The effect of soy isoflavone combined with calcium on bone mineral density in perimenopausal Chinese women: a 6-month randomised double-blind placebo-controlled study

Zhang, Xinsheng; Liu, Yinghua; Xu, Qing; Zhang, Yong; Liu, Lu; Li, Huizi; Li, Feng; Liu, Zhao; Yang, Xia; Yu, Xiaoming; Kong, Aijing

doi:10.1080/09637486.2019.1673703

Cited by 17 publications

(23 citation statements)

References 31 publications

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“…Of these, 21 papers contained duplicate publications, only bone mineral density was reported, the required data were missing, or they did not meet all the inclusion criteria. Therefore, a total of twenty-three studies were included in our final analysis [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kanadys

Barańska

Błaszczuk

et al. 2021

IJERPH

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This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their quality was evaluated according to Cochrane criteria. The levels of markers were evaluated in a total of 1114 women who ingested mean daily doses of 98.2 mg (30.9 to 300) of soy isoflavones for 3 to 24 months, in comparison to those of 1081 subjects who used a placebo. Ten, eighteen, eight, and fourteen comparison studies were finally selected for an estimation of the effects on osteocalcin (OC), bone alkaline phosphatase (BAP), pyridinoline (PYD), and deoxypyridinoline (DPD), respectively. A summary of the results of intervention was as follows: 4.16%, 95% CI: –7.72–16.04, p = 0.49 for OC; 5.50%, 95% CI: –3.81–14.82, p = 0.25 for BAP; –12.09%, 95% CI: –25.37–1.20, p = 0.07 for PYD; and –7.48%, 95% CI: –15.37–0.41, p = 0.06 for DPD. The meta-analysis of the included studies revealed some statistically insignificant observations that soy isoflavones intake is associated with a trend in increased levels of OC and BAP, as well as a trend in reduced levels of PYD and DPD. Soy isoflavones may have a beneficial effect on bone formation markers, but this requires extensive multi-center research.

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Section: Resultsmentioning

confidence: 99%

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kanadys

Barańska

Błaszczuk

et al. 2021

IJERPH

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“…Baseline characteristics of patients in the soy isoflavone group and the placebo group (Siefker & DiSilvestro, 2006) and MDA (Pusparini et al, 2013;Zhang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…In agreement with this finding, some previous studies indicated that soy isoflavone consumption caused no change in oxidative stress markers such as Ox‐LDL (Imani et al, 2009; Reverri, LaSalle, Franke, & Steinberg, 2015), 8‐iso‐prostaglandin F 2α (Siefker & DiSilvestro, 2006), lipid proxides (Cupisti et al, 2007; Giolo et al 2018), superoxide dismutase, and total antioxidant capacity (Giolo et al 2018). However, some investigations have shown that isoflavones decrease serum Ox‐LDL (Siefker & DiSilvestro, 2006) and MDA (Pusparini et al, 2013; Zhang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies in nonuremic subjects have shown that isoflavones or soy protein can decrease oxidative stress (Pusparini, Dharma, Suyatna, Mansyur, & Hidajat, 2013; Zhang et al, 2019), and serum C‐reactive protein (CRP) as a systemic inflammation marker (Azadbakht, Atabak, & Esmaillzadeh, 2008; Sathyapalan et al, 2011). In addition, few studies in hemodialysis patient showed that soy protein reduced plasma oxidized low‐density lipoprotein (Ox‐LDL) concentration as an oxidative stress marker (Siefker & DiSilvestro, 2006), and there was an inverse association between serum CRP and total isoflavone concentration (Fanti, Asmis, Stephenson, Sawaya, & Franke, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Effects of soy isoflavones on serum systemic and vascular inflammation markers and oxidative stress in peritoneal dialysis patients: A randomized controlled trial

Yari

Tabibi²,

Najafi

et al. 2020

Phytotherapy Research

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Cardiovascular disease (CVD) is common in peritoneal dialysis (PD) patients. This study was designed to investigate the effects of isoflavones on systemic and vascular inflammation markers and oxidative stress in PD patients. In this randomized clinical trial, 40 PD patients were randomly assigned to either the isoflavone or the placebo group. The isoflavone group received 100 mg soy isoflavones daily for 8 weeks, whereas the placebo group received corresponding placebos. At baseline and the end of eighth week, serum high sensitive C-reactive protein (hs-CRP), intercellular adhesion molecule type 1 (ICAM-1), vascular cell adhesion molecule type 1 (VCAM-1), E-selectin, and malondialdehyde were measured. Serum VCAM-1 decreased significantly in the isoflavone group at the end of Week 8 compared to baseline (p = .01), whereas no significant change was observed in the placebo group. Serum ICAM-1 decreased significantly in the isoflavone (p = .01) and placebo (p = .01) group compared to baseline. However, the reduction of ICAM-1 was significantly higher in the isoflavone group than in the placebo group (p = .02). There were no significant differences between the two groups in mean changes of serum E-selectin, malondialdehyde, and hs-CRP. This study indicates that isoflavones reduce serum VCAM-1 and ICAM-1, which are two CVD risk factors, in PD patients.

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“…Additionally, one of the main foods in this healthy dietary pattern were legumes, which contain the phytoestrogen isoflavone. Metaanalysis and randomized controlled trials demonstrated soy isoflavones have potential bone-specific effects in women (39,40). The matrix of soy protein-enriched soy isoflavones may improve their bioavailability and biologic efficacy, improving tibia bone architecture (41).…”

Section: Discussionmentioning

confidence: 99%

Association Between Dietary Patterns and Fluorosis in Guizhou, China

et al. 2020

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Objective: Many studies have explored the effects of individual foods or nutrients on fluorosis, but no studies have focused on dietary patterns. This study examined the relationship between dietary patterns and coal-burning fluorosis in Guizhou, China. Methods: This 1:1 matched case-control study was conducted in Zhijin County of Guizhou province with a sample size of 200 cases of fluorosis and 200 age and gender matched controls. Habitual dietary intake was assessed by face-to-face interviews, using a validated 75-item food frequency questionnaire (FFQ) and various covariates using structured questionnaires. The dietary patterns were identified by factor analysis. Results: The factor analysis identified three major dietary patterns which were labeled healthy, easy-to-roast and high protein. After adjusting for various confounding factors, a decreased risk for fluorosis was observed in the highest tertile of the healthy dietary pattern relative to the lowest tertile (OR = 0.47, 95% CI = 0.27-0.84, P-trend = 0.003) and a positive association was observed between the easy-to-roast dietary pattern and fluorosis risk (OR = 2.05, 95% CI = 1.15-3.66), with a significant linear trend (P = 0.017). We did not find an association between fluorosis risk and the high protein dietary pattern. The relationships remained significant when the analyses were stratified by gender and fluorosis subtypes. Conclusion: The healthy dietary pattern may lower coal-burning fluorosis risk; in contrast, the easy-to-roast dietary pattern significantly increases the risk of coalburning fluorosis.

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The effect of soy isoflavone combined with calcium on bone mineral density in perimenopausal Chinese women: a 6-month randomised double-blind placebo-controlled study

Cited by 17 publications

References 31 publications

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of soy isoflavones on serum systemic and vascular inflammation markers and oxidative stress in peritoneal dialysis patients: A randomized controlled trial

Association Between Dietary Patterns and Fluorosis in Guizhou, China

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