of nut consumption with total and cause-specific mortality in healthy adults (mean age of 60 years) [77]. Also regarding nuts consumption, it has been recently demonstrated that the consumption of 60 grams per day of soy nuts in patients with T2DM for eight weeks was able to reduce fasting blood glucose, insulin concentration, as well as systolic and diastolic blood pressure [78].…”