The effect of some biphenyl solubilizing and suspending agents on biphenyl 4-hydroxylase of rabbit liver microsomes

Hook, Gary E. R.; Bend, John R.; Fouts, James R.

doi:10.1016/0009-2797(73)90024-0

Cited by 14 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HOOK et al (1973) have reported that at 1.44 mol/l of ethanol the cytochrome P-450 content of liver microsomes did not decrease significantly. The activity of cytochrome P-450 reductase is, on the other hand, inhibited significantly already at 0.5 mol/l of ethanol (HOOK et al 1973). The non-specificinhibitionof hydroxylation reactions at molar concentrations of ethanol obviously is different from the more specific inhibition of the hydroxylation of type I1 compounds which is seen at millimolar concentrations of ethanol (COHEN & MAN-NERING 1973).…”

Section: Discussionmentioning

confidence: 98%

Ethanol Induced Alteration of Microsomal Membrane Bound Enzymes of Rat Liver in Vitro

Marniemi

Aitio

Vainio

1975

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

A bstract: Ethanol appeared to inhibit more readily the 0-demethylation of p-nitroanisole than the activity of arylhydrocarbon hydroxylase. Arylhydrocarbon hydroxylase was more sensitive to the inhibition by ethanol in control or phenobarbital pretreated rats than in rats administered 3,4-benzpyrene. Ethanol was shown to activate the glucuronidation of p-nitrophenol at 2.45 mol/l, which was followed by inhibition at higher ethanol concentrations. A similar activation could also be demonstrated in rats pretreated with phenobarbital or 3,4-benzpyrene. This activation was not seen in microsomes pretreated in vitro with detergents like digitonin and cetylpyridinium chloride. Glucose 6-phosphatase was not clearly inhibited until the ethanol concentration was as high as 4 mol/l. Digitonin and trypsin treatments of the microsomal membrane in virro appeared to activate the measurable glucose 6-phosphatase activity.

show abstract

Section: Discussionmentioning

confidence: 98%

Ethanol Induced Alteration of Microsomal Membrane Bound Enzymes of Rat Liver in Vitro

Marniemi

Aitio

Vainio

1975

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

show abstract

“…Sodium carboxymethylcellulose is commonly used as suspending agent in the pharmaceutical industry (7). Some natural polymers have found uses as suspending agents (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), as binders and sustained-release matrix in tablet formulations (19)(20)(21)(22)(23)(24), as film coating agent (25), thickeners in cosmetics, and in food (26).The research into and use of natural materials in pharmaceutical formulations, particularly in developing countries will continue to be relevant because of local accessibility, natural abundance, cost effectiveness, and eco-friendliness compared to synthetic and semi-synthetic excipients.…”

Section: Introductionmentioning

confidence: 99%

Effect of Grewia Gum as a Suspending Agent on Ibuprofen Pediatric Formulation

Ogaji

Hoag

2011

AAPS PharmSciTech

View full text Add to dashboard Cite

The purpose of this work was to evaluate the potential of grewia gum (GG) as a suspending agent in pharmaceutical oral formulation using ibuprofen as model drug. Ibuprofen pediatric suspension (25 mg/5 mL) was formulated with grewia gum (0.5% w/v) as the suspending agent. Similar suspensions of Ibuprofen containing either sodium carboxymethylcellulose (Na-CMC) or hydroxymethylpropylcellulose (HPMC) were also produced. The suspensions were evaluated for ease of redispersion, sedimentation, rheological properties, and the effect of aging on the rheological properties at 25°C. The particle size and particle size distributions of the dispersed solute were determined. The redispersion time was 19, 11, and 0.5 min, respectively, for formulation containing Na-CMC, HPMC, and GG .The sedimentation volumes were 0.05, 0.05, and 0.125 mL, respectively, for Na-CMC, HPMC, and GG . Viscosities of suspensions at spindle speed of 25 rpm were of the order: GG > HPMC > Na-CMC when freshly prepared and of the order: HPMC > GG > Na-CMC within 6 months of storage. The particles size was 72.72, 73.82, 81.93, and 83.41 μm, respectively, for suspensions containing Na-CMC, ibuprofen alone, HPMC, and GG. Greatest hysteresis was observed in formulation containing HPMC. All the formulations were stable. It was our conclusion that the difference in the physicochemical properties of ibuprofen pediatric formulations was influenced more by the suspending agent used in the formulations than the drug. GG combined better redispersion with minimal changes in viscosity on storage compared to Na-CMC and HPMC as suspending agent. Thus GG may serve as a good suspending agent requiring no further aid in suspension redispersibility.

show abstract

Hepatic and Extrahepatic Mixed‐Function Oxidases

Bend

Hook

1977

Comprehensive Physiology

View full text Add to dashboard Cite

The effect of some biphenyl solubilizing and suspending agents on biphenyl 4-hydroxylase of rabbit liver microsomes

Cited by 14 publications

References 34 publications

Ethanol Induced Alteration of Microsomal Membrane Bound Enzymes of Rat Liver in Vitro

Ethanol Induced Alteration of Microsomal Membrane Bound Enzymes of Rat Liver in Vitro

Effect of Grewia Gum as a Suspending Agent on Ibuprofen Pediatric Formulation

Hepatic and Extrahepatic Mixed‐Function Oxidases

Contact Info

Product

Resources

About